FB2020_06, released Dec 22, 2020

Aberration: Dmel\Df(2L)TW50

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General Information
Symbol
Df(2L)TW50
Species
D. melanogaster
Name
Deficiency (2L) Ted Wright
FlyBase ID
FBab0001655
Feature type
chromosomal_deletion
Also Known As
Df(2L)50
Computed Breakpoints include

36E4-36F1;38A6-38A7

Features within 36E4--38A7
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Stathakis et al., 1995)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Boube et al., 1997, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Pentz et al., 1990, Wright et al., 1976)
Breakpoints

36E4-36F1;38A6-38A7

(Boube et al., 1997, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Pentz et al., 1990, Wright et al., 1976)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

kel << bk1 << fs(2)eo3 << Fs(2)Ket << bk2 << barr

Genetic mapping information
Comments

Distal DNA breakpoints given (Steward, McNally, and Schedl, 1984, Nature 311: 262-65)

Comments on Cytology

All limits from polytene analysis (FBrf0028752)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
amd
(Wright et al., 1982, Wright et al., 1976, Wright et al., 1976)
amos
(Wright et al., 1976)
AsnRS
(Wright et al., 1976)
brat
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Schupbach and Wieschaus, 1991, Wright et al., 1976)
Catsup
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976)
Ddc
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976, Wright et al., 1976)
esc
(Wright et al., 1976)
fs(2)38ABa
(Butler et al., 2001)
Fs(2)Ket
(Schupbach and Wieschaus, 1991)
fs(2)lto3
(Schupbach and Wieschaus, 1991)
fs(2)ltoPP43
(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Schupbach and Wieschaus, 1991)
fs(2)ltoRV64
(Schupbach and Wieschaus, 1991)
hook
(Wright et al., 1976)
huc2L-20
(Silva et al., 2006)
l(2)37Ad
(Doerig, 1999.8.9, Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)37Bb
(Wright et al., 1976)
l(2)37Cb
(Wright et al., 1976)
l(2)37CDa
(Wright et al., 1976)
l(2)37CDb
(Wright et al., 1976)
l(2)37CDc
(Wright et al., 1976)
l(2)37CDd
(Wright et al., 1976)
l(2)37CDe
(Wright et al., 1976)
l(2)37CDf
(Wright et al., 1976)
l(2)37Db
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976)
l(2)37Dc
(Wright et al., 1976)
l(2)37De
(Wright et al., 1976)
l(2)37Di
(Wright et al., 1976)
l(2)37Dk
(Wright et al., 1976)
l(2)37Dl
(Wright et al., 1976)
l(2)37Dm
(Wright et al., 1976)
l(2)37Ea
(Butler et al., 2001)
l(2)37Fe
(Butler et al., 2001)
l(2)38ABa
(Butler et al., 2001)
l(2)k13805
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k14614
(BDGP Project Members, 1994-1999)
Lar
(Maurel-Zaffran et al., 2001)
ms(2)38ABa
(Butler et al., 2001)
msl-1
(Bevan et al., 1993)
pre
(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
RpL30
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
RpS26
(Wright et al., 1976)
scw
(Butler et al., 2001, Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)
spi
(Faucheux et al., 2001, Spradling et al., 1999, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Tio et al., 1994)
swm
(Wright et al., 1976)
γTub37C
(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
Partially deleted / disrupted
Molecular Data
Completely deleted
CG10211
(Marygold, 2005.1.19)
Pde11
(Marygold, 2005.1.19)
Ugt301D1
(Marygold, 2005.1.19)
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
barr
(Butler et al., 2001, Bhat et al., 1996, BDGP Project Members, 1994-1999)
Bl
(Butler et al., 2001, Wright et al., 1976)
bun
(BDGP Project Members, 1994-1999)
CadN
(Brumby et al., 2004)
crc
(Wright et al., 1976)
crp
(BDGP Project Members, 1994-1999)
dia
(Butler et al., 2001)
esg
(BDGP Project Members, 1994-1999)
Fs(2)Ket
(Butler et al., 2001)
l(2)38Ab
(Butler et al., 2001)
l(2)38ABb
(Butler et al., 2001)
l(2)38Db
(Butler et al., 2001)
l(2)38EFd
(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)10206
(BDGP Project Members, 1994-1999)
l(2)k02501
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k03002a
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k07525
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k07713
(Butler, 2001)
l(2)k09005
(Butler, 2001, BDGP Project Members, 1994-1999)
l(2)k09314b
(BDGP Project Members, 1994-1999)
l(2)k09601
(BDGP Project Members, 1994-1999)
l(2)k09613
(BDGP Project Members, 1994-1999)
l(2)k09927
(BDGP Project Members, 1994-1999)
l(2)k10239
(Butler, 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k11537
(BDGP Project Members, 1994-1999)
l(2)k14810
(Butler, 2001)
l(2)k16703
(Butler, 2001)
lt
(Wright et al., 1976)
lwr
(Butler, 2001, BDGP Project Members, 1994-1999)
M(2)39F
(Wright et al., 1976)
mat(2)cell-G
(Butler, 2001)
mat(2)ea-H
(Butler, 2001)
ncm
(Coelho et al., 2005, Marygold, 2005.1.19)
neb
(Ohkura et al., 1997, Bhat et al., 1996, BDGP Project Members, 1994-1999)
pr
(Butler et al., 2001)
RpS26
(Marygold, 2005.1.19)
spir
(Butler et al., 2001)
squ
(Butler, 2001)
tyr1
(Pentz et al., 1990)
vls
(Butler et al., 2001, Schupbach and Wieschaus, 1986)
Molecular Data
 
Acp36DE
(Marygold, 2005.1.19)
bsf
(Marygold, 2005.1.19)
CG10283
(Marygold, 2005.1.19)
CG31749
(Marygold, 2005.1.19)
Fas3
(Marygold, 2005.1.19)
grnd
(Marygold, 2005.1.19)
kon
(Marygold, 2005.1.19)
ncm
(Marygold, 2005.1.19)
RpS26
(Marygold, 2005.1.19)
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(2L)MN-6 is semi-lethal in combination with Df(2L)TW50. Surviving females have reduced fertility (male adults are not recovered).

    (Levine et al., 2007)

    Df(2L)MN-casspr shows reduced viability in combination with Df(2L)TW50.

    (Levine et al., 2007)

    Df(2L)T317/Df(2L)TW50 animals are viable and fertile.

    (Levine et al., 2007)

    Df(2L)TW50 is semi-lethal in combination with Df(2L)cact-255rv64.

    (Levine et al., 2007)

    Inferred to overlap with: Df(2L)TW137.

    (Marygold, 2005.1.19)

    Viable and fertile in combination with Df(2L)pr2b. Viable and fertile in combination with Df(2L)pr37. Semilethal, male fertile and female subfertile in combination with Df(2L)pr11163. Semilethal and fertile in combination with Df(2L)pr-M1. Viable, male fertile and female subfertile in combination with Df(2L)pr49. Viable, male sterile and female subfertile in combination with Df(2L)pr8311. Male sterile in combination with Df(2L)pr1122. Semilethal and male and female sterile in combination with Df(2L)TW1. Semilethal in combination with Df(2L)TW161.

    (Butler et al., 2001)

    No effect on In(1)wm4h position-effect variegation.

    (Wustmann et al., 1989)
    NOT in combination with other aberrations

    Intermediate second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance 25-75%.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Shows a dose-sensitive interaction with pbhs.PB.

    (Boube et al., 1997)

    Deficient embryos show an uninterpretable mutant midgut phenotype.

    (Bilder and Scott, 1995)

    Mutation does not affect the level of w expression in ph-plac+3 flies.

    (Fauvarque et al., 1995)

    Homozygous embryos are very abnormal compared to wild-type. The Malpighian tubule primordium forms but individual tubules do not bud out.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Severe morphological defect.

    (Smith et al., 1993)

    Associated with a dominant very weak Minute phenotype.

    (Wright et al., 1976)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2L)TW50 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (6)
    References (70)