FlyBase Aberration Report: Dmel\Df(2L)TW50

General Information

Symbol

Df(2L)TW50

Species

D. melanogaster

Name

Deficiency (2L) Ted Wright

FlyBase ID

FBab0001655

Feature type

chromosomal_deletion

Also Known As

Df(2L)50

Computed Breakpoints include

36E4-36F1;38A6-38A7

Features within 36E4--38A7

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

(Stathakis et al., 1995)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Boube et al., 1997, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Pentz et al., 1990, Wright et al., 1976)

Breakpoints

36E4-36F1;38A6-38A7

(Boube et al., 1997, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Pentz et al., 1990, Wright et al., 1976)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

kel << bk1 << fs(2)eo3 << Fs(2)Ket << bk2 << barr

Genetic mapping information

Comments

Distal DNA breakpoints given (Steward, McNally, and Schedl, 1984, Nature 311: 262-65)

Comments on Cytology

All limits from polytene analysis (FBrf0028752)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Wright et al., 1982, Wright et al., 1976, Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Schupbach and Wieschaus, 1991, Wright et al., 1976)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976, Wright et al., 1976)

(Wright et al., 1976)

(Butler et al., 2001)

(Schupbach and Wieschaus, 1991)

(Schupbach and Wieschaus, 1991)

(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Schupbach and Wieschaus, 1991)

(Schupbach and Wieschaus, 1991)

(Wright et al., 1976)

(Silva et al., 2006)

(Doerig, 1999.8.9, Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Wright et al., 1976)

(Butler et al., 2001)

(Butler et al., 2001)

(Butler et al., 2001)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(Maurel-Zaffran et al., 2001)

(Butler et al., 2001)

(Bevan et al., 1993)

(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Wright et al., 1976)

(Butler et al., 2001, Harbecke and Lengyel, 1995, Tearle and Nusslein-Volhard, 1987, Nusslein-Volhard et al., 1984)

(Faucheux et al., 2001, Spradling et al., 1999, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Tio et al., 1994)

(Wright et al., 1976)

(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

Partially deleted / disrupted

Molecular Data

Completely deleted

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Butler et al., 2001, Bhat et al., 1996, BDGP Project Members, 1994-1999)

(Butler et al., 2001, Wright et al., 1976)

(BDGP Project Members, 1994-1999)

(Brumby et al., 2004)

(Wright et al., 1976)

(BDGP Project Members, 1994-1999)

(Butler et al., 2001)

(BDGP Project Members, 1994-1999)

(Butler et al., 2001)

(Butler et al., 2001)

(Butler et al., 2001)

(Butler et al., 2001)

(Butler et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(Butler, 2001, BDGP Project Members, 1994-1999)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Butler, 2001, BDGP Project Members, 1994-1999)

(Butler, 2001)

(Butler, 2001, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(Butler, 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(Butler, 2001)

(Butler, 2001)

(Wright et al., 1976)

(Butler, 2001, BDGP Project Members, 1994-1999)

(Wright et al., 1976)

(Butler, 2001)

(Butler, 2001)

(Coelho et al., 2005, Marygold, 2005.1.19)

(Ohkura et al., 1997, Bhat et al., 1996, BDGP Project Members, 1994-1999)

(Butler et al., 2001)

(Marygold, 2005.1.19)

(Butler et al., 2001)

(Butler, 2001)

(Pentz et al., 1990)

(Butler et al., 2001, Schupbach and Wieschaus, 1986)

Molecular Data

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

(Marygold, 2005.1.19)

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

Df(2L)MN-6 is semi-lethal in combination with Df(2L)TW50. Surviving females have reduced fertility (male adults are not recovered).

(Levine et al., 2007)

Df(2L)MN-casspr shows reduced viability in combination with Df(2L)TW50.

(Levine et al., 2007)

Df(2L)T317/Df(2L)TW50 animals are viable and fertile.

(Levine et al., 2007)

Df(2L)TW50 is semi-lethal in combination with Df(2L)cact-255rv64.

(Levine et al., 2007)

Inferred to overlap with: Df(2L)TW137.

(Marygold, 2005.1.19)

Viable and fertile in combination with Df(2L)pr2b. Viable and fertile in combination with Df(2L)pr37. Semilethal, male fertile and female subfertile in combination with Df(2L)pr11163. Semilethal and fertile in combination with Df(2L)pr-M1. Viable, male fertile and female subfertile in combination with Df(2L)pr49. Viable, male sterile and female subfertile in combination with Df(2L)pr8311. Male sterile in combination with Df(2L)pr1122. Semilethal and male and female sterile in combination with Df(2L)TW1. Semilethal in combination with Df(2L)TW161.

(Butler et al., 2001)

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

NOT in combination with other aberrations

Intermediate second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1 : malformed phenotype penetrance 25-75%.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Shows a dose-sensitive interaction with pb^hs.PB.

(Boube et al., 1997)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Homozygous embryos are very abnormal compared to wild-type. The Malpighian tubule primordium forms but individual tubules do not bud out.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Severe morphological defect.

(Smith et al., 1993)

Associated with a dominant very weak Minute phenotype.

(Wright et al., 1976)

Stocks (2)

3189

Df(2L)TW50, cn¹/CyO, Dp(2;2)M(2)m⁺

106903

Df(2L)TW50, cn¹/CyO, Dp(2;2)M(2)m⁺

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2L)TW50 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

(Mason et al., 2004)

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Df(2L)50

(Takano and McKee, 1995, Nusslein-Volhard et al., 1984, Wright et al., 1982, Wright et al., 1976, Wright et al., 1976)

Df(2L)TW50

(Ida et al., 2009, Casso et al., 2008, Crest et al., 2007, Levine et al., 2007, Silva et al., 2006, Marygold, 2005.1.19)

Df(2L)TW⁵⁰

(Tully et al., 1992)

Df(2R)TW50

(Sonnenfeld et al., 2004)

TW50

(Hirose et al., 2001)

Name Synonyms

Deficiency (2L) Ted Wright

Secondary FlyBase IDs

References (70)

Report Sections