FlyBase Aberration Report: Dmel\Df(2L)ed1

General Information

Symbol

Df(2L)ed1

Species

D. melanogaster

Name

Deficiency (2L) echinoid

FlyBase ID

FBab0001792

Feature type

chromosomal_deletion

Also Known As

Df(2L)ed^Sz1, Df(2L)ed^Sz, Df(2L)edSz-1, Df(2L)ed^sz-1, Df(2L)ed¹

Computed Breakpoints include

24A2;24D4

Features within 24A2--24D4

Genomic Maps

JBrowse

Sequence coordinates

2L:3,606,756..3,619,097 (Df(2L)ed1:bk1)

(Cook, 2016.2.8)

2L:4,031,377..4,198,404 (Df(2L)ed1:bk2)

(Cook, 2016.2.8)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Tsunoda and Salkoff, 1995, Landecker et al., 1994, Stern and Ganetzky, 1992, Schupbach and Wieschaus, 1991, de Belle et al., 1989, Manseau and Schupbach, 1989, Bryant et al., 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

Breakpoints

24A3-24A4;24D3-24D4

(Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Tsunoda and Salkoff, 1995, Landecker et al., 1994, Schupbach and Wieschaus, 1991, de Belle et al., 1989, Manseau and Schupbach, 1989, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

24A3-24A5;24D4-24D5

(Bryant et al., 1988)

24A2-24A3;24D2-24D4

(Stern and Ganetzky, 1992)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

odd << bk1 << cutlet << fs(2)ltoQE45 << bk2 << l(2)24De

Genetic mapping information

Comments

The 2L:3606756..3619097 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the right end of odd. The right extent corresponds to the left end of Dot. FBrf0151267 mapped the left end of Df(2L)ed1 between these genes.

(Cook, 2016.2.8)

The 2L:4031377..4198404 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of ed, which published results say is deleted. The right extent corresponds to the left end of ft, which published results say is not deleted.

(Cook, 2016.2.8)

Breakpoint(s) molecularly mapped

(Butler et al., 1989)

Comments on Cytology

Proximal end of Df(2L)drm-P2 overlaps Df(2L)ed1.

(Green, 2002.2)

Left limit of break 1 from polytene analysis (FBrf0056564) Right limit of break 1 from inclusion of for (FBrf0067338) Left limit of break 2 from inclusion of ed (FBrf0047784) Right limit of break 2 from polytene analysis (FBrf0039034)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

bark

(Byri et al., 2015)

bowl

(Wang and Coulter, 1996, de Belle et al., 1993)

capu

(de Belle et al., 1993, Schupbach and Wieschaus, 1991, Wang and Lehmann, 1991, Manseau and Schupbach, 1989)

cutlet

(Jaffe and Jongens, 2001, de Belle et al., 1993)

(Bai et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, de Belle et al., 1993, Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

for

(Wang et al., 2008, Spradling et al., 1999, Sokolowski et al., 1997, BDGP Project Members, 1994-1999, de Belle et al., 1993, de Belle et al., 1989)

fs(2)ltoQE45

(Schupbach and Wieschaus, 1991)

huc2L-12

(Silva et al., 2006)

l(2)24CDa

(de Belle et al., 1993)

l(2)24CDb

(de Belle et al., 1993)

slp1

(Jaynes and Fujioka, 2004, Spradling et al., 1999, Harbecke and Lengyel, 1995, BDGP Project Members, 1994-1999, Cadigan et al., 1994, Cadigan et al., 1994, de Belle et al., 1993, Grossniklaus et al., 1992, Tearle and Nusslein-Volhard, 1987)

slp2

(Jaynes and Fujioka, 2004, Harbecke and Lengyel, 1995, Cadigan et al., 1994, Cadigan et al., 1994, Grossniklaus et al., 1992)

Ugt36A1

(BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Acsl

(BDGP Project Members, 1994-1999)

bowl

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Bryant et al., 1988, Reuter and Szidonya, 1983)

dpy

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

dw-24E

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

for

(Anreiter et al., 2021)

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

garz

(Reuter and Szidonya, 1983)

ine

(Stern and Ganetzky, 1992)

l(2)24Dc

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24Dd

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24De

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24Fa

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)24Fc

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ab

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ba

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bb

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bc

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bd

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Be

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bf

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Bg

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

l(2)25Ca

(Bryant et al., 1988, Reuter and Szidonya, 1983)

l(2)06708

(BDGP Project Members, 1994-1999)

l(2)k07315

(BDGP Project Members, 1994-1999)

l(2)k08617

(BDGP Project Members, 1994-1999)

M(2)24D

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

odd

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Pph13

(Zelhof et al., 2003)

raw

(BDGP Project Members, 1994-1999)

Reph

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

RpL27A

(Bryant et al., 1988, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

RpL37A

(Bryant et al., 1988, Reuter and Szidonya, 1983)

slf

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Su(var)2-4

(Reuter and Szidonya, 1983)

Su(var)2-8

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Reuter and Szidonya, 1983)

Su(var)25F26B

(Reuter and Szidonya, 1983)

Thor

(BDGP Project Members, 1994-1999)

tkv

(Bryant et al., 1988, Reuter and Szidonya, 1983)

Tps1

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

tutl

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (79)

Related Comments

Phenotypic Data

In combination with other aberrations

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

Heterozygotes with Df(2L)ed2 or Df(2L)M24F11 are lethal and with Df(2L)M24F-B, Df(2L)tkv2 or Df(2L)tkv3 are viable.

(Reuter and Szidonya, 1983)

NOT in combination with other aberrations

Df(2L)ed1 embryos appear normal.

(Mathew et al., 2009)

The Df(2L)ed1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(2L)ed1 results in 0.5% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

I_A and I_K currents are present in cell cultures of midline neurons prepared from Df(2L)ed1 mutants.

(Schmidt et al., 2000)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Homozygous embryos do not complete head involution, tracheae are disconnected and salivary glands are reduced in size. The hindgut is short and broad, and the Malpighian tubules are variable in length.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

P{lArB}A208.1M2 is viable over Df(2L)ed1 and P{lArB}slp1^A509 is lethal.

(Grossniklaus et al., 1992)

Homozygous lethal. Chromosome does not have a suppressor effect on w variegation of In(1)w^m4h.

(Reuter and Szidonya, 1983)

Stocks (2)

Bloomington

5330

Df(2L)ed1/CyO; P{ftz-lacC}1

Kyoto

108178

Df(2L)ed1/CyO; P{ftz-lacC}1

Notes on Origin

Discoverer

Szidonya.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Chromosome carries a separable missense mutation in the jet gene.

(Koh et al., 2006)

Transheterozygotes with slp1^Δ46G and with Df(2L)slp-Δ34B display cuticular phenotypes.

(Cadigan et al., 1994, Cadigan et al., 1994)

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

Df(2)ed^sz1.2

(Wang and Coulter, 1996)

Df(2L)^ed1

(Muraoka et al., 2018)

Df(2L)ED1

(Byri et al., 2015)

Df(2L)ed

Df(2L)ed-SZ1

(Markussen et al., 1995, Tearle and Nusslein-Volhard, 1987)

Df(2L)ed-Sz1

Df(2L)ed1

(Candia et al., 2023, Pan et al., 2022, Ribot et al., 2022, Li et al., 2020, Sawyer et al., 2020, Granados et al., 2019, Lopez-Gonzalez et al., 2019, Clough et al., 2014, Galindo et al., 2014, Fernandes and Rao, 2011, Schroeder et al., 2011, Wang et al., 2008, Crest et al., 2007, Koh et al., 2006, Silva et al., 2006, Zelhof et al., 2003, Schmidt et al., 2000)

Df(2L)ed1-sz1

(Mathew et al., 2009)

Df(2L)ed¹

(Anreiter et al., 2021, Green et al., 2002, Klingler and Gergen, 1993)

Df(2L)ed^SZ1,2

(Manseau and Schupbach, 1989)

Df(2L)ed^SZ1

(Chang et al., 2011, Dahlgaard et al., 2007, Gebelein and Mann, 2007, Cadigan et al., 1994, Cadigan et al., 1994, Clark et al., 1994, Grossniklaus et al., 1992)

Df(2L)ed^SZ

(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

Df(2L)ed^Sz-1

(Bryant et al., 1988)

Df(2L)ed^Sz1

(Alexandre and Vincent, 2003, Reuter and Szidonya, 1983)

Df(2L)ed^Sz

(Shaver et al., 1998, Sokolowski et al., 1997, de Belle et al., 1993, de Belle et al., 1991, de Belle et al., 1989)

Df(2L)ed^sZ1

(Fujioka et al., 1999)

Df(2L)ed^sz-1

(Wustmann et al., 1989, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

Df(2L)ed^sz1

(Stern and Ganetzky, 1992)

Df(2L)edSZ

(Pauli et al., 1995)

Df(2L)edSZ1

(Riechmann et al., 1997)

Df(2L)edSz-1

(Harris et al., 2003, Duffy et al., 1996, Harbecke and Lengyel, 1995, Tsunoda and Salkoff, 1995)

Df(2L)ed[S71.2]

(Wang and Lehmann, 1991)

Df(2L)edl

(Tran and Berg, 2003)

ed1

(Kim et al., 2023)

Name Synonyms

Deficiency (2L) echinoid

Secondary FlyBase IDs

FBab0022225

References (81)

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