FlyBase Aberration Report: Dmel\Df(2L)r10

General Information

Symbol

Df(2L)r10

Species

D. melanogaster

Name

FlyBase ID

FBab0001903

Feature type

chromosomal_deletion

Computed Breakpoints include

35D1;36A6-36A7

Features within 35D1--36A7

Genomic Maps

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Sequence coordinates

2L:15,434,573..15,476,957 (Df(2L)r10:bk1)

(Friedman et al., 2011.5.2)

2L:16,549,467..16,559,961 (Df(2L)r10:bk2)

(Friedman et al., 2011.5.2)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

P{hsp26-lacZ}36A

Mutagen

gamma ray

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Holmes et al., 1998, Rodriguez et al., 1996, Kania et al., 1995, Schupbach and Wieschaus, 1991)

Breakpoints

35D1-35D2;36A6-36A7

(Schupbach and Wieschaus, 1991)

35E1-35E2;36A6-36A7

(Holmes et al., 1998, Rodriguez et al., 1996, Kania et al., 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

wor << bk1 << sna << dac << bk2 << her

Genetic mapping information

Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

(Marygold et al., 2007)

Comments on Cytology

The left Df(2L)r10 breakpoint lies within genes CG4161 and sna or in the region between them, in the range 2L:15434573 .. 15476957 (R5) (Predicted cytology: 35D2).

(Friedman et al., 2011.5.2)

The right Df(2L)r10 breakpoint lies within CG5968 or CG42389 or in the region between them, in the range 2L:16549467..16559961 (R5) (Predicted cytology: 36A4-36A5) based on the following evidence.

(Friedman et al., 2011.5.2)

Ref: Ashburner et al., 1990, Genetics 126: 679--694

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0054123) Right limit of break 1 from inclusion of sna (FBrf0051973) Limits of break 2 from polytene analysis (FBrf0054123)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

beat-Ia

(Holmes and Heilig, 1999, Holmes et al., 1998, van Vactor et al., 1993)

BicC

(Schupbach and Wieschaus, 1991, Ashburner et al., 1990)

c(2)M

(Page et al., 2007)

cact

(Stronach and Perrimon, 2001, Schupbach and Wieschaus, 1991, Ashburner et al., 1990)

Ca-α1D

(Ashburner et al., 1990)

chif

(Schupbach and Wieschaus, 1991, Ashburner et al., 1990)

cni

(Ashburner et al., 1990)

crp

(Spradling et al., 1999, Roote, 1998.11.16, BDGP Project Members, 1994-1999, Ashburner et al., 1990)

CycE

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Ashburner et al., 1990)

Cyp303a1

(Ashburner et al., 1990)

dac

(Ashraf et al., 1999, BDGP Project Members, 1994-1999, Ashburner et al., 1990)

EndoGI

(Temme et al., 2009)

fzy

(Dawson et al., 1993, Ashburner et al., 1990)

Gli

(Auld et al., 1995, Ashburner et al., 1990)

heix

(Spradling et al., 1999, BDGP Project Members, 1994-1999, Ashburner et al., 1990)

l(2)35De

(Kahsai and Cook, 2018, Ashburner et al., 1990)

lace

(Ashburner et al., 1990)

mRpL4

(Ashburner et al., 1990)

ms(2)35Dj

(Roote, 2010.1.4)

ms(2)35Eb

(Kahsai and Cook, 2018, Ashburner et al., 1990)

Mtr4

(Ashburner et al., 1990)

ND-B17

(Ashburner et al., 1990)

S(ls)6

(Pepple et al., 2007)

sna

(Ashraf et al., 1999, Ashburner et al., 1990)

Syx5

(Ashburner et al., 1990)

twe

(Schupbach and Wieschaus, 1991)

wek

(Ashburner et al., 1990)

Partially deleted / disrupted

Molecular Data

Completely deleted

mRpL4

(Marygold et al., 2007)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Ashburner et al., 1990)

Cul3

(Zhu et al., 2005, Ashburner et al., 1990)

Cyt-c-d

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Cyt-c-p

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

esg

(Rodriguez et al., 1996, Kania et al., 1995, Ashburner et al., 1990)

fs(2)lto1

(Ashburner et al., 1999.10.12, Roote, 1997.12.2)

glu

(Spradling et al., 1999, Kania et al., 1995, BDGP Project Members, 1994-1999)

grp

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

her

(Li and Baker, 1998)

l(2)36Aa

(Ashburner et al., 1990)

l(2)36Ab

(Ashburner et al., 1990)

l(2)36Ac

(Ashburner et al., 1990)

l(2)36Ad

(Ashburner et al., 1990)

l(2)gl

(Mason et al., 2004)

l(2)k04206

(BDGP Project Members, 2000-, BDGP Project Members, 1994-1999)

l(2)k09033

(BDGP Project Members, 1994-1999)

l(2)k09216

(BDGP Project Members, 1994-1999)

l(2)k09834

(BDGP Project Members, 1994-1999)

l(2)k17003

(BDGP Project Members, 1994-1999)

nAChRα6

(Watson et al., 2010)

plo

(Ashburner et al., 1990)

PolD3

(Ashburner et al., 1990)

(Eriksen et al., 2000)

stc

(Zhu et al., 2005, Ashburner et al., 1990)

Su(H)

(Ashburner et al., 1990)

TfIIS

(Ashburner et al., 1990)

twe

(BDGP Project Members, 1994-1999)

Uxt

(Ashburner et al., 1990)

vas

(Ashburner et al., 1990)

vimar

(BDGP Project Members, 1994-1999)

wor

(Ashburner et al., 1990)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

Df(2L)r10/Df(2L)H20 results in almost complete lethality.

(Levine et al., 2007)

NOT in combination with other aberrations

Df(2L)r10 heterozygotes show increased dietary copper tolerance compared with wild-type.

(Norgate et al., 2010)

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2L)r10 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(2L)r10 results in 14.5% X chromosome nondisjunction and 8.5% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

In embryos heterozygous for Df(2L)r10, leading edge (LE) cells are observed in a single row; however the ring of LE cells are positioned slightly more dorsally than in wild-type and appear smaller to account for the reduced area of the amnioserosa tissue.

(Stronach and Perrimon, 2001)

Df(2L)r10 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile.

(Sawamura et al., 2000)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Stocks (3)

1491

106710

103272

Df(2L)r10, cn¹ / CyO, Duox^Cy dpy^lv1 pr¹ cn²

Notes on Origin

Discoverer

Y. Hiromi.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

45490

(Eriksen et al., 2000)

Df(2)r10

(Anderson et al., 2006)

DfKu80¹

(Melnikova et al., 2005)

r10

(Ashburner et al., 1999.10.12)

Name Synonyms

Secondary FlyBase IDs

References (72)

Report Sections

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