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General Information
Symbol
Df(2L)r10
Species
D. melanogaster
Name
FlyBase ID
FBab0001903
Feature type
Computed Breakpoints include
Sequence coordinates
2L:15,434,573..15,476,957 (Df(2L)r10:bk1)
2L:16,549,467..16,559,961 (Df(2L)r10:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

wor << bk1 << sna << dac << bk2 << her

Genetic mapping information
Comments

This deletion removes a single ribosomal protein-coding gene (though other genes are also removed).

Comments on Cytology

The left Df(2L)r10 breakpoint lies within genes CG4161 and sna or in the region between them, in the range 2L:15434573 .. 15476957 (R5) (Predicted cytology: 35D2).

The right Df(2L)r10 breakpoint lies within CG5968 or CG42389 or in the region between them, in the range 2L:16549467..16559961 (R5) (Predicted cytology: 36A4-36A5) based on the following evidence.

Ref: Ashburner et al., 1990, Genetics 126: 679--694

Left limit of break 1 from polytene analysis (FBrf0054123) Right limit of break 1 from inclusion of sna (FBrf0051973) Limits of break 2 from polytene analysis (FBrf0054123)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Df(2L)r10/Df(2L)H20 results in almost complete lethality.

NOT in combination with other aberrations

Df(2L)r10 heterozygotes show increased dietary copper tolerance compared with wild-type.

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

The Df(2L)r10 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

Heterozygosity for Df(2L)r10 results in 14.5% X chromosome nondisjunction and 8.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

In embryos heterozygous for Df(2L)r10, leading edge (LE) cells are observed in a single row; however the ring of LE cells are positioned slightly more dorsally than in wild-type and appear smaller to account for the reduced area of the amnioserosa tissue.

Df(2L)r10 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile.

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

Shows no maternal enhancement of dpphr4.

Midgut development of mutant embryos is wild type.

Stocks (3)
Notes on Origin
Discoverer

Y. Hiromi.

 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (5)
References (72)