FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(2R)Dll-MP
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General Information
Symbol
Df(2R)Dll-MP
Species
D. melanogaster
Name
FlyBase ID
FBab0001942
Feature type
chromosomal_deletion
Also Known As
DllMP, Df(2R)DllMP, Df(2R)Ba-MP, Df(2R)Ba
Computed Breakpoints include

60E1-60E2;60E6

Features within 60E1--60E6
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
gamma ray
(Sunkel and Whittle, 1987)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Pauli et al., 1995, Germeraad et al., 1992)
Breakpoints

60E1-60E2;60E5-60E6

(Pauli et al., 1995, Germeraad et al., 1992)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

E(wa) << bk1 << Dll << bk2 << RpL19

Genetic mapping information
Comments

Deletion removing entire Dll transcription unit.

(Cohen et al., 1993)

entire putative transcription unit deleted. Deleted for the region from approximately coordinate 90 kb through 180 kb and beyond on the molecular map of Cohen et al. Deletion removes the entire Dll coding region <up>Cohen, Bronner, Kuttner, Jurgens and Jackle, 1989, Nature (London), 338: 432-34</up>.

Comments on Cytology

Ref: Cohen et al., 1989, Nature 338: 432--434

(Germeraad et al., 1992)

Cytologically normal.

(Sunkel and Whittle, 1987)

Limits of break 1 from polytene analysis (FBrf0056560) Left limit of break 2 from polytene analysis (citation unavailable) Right limit of break 2 from polytene analysis (FBrf0056560)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Dll
(Castelli-Gair and Akam, 1995, Gindhart and Kaufman, 1995)
egg
(Clough et al., 2007)
Eps-15
(Koh et al., 2007)
key
(Rutschmann et al., 2000)
red-shirt
(Elrod-Erickson et al., 2000)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
l(2)gl
(Mason et al., 2004)
RpL19
(Hart et al., 1993)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(3R)sbd45 dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. Df(2L)al dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes. Df(2R)M60E dominantly enhances the transformation of arista to leg phenotype seen in Df(2R)Dll-MP heterozygotes.

    (Fauvarque et al., 2001)
    NOT in combination with other aberrations

    Df(2R)Dll-MP mutant embryos have fewer neurons and fewer support cells in the dorsal organ (DO) and terminal organ than wild type animals. No cell death is seen (TUNEL staining) and the remaining neurons exhibit aberrant morphologies. The DO dendrites are loosely associated rather than tightly bundled and the axons of the remaining DO neurons form a single fascicle projected towards the subesophageal ganglion. No fascicles target the larval antennal lobe (LAL). Df(2R)Dll-MP mutants also exhibit loss of a primary axon bundle that emanates from the mushroom bodies and projects along the dorsal and ventral tracts of the supraesophageal commissure.

    In Df(2R)Dll-MP mutant embryos the brain commissures are defective and the microtubule-associated Futsch protein is consistently mislocalised. One of the three supraesophageal commissures seen in wild type is missing in Df(2R)Dll-MP mutants. Both of the primary axon tracts that make up the subesophageal commissure are also missing.

    (Plavicki et al., 2012)

    Heterozygotes show a partial transformation of the arista to leg.

    (Fauvarque et al., 2001)

    No effect on the eye pigment phenotype of wT81.

    (Netter et al., 1998)

    Mutation does not affect the level of w expression in ph-plac+3 flies.

    (Fauvarque et al., 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Recessive lethal. Heterozygote shows partial transformation of aristae to tarsal segments. Dominant phenotype suppressed in either Pcl10 or Df(2R)en28 heterozygotes. Df(2R)Dll/+ shows almost complete suppression of the extra-sex combs phenotypes of Pc4/+, PcT7/+, Pcl10/+, Pcl11/+, AntpScx/+, Msc/+, and MscT3/+.

    Stocks (2)
    Notes on Origin
    Discoverer

    Moscoso del Prado.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2R)Dll-MP chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the 2L TAS array on the chromosome is missing (as assayed by in situ hybridization) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,wvar}2Lt.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (13)
    References (36)