FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(2R)M41A10
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General Information
Symbol
Df(2R)M41A10
Species
D. melanogaster
Name
Deficiency (2R) Minute 41A
FlyBase ID
FBab0001992
Feature type
chromosomal_deletion
Also Known As
Df(2R)MS210, Df(2R)M-S210, M(2)S10, Df(2R)MS2-10, MS2-10, Df(2R)M-S2-10, Df(2R)M-S10
Computed Breakpoints include

h38R;h46

Features within h38R--h46
Genomic Maps
Sequence coordinates
2R:1..1 (Df(2R)M41A10:bk1)
(Cook, 2016.2.8)
2R:5,177,965..5,259,004 (Df(2R)M41A10:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Duffy et al., 1996, Koryakov and Zhimulev, 1996, Pauli et al., 1995, Belyaeva and Zhimulev, 1991, Dimitri, 1991, Cicchetti and Loverre, 1988)
Breakpoints

41A;h38R-h46

(Cicchetti and Loverre, 1988)

h38R;41A

(Belyaeva and Zhimulev, 1991)

h38R;h46

(Dimitri, 1991)

41A;41A

(Duffy et al., 1996, Pauli et al., 1995)

h38R;41E1-41E2

(Koryakov and Zhimulev, 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

l(2)40Fg << bk1 << Rsp << l(2)IR23 << bk2 << stw

Genetic mapping information
Comments

The 2R:5177965..5259004 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of Nipped-A, which published results say is deleted. The right extent corresponds to the left end of d4, which published results say is not deleted.

(Cook, 2016.2.8)

The left extent of the deleted region in Df(2R)M41A10 is shown as the release 6 coordinate 2R:1 , the left end of the 2R genome assembly, because Df(2R)M41A10 extends into 2R heterochromatin.

(Cook, 2016.2.8)
Comments on Cytology

Lacks 2R heterochromatin.

(Sinclair et al., 1992)

Most of the centric heterochromatin on 2R is deleted.

(Ganetzky, 1977)

Mitotic prophase preparations of Df(2R)M41A10 clearly show that the proximal 2R heterochromatin is missing

(Hilliker and Holm, 1975)

Limits of break 1 from polytene analysis (FBrf0053437) Left limit of break 2 from inclusion of RpL38 (FBrf0027524) Right limit of break 2 from polytene analysis (FBrf0049871)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
CG17486
(Myster et al., 2004)
CG17683
(Myster et al., 2004)
IntS3
(Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997)
l(2)41Ab
(Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)
l(2)41Ae
(Rollins et al., 1999, Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)
l(2)309
(Myster et al., 2004)
l(2)IR4
(Dimitri et al., 1997)
l(2)IR24
(Dimitri et al., 1997)
l(2)IR30
(Dimitri et al., 1997)
l(2)NC30
(Myster et al., 2004)
l(2)NC83
(Myster et al., 2004)
l(2)NC85
(Myster et al., 2004)
l(2)NC133
(Myster et al., 2004)
l(2)NC192
(Myster et al., 2004)
l(2)NC204
(Marygold et al., 2005, Myster et al., 2004)
Nipped-A
(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Rollins et al., 1999, Duffy et al., 1996, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Sharp et al., 1985, Ganetzky, 1977, Hilliker, 1976)
Nipped-B
(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Corradini et al., 2003, Rollins et al., 1999)
p120ctn
(Myster et al., 2004)
rl
(Myster et al., 2004, Corradini et al., 2003, Zhang et al., 1999, Eberl et al., 1993, Lyttle, 1989, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975, Morgan et al., 1941, Curry, 1939)
RNASEK
(Myster et al., 2004)
RpL38
(Gambetta and Müller, 2009.8.18, Marygold et al., 2005, Myster et al., 2004, Rollins et al., 1999, Duffy et al., 1996, Eberl et al., 1993, Lyttle, 1989, Cicchetti and Loverre, 1988, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)
st
(Cicchetti and Loverre, 1988)
Stlk
(Myster et al., 2004)
uex
(Marygold et al., 2005, Myster et al., 2004, Dimitri et al., 1997, Eberl et al., 1993, Lyttle, 1989, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)
Yeti
(Messina et al., 2014, Eberl et al., 1993, Lyttle, 1989, Ganetzky, 1977, Hilliker, 1976, Hilliker and Holm, 1975)
Partially deleted / disrupted
Molecular Data
Completely deleted
Atf6
(Myster et al., 2004)
CG3107
(Myster et al., 2004)
CG12547
(Myster et al., 2004)
CG14464
(Myster et al., 2004)
CG17486
(Myster et al., 2004)
CG17528
(Myster et al., 2004)
conu
(Myster et al., 2004)
CR41440
(Myster et al., 2004)
gus
(Myster et al., 2004)
Nipped-A
(Myster et al., 2004)
Nipped-B
(Myster et al., 2004)
p120ctn
(Myster et al., 2004)
rl
(Myster et al., 2004)
RpL38
(Marygold et al., 2007)
Stlk
(Myster et al., 2004)
TpnC41C
(Myster et al., 2004)
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
ap
(Gambetta and Müller, 2009.8.18, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Cicchetti and Loverre, 1988, Ganetzky, 1977, Hilliker and Holm, 1975)
Bl
(Cicchetti and Loverre, 1988)
BubR1
(Myster et al., 2004)
cn
(Cicchetti and Loverre, 1988)
crc
(Hilliker and Holm, 1975)
kune
(Gambetta and Müller, 2009.8.18)
l(2)40Fa
(Hilliker and Holm, 1975)
l(2)40Fg
(Hilliker and Holm, 1975)
l(2)309
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)09851
(Gambetta and Müller, 2009.8.18, Corradini et al., 2003)
l(2)Co
(Cicchetti and Loverre, 1988)
l(2)IR4
(Coulthard et al., 2010)
l(2)k03002a
(Corradini et al., 2003)
l(2)k07312b
(Corradini et al., 2003)
l(2)L10
(Coulthard et al., 2010)
l(2)NC12
(Myster et al., 2004)
l(2)NC14
(Myster et al., 2004)
l(2)NC30
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)NC45
(Myster et al., 2004)
l(2)NC47
(Myster et al., 2004)
l(2)NC83
(Coulthard et al., 2010, Coulthard et al., 2010)
l(2)NC114
(Myster et al., 2004)
l(2)NC139
(Myster et al., 2004)
l(2)NC148
(Myster et al., 2004)
l(2)NC195
(Coulthard et al., 2010)
lt
(Cicchetti and Loverre, 1988, Hilliker and Holm, 1975)
mle
(Cicchetti and Loverre, 1988)
Not3
(Gambetta and Müller, 2009.8.18, Myster et al., 2004)
pk
(Cicchetti and Loverre, 1988)
pr
(Cicchetti and Loverre, 1988)
ptc
(Sturtevant, 1948)
Rsp
(Eberl et al., 1993)
stw
(Sickmann et al., 2017, Gambetta and Müller, 2009.8.18, Koryakov and Zhimulev, 1996, Eberl et al., 1993, Cicchetti and Loverre, 1988, Sharp et al., 1985, Ganetzky, 1977, Hilliker and Holm, 1975, Curry, 1939)
sxc
(Gambetta and Müller, 2009.8.18, Gambetta et al., 2009, Sinclair et al., 2009, Myster et al., 2004)
tri
(Hilliker and Holm, 1975)
vlc
(Gambetta and Müller, 2009.8.18, Myster et al., 2004, Corradini et al., 2003)
Molecular Data
 
BubR1
(Myster et al., 2004)
d4
(Myster et al., 2004)
Not3
(Myster et al., 2004)
sxc
(Myster et al., 2004)
vlc
(Myster et al., 2004)
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (3)
Phenotypic Data
In combination with other aberrations

Partially sensitive to segregation distortion by In(2R)SD5.

(Ganetzky, 1977)

Lethal in combination with Df(2R)M41A50j.

(Arvelighetsinstitutten, University)

Lethal in combination with Df(2R)M41A, Df(2R)M41A4, Df(2R)M41A8 or Df(2R)M41A-vg11.

(Curry, 1939)
NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 64% of run3 heterozygotes.

(Duffy et al., 1996)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

(Pauli et al., 1995)

Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 13 hours.

(Ferrus, 1975)

Heterozygotes show a thin bristled Minute phenotype. Homozygotes do not survive.

(Hilliker and Holm, 1975)

Dominant enhancer of variegation.

(Lindsley et al., 1960)

homozygous lethal Long-bristled Minute; readily classifiable. Enhances variegation of white mottleds and brown Variegateds to same extent as removal of a Y chromosome. Causes abnormal development of hybrids with D.simulans (e.g., melanotic tumors, extra organs, missing organs, death).

Stocks (2)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The Df(2R)M41A10 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)M41A10 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

(Mason et al., 2004)

"Deletes or disrupts l(2)41Ae" was stated as revision. "Deletes or disrupts Nipped-A" was stated as revision. "Does not delete or disrupt stw" was stated as revision. "Does not delete or disrupt ap" was stated as revision.

(Koryakov and Zhimulev, 1996)

Used to enhance variegation.

(Belyaeva and Zhimulev, 1991)
Synonyms and Secondary IDs (25)
References (63)