FlyBase Aberration Report: Dmel\Df(2R)en-A

General Information

Symbol

Df(2R)en-A

Species

D. melanogaster

Name

Deficiency (2R) engrailed

FlyBase ID

FBab0002173

Feature type

chromosomal_deletion

Also Known As

Df(2R)enA, Df(2R)en^-A

Computed Breakpoints include

47D3;48A5

Features within 47D7--48B2 (Estimated cytology)

Genomic Maps

JBrowse

Sequence coordinates

2R:11,155,185..11,214,749 (Df(2R)en-A:bk1)

(Cook et al., 2010.2.12)

2R:11,621,884..11,644,257 (Df(2R)en-A:bk2)

(Cook et al., 2010.2.12)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Tp(1;2)TE47EFb

(Gubb, 1985)

Mutagen

X ray

gamma ray

(Gubb, 1985)

Class of aberration (relative to wild type)

chromosomal_deletion

(Cook et al., 2010.2.12, FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Sinclair et al., 1998, Duffy et al., 1996, Humphreys et al., 1996, Chase and Baker, 1995, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Gubb, 1985, Eberlein and Russell, 1983, Bownes and Roberts, 1981)

Breakpoints

47D3;48B4-48B5

(Bownes and Roberts, 1981)

47D3;48B2-48B5

(Chase and Baker, 1995, Schupbach and Wieschaus, 1989, Eberlein and Russell, 1983)

47D3;48A4-48A5

(Sinclair et al., 1998)

47D3;48A5-48A6

(Duffy et al., 1996, Humphreys et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Gubb, 1985)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

l(2)10425 << bk1 << sha << bk2 << qvr

Genetic mapping information

Comments

Comments on Cytology

The left Df(2R)en-A breakpoint lies within CG13230 or shn or in the region between them, and lies in the range 2R:7042690..7102254 (R5) (predicted cytology: 47D5-47D7).

(Cook et al., 2010.2.12)

The right Df(2R)en-A breakpoint lies within CG9005 or CG9003 or in the region between them, and lies in the range 2R:7509389..7531762 (R5) (predicted cytology: 48A3-48B2).

(Cook et al., 2010.2.12)

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Limits of break 1 from polytene analysis (FBrf0036848) Left limit of break 2 from polytene analysis (FBrf0043525) Right limit of break 2 from polytene analysis (FBrf0100633)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (96)

Related Comments

Phenotypic Data

In combination with other aberrations

Suppresses position effect variegation (PEV) at the w locus caused by In(1)w^m4, PEV at the B locus caused by Dp(1;Y)Bar^SCV, PEV at the Sb locus caused by T(2;3)Sb^V and PEV at the bw locus caused by In(2R)bw^VDe2.

(Sinclair et al., 1998)

Suppressor of In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

NOT in combination with other aberrations

Homozygous follicle cell clones show epithelial defects, including stacking of follicle cells.

(Duchi et al., 2010)

Heterozygosity for Df(2R)en-A results in 0.9% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Defective in gonad assembly.

(Warrior, 1994)

Stocks (2)

190

108895

Notes on Origin

Discoverer

Ashburner.

The stock contains a second-site deletion uncovering l(2)gl.

(Roegiers et al., 2009)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(2R)en-A chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)en-A overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

(Mason et al., 2004)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Df (VHL)

(Irisarri et al., 2009)

Df(2)enA

(Epper and Sanchez, 1983)

Df(2R)en-^A

(Abrell et al., 2000)

Df(2R)en-A

(Kato et al., 2022, Tan et al., 2020, Marcogliese et al., 2017, Ruan et al., 2017, Clough et al., 2014, Fernandes and Rao, 2011, Grillo et al., 2011, Watson et al., 2011, Cook et al., 2010.2.12, Duchi et al., 2010, Irisarri et al., 2009, Roegiers et al., 2009, Kucherenko et al., 2008, Crest et al., 2007, Holmes et al., 2006)

Df(2R)en^-A

(Wustmann et al., 1989, Gubb, 1985)

Df(2R)en^A

(Chase and Baker, 1995)

Df(2R)enA

(Bergland et al., 2012, Srivastava et al., 2002, Tanda, 1998.3.18, Bhojwani et al., 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

Df(en)-A

(Bownes and Roberts, 1981)

en^A

(Eberlein and Russell, 1983)

Name Synonyms

Deficiency (2R) engrailed

Secondary FlyBase IDs

References (60)

Report Sections

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