FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(2R)vg-B
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General Information
Symbol
Df(2R)vg-B
Species
D. melanogaster
Name
Deficiency (2R) vestigial-Beaded
FlyBase ID
FBab0002233
Feature type
chromosomal_deletion
Also Known As
Df(2R)vgB, vgB, Df(2R)vgB
Computed Breakpoints include

49D3-49D4;50A2

Features within 49D3--50A2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Price et al., 1997, Abu-Issa and Cavicchi, 1996, Mulligan et al., 1996, Bilder and Scott, 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Granadino et al., 1992, Rabinow et al., 1991, Brunk and Adler, 1990, Rabinow and Birchler, 1990, Bownes and Roberts, 1981)
Breakpoints

49D3-49D4;50A2-50A3

(Abu-Issa and Cavicchi, 1996, Brunk and Adler, 1990, Bownes and Roberts, 1981)

49D;50A

(Rabinow and Birchler, 1990)

49C1-49C2;49E2-49E3

(Rabinow et al., 1991)

49D3-49D4;50A2-50A5

(Granadino et al., 1992)

49D3-49D4;49F15-50A3

(Price et al., 1997, Mulligan et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Wu and Howe, 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

NacĪ± << bk1 << bic << sie << bk2 << drk

Genetic mapping information
Comments
Comments on Cytology

Uncovers the distal, but not the proximal, breakpoint of the In(2R)Arp1 inversion.

(Brunk et al., 1991)

Limits of break 1 from polytene analysis (FBrf0036848) Left limit of break 2 from polytene analysis (FBrf0036848) Right limit of break 2 from polytene analysis (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
AspRS
(Wu and Howe, 1995, BDGP Project Members, 1994-1999, Lasko and Pardue, 1988)
bic
(Markesich et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999, Lasko and Pardue, 1988, Tearle and Nusslein-Volhard, 1987)
Cap-G
(Dej et al., 2004, Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
Dp
(Royzman et al., 1997, Hao et al., 1995, Lasko and Pardue, 1988)
l(2)49Dc
(Wu and Howe, 1995, Lasko and Pardue, 1988)
l(2)49Fa
(Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
l(2)49Fb
(Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
l(2)49Fg
(Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
l(2)49Fh
(Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
l(2)49Fj
(Hao et al., 1995, Lasko and Pardue, 1988)
l(2)49Fl
(Hao et al., 1995, Lasko and Pardue, 1988)
l(2)49Fm
(Hao et al., 1995, Lasko and Pardue, 1988)
l(2)49Fn
(Lasko and Pardue, 1988)
l(2)49Fo
(Hao et al., 1995, Lasko and Pardue, 1988)
l(2)k05722
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k09328
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k17019a
(BDGP Project Members, 1994-1999)
Mdr49
(Wu and Howe, 1995)
Orc3
(Hao et al., 1995, Wu and Howe, 1995, Boynton and Tully, 1992, Lasko and Pardue, 1988)
Psc
(Spradling et al., 1999, Harbecke and Lengyel, 1995, Wu and Howe, 1995, BDGP Project Members, 1994-1999, Cheng et al., 1994, Simon et al., 1992, Adler et al., 1989, Lasko and Pardue, 1988, Tearle and Nusslein-Volhard, 1987, Jurgens, 1985)
seq
(Brenman et al., 2001, Hao et al., 1995, Wu and Howe, 1995, Lasko and Pardue, 1988)
sie
(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)
Su(z)2
(Spradling et al., 1999, Wu and Howe, 1995, BDGP Project Members, 1994-1999, Cheng et al., 1994)
ValRS
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
vg
(Simmonds et al., 1997, Staveley et al., 1995, Wu and Howe, 1995, Brunk et al., 1991, Rabinow and Birchler, 1990, Williams et al., 1990, Lasko and Pardue, 1988)
Partially deleted / disrupted
Molecular Data
Completely deleted
NAT1
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Lethal in combination with Df(2R)vg62.

    (Wu and Howe, 1995)

    No effect on In(1)wm4h position-effect variegation.

    (Wustmann et al., 1989)
    NOT in combination with other aberrations

    Heterozygous females produce embryos with defects in segmentation and head structure, and also a variable and occasionally very high proportion of undeveloped eggs. Bicaudal embryos are not seen.

    (Markesich et al., 2000)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Homozygous lethal. Heterozygotes show occasional nicking of the wings.

    (Abu-Issa and Cavicchi, 1996)

    Midgut development of mutant embryos is wild type.

    (Bilder and Scott, 1995)

    Homozygous embryos are very abnormal compared to wild-type. Differentiation of Malpighian tubule material is variable.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Dominant enhancer of nodDTW.

    (Rasooly, 1995)

    Does not exhibit dominant flightlessness.

    (Cripps and Sparrow, 1989)

    Enhances BicD in heterozygotes (Mohler and Wieschaus, 1986) homozygous lethal

    Stocks (3)
    Notes on Origin
    Discoverer

    Bridges, 11 April 1928.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2R)vg-B chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)vg-B overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (12)
    References (79)