FlyBase Aberration Report: Dmel\Df(3L)kto2

General Information

Symbol

Df(3L)kto2

Species

D. melanogaster

Name

Deficiency (3L) kohtalo

FlyBase ID

FBab0002383

Feature type

chromosomal_deletion

Also Known As

Df(3L)kto², Df(3L)JK18, Df(2R)kto²

Computed Breakpoints include

76B1-76B2;76D5

Features within 76B1--76D5

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

P-element activity

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Hernandez et al., 1996, Dorer et al., 1995, LaJeunesse and Shearn, 1995, Tsunoda and Salkoff, 1995)

Breakpoints

76B1-76B2;76D5

(LaJeunesse and Shearn, 1995, Tsunoda and Salkoff, 1995)

76B;76D

(Dorer et al., 1995)

[];76D5

(Hernandez et al., 1996)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << kto << bk2 << fln

Genetic mapping information

Comments

Comments on Cytology

All limits from polytene analysis (FBrf0080459)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

asf1

(Cooper et al., 2010, Zhu et al., 2005)

ash1

(Cooper et al., 2010, Bantignies et al., 2000, Sen et al., 1998, Gross and McGinnis, 1996, Tripoulas et al., 1996, Veraksa and McGinnis, 1996, LaJeunesse and Shearn, 1995)

cyc

(Rutila et al., 1998)

Deaf1

(Cooper et al., 2010, Gross and McGinnis, 1996, Veraksa and McGinnis, 1996)

Gyc76C

(Patel et al., 2012, Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

kto

(Cooper et al., 2010, Zhu et al., 2005, Veraksa et al., 2002, Gross and McGinnis, 1996)

l(3)76BDd

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

l(3)76BDg

(Cooper et al., 2010, Cook, 2008.12.1, Szeged Stock Center, 1998-)

l(3)76BDh

(Cooper et al., 2010, Cook, 2008.12.1)

l(3)76BDj

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

l(3)76BDm

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005, Spradling et al., 1999)

l(3)76BDt

(Cooper et al., 2010, Zhu et al., 2005)

l(3)S093411

(Szeged Stock Center, 1998-)

l(3)S145709

(Szeged Stock Center, 1998-)

Ltn1

(Cooper et al., 2010, Zhu et al., 2005)

Mi-2

(Cooper et al., 2010, Spradling et al., 1999, Kennison, 1995.6.21)

Papss

(Cooper et al., 2010, Zhu et al., 2005)

pip

(Cooper et al., 2010, Sen et al., 1998)

Rab8

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

serp

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

SREBP

(Cooper et al., 2010, Cook, 2008.12.1)

Su(Tpl)

(Cooper et al., 2010, Zhu et al., 2005, Dorer et al., 1995)

Su(z)12

(Cooper et al., 2010, Zhu et al., 2005, Zirin and Mann, 2004, Birve et al., 1999)

Taf6

(Cooper et al., 2010)

trc

(Cooper et al., 2010, Zhu et al., 2005, Veraksa et al., 2002, Geng et al., 2000, Szeged Stock Center, 1998-)

Trpml

(Cooper et al., 2010, Cook, 2008.12.1, Zhu et al., 2005)

verm

(Cooper et al., 2010, Cook, 2008.12.1)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

(Kennison, 2006.7.21)

fang

(Myat et al., 2005)

fln

(Hernandez et al., 1996)

gloin

(Myat et al., 2005)

Gyc76C

(Myat et al., 2005)

l(3)ry119

(Kennison, 1993.7.1)

Wow

(Birchler et al., 1994)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

Fails to complement Df(3L)fln1 and Df(3L)VW3.

(Vigoreaux et al., 1998)

NOT in combination with other aberrations

Only the distal tip of the salivary gland turns in embryos homozygous for Df(3L)kto2 by stage 14.

(Jattani et al., 2009)

Df(3L)kto2 embryos show defects in tracheal cell migration.

(Myat et al., 2005)

Dominantly enhances the Kr^If-1/+ eye phenotype.

(Carrera et al., 1998)

No effect on the eye pigment phenotype of w^T81.

(Netter et al., 1998)

Homozygous lethal. Heterozygotes have longer locomotor rhythm periods than normal.

(Rutila et al., 1998)

Flies have a normal flight index.

(Vigoreaux et al., 1998)

Does not rescue the lethal phenotype of three doses of Tpl⁺.

(Dorer et al., 1995)

Mutation changes the level of w expression in ph-p^lac+3 flies; eye colour is darker.

(Fauvarque et al., 1995)

Only 13% of neurons in Df(3L)kto2 flies have a transient K⁺ current.

(Tsunoda and Salkoff, 1995)

Stocks (2)

3617

107131

Notes on Origin

Discoverer

Kennison, 1987.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

The Df(3L)kto2 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

(Mason et al., 2004)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Df(2R)kto²

(Treisman, 2001, Mihaly et al., 1997)

Df(3)TAF_II60

(Zhou et al., 1998)

Df(3L)JK18

(Bantignies et al., 2000, Tripoulas et al., 1996, LaJeunesse and Shearn, 1995, Tsunoda and Salkoff, 1995, Tsunoda and Salkoff, 1995)

Df(3L)KT02

(Zhou et al., 1998)

Df(3L)Kto2

(Feng et al., 2003)

Df(3L)kto

(Birve et al., 1999)

Df(3L)kto2

(Ribot et al., 2022, Thimgan et al., 2015, Cuykendall et al., 2014, Patel et al., 2012, Cooper et al., 2010, Jattani et al., 2009, Cook, 2008.12.1, Goodliffe et al., 2007, Kennison, 2006.7.21, Aoyagi and Wassarman, 2001)

Df(3L)kto²

(Veraksa et al., 2002, Lopez et al., 2001, Reedy et al., 2000, Netter et al., 1998, Gross and McGinnis, 1996, Hernandez et al., 1996, Dorer et al., 1995, Fauvarque et al., 1995)

Name Synonyms

Deficiency (3L) kohtalo

Secondary FlyBase IDs

References (65)

Report Sections

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