FB2020_06, released Dec 22, 2020

Aberration: Dmel\Df(3R)D605

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General Information
Symbol
Df(3R)D605
Species
D. melanogaster
Name
FlyBase ID
FBab0002515
Feature type
chromosomal_deletion
Computed Breakpoints include

97E3;98A5

Features within 97E2--98A4 (Estimated cytology)
Genomic Maps
Sequence coordinates
3R:27,093,906..27,095,602 (Df(3R)D605:bk1)
(Cook et al., 2010.2.12)
3R:27,516,589..27,532,761 (Df(3R)D605:bk2)
(Cook et al., 2010.2.12)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to wild type)
chromosomal_deletion
(Cook et al., 2010.2.12, FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Thomas et al., 1991)
Breakpoints

97E3;98A5

(Thomas et al., 1991)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

spz << bk1 << pll << bk2

Genetic mapping information
Comments
Comments on Cytology

The left Df(3R)D605 breakpoint lies within CG14258 or CG14259 or in the region between them, and lies in the range 3R:22919628..22921324 (R5) (predicted cytology: 97E2).

(Cook et al., 2010.2.12)

The right Df(3R)D605 breakpoint lies within CG13972 or CG12885 or in the region between them, and lies in the range 3R:23342311..23358483 (R5) (predicted cytology: 98A3-98A4).

(Cook et al., 2010.2.12)

All limits from polytene analysis (FBrf0053814)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
eater
(Kocks et al., 2005)
l(3)mbt
(Ambrus et al., 2009, Yohn et al., 2003)
pll
(Hecht and Anderson, 1993)
Ser
(Jonsson and Knust, 1996, Couso et al., 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Df(3R)Tl-I/Df(3R)D605 flies are viable and fertile.

(Kocks et al., 2005)

Df(3R)Tl-I/Df(3R)D605 flies show a normal humoral response.

(Kocks et al., 2005)

Df(3R)Tl-I/Df(3R)D605 flies show strongly impaired levels of phagocytosis of gram-positive bacteria compared to wild-type or heterozygous controls. These flies also show an impairment in phagocytosis of gram-negative bacteria, although to a lesser extent.

(Kocks et al., 2005)

Df(3R)Tl-I/Df(3R)D605 hemocytes show impaired levels of phagocytosis of both gram-positive and gram-negative bacteria, but show wild-type levels of phagocytosis of india ink carbon particles. These hemocytes appear to adhere less tightly to the larval cuticle than wild-type hemocytes.

(Kocks et al., 2005)

After feeding on gram-negative bacteria, Df(3R)Tl-I/Df(3R)D605 flies die more rapidly than wild-type flies. The hemolymph of these flies contains about a 10,000-fold increase in bacterial number compared to wild-type flies.

(Kocks et al., 2005)
NOT in combination with other aberrations

Df(3R)D605/Df(3R)Tl-I flies ("eater null" flies) exhibit increased susceptibility to R.oryzae as compared to control wild-type flies.

(Chamilos et al., 2008)

The Df(3R)D605 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(3R)D605 results in 0.0% X chromosome nondisjunction and 0.7% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

(Harris et al., 2003)

Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

SerRX82/Df(3R)D605 hemizygotes fail to establish an organising centre at the dorsoventral boundary in the wing disc; wings fail to form. Scer\GAL4h-540.3-mediated expression of SerUAS.cSa in second/early third larval instar partially restores wing formation (about half normal length but lack any marginal differentiation).

(Jonsson and Knust, 1996)

Df(3R)D605/SerRX106 flies have wings reduced to stumps with no margin.

(Couso et al., 1995)
Stocks (4)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (4)
References (39)