Df(3R)Tl-I/Df(3R)D605 flies are viable and fertile.

Df(3R)Tl-I/Df(3R)D605 flies show a normal humoral response.

Df(3R)Tl-I/Df(3R)D605 flies show strongly impaired levels of phagocytosis of gram-positive bacteria compared to wild-type or heterozygous controls. These flies also show an impairment in phagocytosis of gram-negative bacteria, although to a lesser extent.

Df(3R)Tl-I/Df(3R)D605 hemocytes show impaired levels of phagocytosis of both gram-positive and gram-negative bacteria, but show wild-type levels of phagocytosis of india ink carbon particles. These hemocytes appear to adhere less tightly to the larval cuticle than wild-type hemocytes.

After feeding on gram-negative bacteria, Df(3R)Tl-I/Df(3R)D605 flies die more rapidly than wild-type flies. The hemolymph of these flies contains about a 10,000-fold increase in bacterial number compared to wild-type flies.

Df(3R)D605/Df(3R)Tl-I flies ("eater null" flies) exhibit increased susceptibility to R.oryzae as compared to control wild-type flies.

The Df(3R)D605 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

Heterozygosity for Df(3R)D605 results in 0.0% X chromosome nondisjunction and 0.7% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome.

Ser^RX82/Df(3R)D605 hemizygotes fail to establish an organising centre at the dorsoventral boundary in the wing disc; wings fail to form. Scer\GAL4^h-540.3-mediated expression of Ser^UAS.cSa in second/early third larval instar partially restores wing formation (about half normal length but lack any marginal differentiation).

Df(3R)D605/Ser^RX106 flies have wings reduced to stumps with no margin.