97E3;98A5
spz << bk1 << pll << bk2
Df(3R)Tl-I/Df(3R)D605 flies are viable and fertile.
Df(3R)Tl-I/Df(3R)D605 flies show a normal humoral response.
Df(3R)Tl-I/Df(3R)D605 flies show strongly impaired levels of phagocytosis of gram-positive bacteria compared to wild-type or heterozygous controls. These flies also show an impairment in phagocytosis of gram-negative bacteria, although to a lesser extent.
Df(3R)Tl-I/Df(3R)D605 hemocytes show impaired levels of phagocytosis of both gram-positive and gram-negative bacteria, but show wild-type levels of phagocytosis of india ink carbon particles. These hemocytes appear to adhere less tightly to the larval cuticle than wild-type hemocytes.
After feeding on gram-negative bacteria, Df(3R)Tl-I/Df(3R)D605 flies die more rapidly than wild-type flies. The hemolymph of these flies contains about a 10,000-fold increase in bacterial number compared to wild-type flies.
Df(3R)D605/Df(3R)Tl-I flies ("eater null" flies) exhibit increased susceptibility to R.oryzae as compared to control wild-type flies.
The Df(3R)D605 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).
Heterozygosity for Df(3R)D605 results in 0.0% X chromosome nondisjunction and 0.7% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
Causes inviability or low viability in hybrid females when heterozygous with D.simulans chromosome.
SerRX82/Df(3R)D605 hemizygotes fail to establish an organising centre at the dorsoventral boundary in the wing disc; wings fail to form. Scer\GAL4h-540.3-mediated expression of SerUAS.cSa in second/early third larval instar partially restores wing formation (about half normal length but lack any marginal differentiation).
Df(3R)D605/SerRX106 flies have wings reduced to stumps with no margin.
The left Df(3R)D605 breakpoint lies within CG14258 or CG14259 or in the region between them, and lies in the range 3R:22919628..22921324 (R5) (predicted cytology: 97E2).
The right Df(3R)D605 breakpoint lies within CG13972 or CG12885 or in the region between them, and lies in the range 3R:23342311..23358483 (R5) (predicted cytology: 98A3-98A4).
All limits from polytene analysis (FBrf0053814)