FlyBase Aberration Report: Dmel\Df(3R)Espl22

General Information

Symbol

Df(3R)Espl22

Species

D. melanogaster

Name

FlyBase ID

FBab0002569

Feature type

chromosomal_deletion

Also Known As

E(spl)^Bx22, gro^BX22, Df(3R)E(spl)^BX22, Df(3R)BX22

Computed Breakpoints include

96F10-96F11;96F11

Features within 96F10--96F11

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

E(spl)m8-HLH¹

(de Celis et al., 1991, Shepard et al., 1989)

Mutagen

X ray

(Preiss et al., 1988)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Preiss et al., 1988)

Breakpoints

[];[]

(Preiss et al., 1988)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << HLHm5 << gro << bk2

Genetic mapping information

Comments

Small deletion.

(de Celis et al., 1991)

about 14-kb deletion (4 to 17.5 kb); about 14-kb inversion (-10.5 to -7.6 and 4 kb)

Comments on Cytology

Cytologically invisible deletion.

(Preiss et al., 1988)

Left limit of break 1 from polytene analysis (citation unavailable) Right limit of break 1 from inclusion of E(spl) (FBrf0055903) Left limit of break 2 from inclusion of E(spl) (FBrf0055903) Right limit of break 2 from polytene analysis (citation unavailable)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

E(spl)m5-HLH

(Ligoxygakis et al., 1998, Fischer-Vize et al., 1992)

E(spl)m7-HLH

(Ligoxygakis et al., 1998, Fischer-Vize et al., 1992)

E(spl)m8-HLH

(Ligoxygakis et al., 1998, Jagla et al., 1997, Price et al., 1997, Fischer-Vize et al., 1992)

gro

(Ligoxygakis et al., 1998, Price et al., 1997, de Celis and Ruiz-Gomez, 1995, Fischer-Vize et al., 1992)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

yeti-MBT

(Riede, 1996)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

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Related Comments

Phenotypic Data

In combination with other aberrations

Inferred to overlap with: Df(3R)boss15.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)Espl-P11.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)R20.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)R27.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)R70.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)R75.

(Wurmbach and Preiss, 2014)

Inferred to overlap with: Df(3R)X13.

(Wurmbach and Preiss, 2014)

Eggs from Df(3R)Espl22/Df(3L)10^H mothers exhibit an embryonic lethality significantly higher than from either Df(3L)10^H/+ or Df(3R)Espl22/+ mothers. 50-60% had no cuticle. Cuticles from 5-10% of unhatched embryos show a duplication of the posterior spiracle accompanied by disorganised denticle belts.

(Chen et al., 1999)

NOT in combination with other aberrations

56% of heterozygous flies show duplication of the anterior postalar bristle.

(Kaspar et al., 2008)

The Df(3R)Espl22 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Homozygous clones in the eye disc show a neurogenic phenotype.

(Ligoxygakis et al., 1998)

Phenotype manifest in: embryonic/larval dorsal vessel | precursor Homozygous embryos have an increased number of cardiac precursor cells.

(Jagla et al., 1997)

Df(3R)Espl22 single mutant and Df(3R)Espl22, osa³⁰⁸ double mutant clones in the eye show excess neuronal differentiation.

(Treisman et al., 1997)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Clones induced in the first larval instar generate single large patches that lack sensory bristles (macrochaetaes and microchaetes) in the notum. Clones induced in the late second or early third larval instar generate many small patches that lack sensory bristles in the notum. These areas correspond to areas of neural hyperplasia in the developing notum. Clones in the developing wing generate extra vein material. Clones in the developing eye cause the eye to be rough and scarred with highly disorganised ommatidia.

(Tata and Hartley, 1995)

In clones in the wing, the phenotype depends on where the clone lies. In the anterior compartment all clones abutting the wing margin cause local overgrowth and pattern duplications. Those abutting the wing margin and restricted to dorsal or ventral surfaces cause overgrowth of both dorsal and ventral cells. Clones at the wing margin cause loss of sensory organs and mild scalloping of the margin. Clones double mutant for sgg^M11 and Df(3R)Espl22 in the anterior wing differentiate anterior bristles (as for clones of sgg^M11 single mutants), however double mutant clones in the posterior compartment differentiate hairs typical of the posterior wing margin.

(de Celis and Ruiz-Gomez, 1995)

The number of exit and dorsal roof glia in mutant embryos is higher than in wild-type embryos.

(Nelson and Laughon, 1994)

Embryos exhibit fused muscles in patterned arrangements, particularly in the more dorsal regions of the embryo. The birefringent is clearly correlated with the expansion of the CNS and PNS, and the loss of epidermis and the degree to which myoblast fusion occurs. Where myoblast fusion fails conspicuous clusters of mesodermal cells are formed and if epidermal territories are expanded cells in these clusters may be recruited to fusion.

(Bate et al., 1993)

Homozygotes display a wide dorsal shield that spans the width of the embryo with well formed telson and Filzkorper. One copy of P{ry⁺,HLHm5⁺,m6⁺,mX⁺,HLHm7⁺,E(spl⁺,gro⁺=E25R} is sufficient to rescue Df(3R)Espl22 to adulthood. Df(3R)Espl22/Df(3R)boss15 heterzygotes could be rescued to adulthood by the presence of the P{ry⁺,HLHm5⁺,m6⁺,mX⁺,HLHm7⁺=Ep} construct.

(Delidakis et al., 1991)

Strong to full phenotypic reversion: 250--450 facets per eye. Viable when heterozygous with a Dl allele.

(Shepard et al., 1989)

Intermediate neurogenic phenotype. P element construct carrying a wild type E(spl) gene copy partially rescues the neurogenic phenotype: less severe neural hyperplasia.

(Preiss et al., 1988)

Stocks (2)

Bloomington

3345

Df(3R)Espl22, tx¹/TM6B, Tb¹

Kyoto

106993

Df(3R)Espl22, tx¹/TM6B, Tb¹

Notes on Origin

Discoverer

Muskavitch.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Deletion of 14kb removing gro, HLHm5, HLHm7 and E(spl).

(Tata and Hartley, 1995)

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

Df (3R)Espl22

(Bonds et al., 2007)

Df(2R)E(spl)BX22

(Price et al., 1997)

Df(3R)^BX22

(Kahali et al., 2009)

Df(3R)BX22

(Wurmbach and Preiss, 2014, Johannes and Preiss, 2002, Jimenez et al., 1997, Riede, 1996)

Df(3R)E(spl)^BX22

(Goldstein et al., 1999, Ligoxygakis et al., 1998, de Celis and Ruiz-Gomez, 1995, Paroush et al., 1994, Kooh et al., 1993, Shepard et al., 1989)

Df(3R)E(spl)^Bx22

(Jagla et al., 1998, Jagla et al., 1997)

Df(3R)E(spl)BX22

Df(3R)Espl22

(Bivik et al., 2016, Bejarano et al., 2007, Chao et al., 2007, Wehn and Campbell, 2006)

Df(3R)Espl²²

(Venken, 2006)

E(spl)^BX22

(Nagel and Preiss, 1999, Huang and Fischer-Vize, 1996, Verheyen et al., 1996, Tata and Hartley, 1995, Jennings et al., 1994, Nelson and Laughon, 1994, Bate et al., 1993, Coyle-Thompson and Banerjee, 1993, Abmayr et al., 1992, Fischer-Vize et al., 1992, Corbin et al., 1991, de Celis et al., 1991, Delidakis et al., 1991, Xu and Artavanis-Tsakonas, 1990, Shepard et al., 1989, Preiss et al., 1988)

E(spl)^Bx22

(Wheeler et al., 2002)

E(spl)^Drvbx22

(Long et al., 1996)

E(spl)^r16

E(spl)BX22

(Aronson et al., 1997)

Gro^BX22

(Walrad et al., 2010)

gro^BX22

(Helman et al., 2011, Walrad et al., 2011, Cinnamon et al., 2008, Chao et al., 2007, Liotta et al., 2007, Hasson et al., 2005, Cinnamon et al., 2004, Atchison et al., 2003, Kobayashi et al., 2001, Chen et al., 1999, Cavallo et al., 1998, Dubnicoff et al., 1997, Paroush et al., 1997)

groBX22

(Kaspar et al., 2008)

Name Synonyms

Secondary FlyBase IDs

FBal0003337

References (57)

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