FlyBase Aberration Report: Dmel\Df(3R)e-BS2

General Information

Symbol

Df(3R)e-BS2

Species

D. melanogaster

Name

Deficiency (3R) ebony

FlyBase ID

FBab0002769

Feature type

chromosomal_deletion

Also Known As

Df(3R)eBS2, Df(3R)e^BS2, Df(3R)eB52

Computed Breakpoints include

93C3;93F14

Features within 93C3--93F14

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

gamma ray

(Newby and Jackson, 1991)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Baehrecke, 1997, Lo and Frasch, 1997, Price et al., 1997, Duffy et al., 1996, Pauli et al., 1995, Gorczyca et al., 1994, Matthews, 1994.5.31, Newby and Jackson, 1991)

Breakpoints

93C3;93F

(Duffy et al., 1996, Pauli et al., 1995, Gorczyca et al., 1994, Newby and Jackson, 1991)

93C3-93C6;93F14-94A1

(Lo and Frasch, 1997, Price et al., 1997, Matthews, 1994.5.31)

93B;93F14

(Baehrecke, 1997)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << l(3)93Dm << E(Egfr)C22 << bk2 << sar1

Genetic mapping information

Comments

Comments on Cytology

Cytology based on in situ hybridization

(Matthews, 1994.5.31)

Limits of break 1 from polytene analysis (FBrf0054506) Left limit of break 2 from polytene analysis (FBrf0075280) Right limit of break 2 from polytene analysis (FBrf0093061)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

bap

(Jagla et al., 1997)

Burs

(Dewey et al., 2004)

C15

(Campbell, 2005)

E2f1

(Royzman et al., 2002, Spradling et al., 1999, Royzman et al., 1997, BDGP Project Members, 1994-1999)

E(Egfr)C22

(Price et al., 1997)

Eip93F

(Chen et al., 1996)

glec

(Sharrow and Tiemeyer, 2001)

how

(Lo and Frasch, 1997, Zaffran et al., 1997)

InR

(Spradling et al., 1999, Jagla et al., 1997, Chen et al., 1996, BDGP Project Members, 1994-1999)

l(3)93DFa

(Chen et al., 1996)

l(3)93DFb

(Chen et al., 1996)

l(3)93DFc

(Chen et al., 1996)

l(3)93DFd

(Chen et al., 1996)

l(3)93DFe

(Chen et al., 1996)

l(3)93DFf

(Chen et al., 1996)

l(3)93DFg

(Chen et al., 1996)

l(3)93DFh

(Chen et al., 1996)

l(3)93DFi

(Chen et al., 1996)

l(3)93Dk

(Chen et al., 1996)

l(3)93Dl

(Chen et al., 1996)

l(3)93Dm

(Chen et al., 1996)

l(3)ry6

(Chen et al., 1996)

lbe

(Jagla et al., 1997)

lbl

(Jagla et al., 1997)

mod(mdg4)

(Gorczyca et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

pit

(Zaffran et al., 1998)

slou

(Jagla et al., 1997)

tin

(Jagla et al., 1997, Gorczyca et al., 1994, Bodmer, 1993, Reuter et al., 1993)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

lncRNA:Hsrω

(BDGP Project Members, 1994-1999)

lqfR

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Rab11

(Jankovics et al., 2001)

Sar1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

Homozygous embryos show defects in commissure formation. The commissures are tightly fasciculated into a single bundle in late stage 12 and early stage 13 embryos and remain poorly separated into mid-stage 13 (in contrast to wild-type embryos which show clear commissural separation by mid-stage 13). Partial commissural fusions and distortions remain common in late stage 13 and early stage 14 homozygous embryos. The commissural axons form a dense bundle at the dorsal boundary of the nerve cord in homozygotes (in contrast to wild type where they interdigitate amongst the midline glia). The commissural bundles are thicker and the longitudinal fibres are sparser than normal. The pCC axon does not extend as far anteriorly in homozygous embryos as in wild type at stage 12/1, and appears stalled after minimal outgrowth. The pCC axon frequently remains stalled at early stage 13, although many late stage 13 embryos show nearly normal extension of the pCC axon into the next anterior segment. 95% of embryos show delayed longitudinal growth in, on average, more than 50% of their segments. Additional morphological defects are seen by mid to late stage 14 in homozygous embryos. The formation of midgut constrictions is blocked, resulting in a large, poorly organised gut. The midgut mass displaces and fragments the nerve cord, particularly in upper abdominal segments, resulting in both commissural and longitudinal discontinuities in the nerve cord.

(Sharrow and Tiemeyer, 2001)

Homozygous embryos die before hatching.

(Chen et al., 1996)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (2)

Bloomington

3013

Df(3R)e-BS2, rsd¹/TM3, Sb¹

Kyoto

106782

Df(3R)e-BS2, rsd¹/TM3, Sb¹

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

Df(3R)e-B52

(Lindsley and Zimm, 1992)

Df(3R)e-BS2

(Sun et al., 2024, Baumgardt et al., 2014)

Df(3R)e^-BS2

(Sharrow and Tiemeyer, 2001)

Df(3R)e^BS2

(Lee et al., 2000, Baehrecke, 1997, Chen et al., 1996, Reuter et al., 1993)

Df(3R)eB52

(Gorczyca et al., 1999, Gorczyca et al., 1994)

Df(3R)eBS2

(Jagla et al., 1997, Pauli et al., 1995, Bodmer, 1993, Newby and Jackson, 1991, Bodmer et al., 1990)

Df(E2F1)^(3R)e-BS2

(Khurana et al., 2006)

E2f^Df3013

(Baumgardt et al., 2014)

Δ3013

(Sharrow and Tiemeyer, 2001)

Name Synonyms

Deficiency (3R) ebony

Secondary FlyBase IDs

References (35)

Report Sections

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