bk1 << N << bk2
When males with Dp(1;1)Co are crossed with T(1;2)scS2 females, and somatic clones are induced (in the wing disc) with a FRT site at 18A, clones with cells containing 4 copies of dm (2 endogenous and 2 from the tandem duplication in Dp(1;1)Co) and heterozygous for RpL19 (due to missing one copy of RpL19 on Ts(1Lt;2Lt)scS2). These clones are unable to out-compete surrounding cells and are eliminated.
Single cells from Dp(1;1)Co/Dp(1;1)Co ; Dp(1;2)51b/Dp(1;2)51b embryos transplanted into the ventral neurogenic region of wild-type host embryos give rise to a reduced proportion of neural cells compared to wild-type controls.
When somatic clones are made in the wing disc that are homozygous for Dp(1;1)Co (thus 4 copies of dm - 4xdmyc, two endogenous and two on the duplication) in a wild-type background, out-compete sibling clones with just the two wild-type copies of dm, and are several times larger. When similar clones are made in the adult, the 4xdmyc clones are also several times larger than the surrounding wild-type tissue. When 4xdmyc and 2xdmyc clones are made in wing discs that express pucUAS.cMa or BacA\p35UAS.cHa (driven by Scer\GAL4hh-Gal4) in the posterior compartment, 2xdmyc clones grow significantly more slowly than 4xdmyc clones in the Anterior (control) compartment. This effect is lessened in the posterior compartment. The 4xdmyc clones also grow less well in the posterior compartment.
Gottschewski, March 1934.