w << bk1 << rst << CR << bk2 << bb
In In(1)rst3/Y animals, rearrangement of adherens junctions between inter-ommatidial precursor cells from 18-31 hours APF is partially disrupted, as is arrangement of these cells into an orderly array. In the resulting adult eyes, the regular packing of ommatidia is disrupted, as is the placement of interommatidial bristles. This phenotype is partially suppressed by shgR69/+ or Mad12/+, and almost completely suppressed by tkv8/+.
Variegated rough eye.
Mutants have a mild rough eye phenotype at 22oC.
Post death stage homozygous In(1)rst3 pupal retinae have an increased average density of secondary/tertiary pigment cells compared to wild-type. Unlike wild-type, the local density of these cells is variable.
Mutant flies have a mildly altered pattern of ommatidia in the eye compared to wild type, with an occasional "jog" in the ommatidial rows.
Ectopic interommatidial bristles are seen in post-death stage In(1)rst3 pupal retinas. Adult eyes show occasional "jogs" in the ommatidial rows. These phenotypes are due to position effect variegation of rst.
Variegation for the rst phenotype causing patches of rough irregular facets in the eyes. z1 In(1)rst3 and zv77h In(1)rst3 combinations exhibit more extreme variegation for rst than seen in z+ In(1)rst3 combination. z1 In(1)rst3 females have z eye colour. zv77h In(1)rst3 males and homozygous females have red eye colour. zv77h In(1)rst3/z1 In(1)rst3 females are z.
No defects in optic chiasm.
Males and homozygous females are viable and fertile.
Eyes rough; more extreme in male than female. Less extreme than other rst alleles. Extent of mutant eye tissue decreased by Su(var) (Spofford, 1969); in X0 male variegates for w (Gersh, 1963, D. I. S. 37: 81). Precise reinversions of In(1)rst3 accompanied by reversion of phenotype reported to occur spontaneously (Gruneberg, 1935) and after X irradiation of oocytes (Novitski, 1961, Genetics 46: 711-17) but not after irradiation of sperm (Kaufmann, 1942).
Gruneberg, 16th Dec. 1933.