FB2026_03 , released September 17, 2026
Aberration: Dmel\In(3LR)TM3
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General Information
Symbol
In(3LR)TM3
Species
D. melanogaster
Name
FlyBase ID
FBab0005463
Feature type
chromosomal_inversion
Computed Cytological Breakpoints (relative to progenitor)

71C;76C;79E;93A;94D-94F;100C

Sequenced Breakpoints (relative to progenitor)
3L:15,150,269..15,150,269 (In(3LR)TM3:bk1)
(Miller et al., 2016)
3L:6,926,125..6,926,125 (In(3LR)TM3:bk10)
(Miller et al., 2016)
3R:9,943,831..9,943,831 (In(3LR)TM3:bk11)
(Miller et al., 2016)
3R:9,944,040..9,944,040 (In(3LR)TM3:bk12)
(Miller et al., 2016)
3R:23,050,763..23,050,763 (In(3LR)TM3:bk2)
(Miller et al., 2016)
3L:19,386,273..19,386,273 (In(3LR)TM3:bk3)
(Miller et al., 2016)
3L:19,388,151..19,388,151 (In(3LR)TM3:bk4)
(Miller et al., 2016)
3R:20,637,930..20,637,930 (In(3LR)TM3:bk5)
(Miller et al., 2016)
3L:22,637,876..22,637,876 (In(3LR)TM3:bk6)
(Miller et al., 2016)
3L:22,637,952..22,637,952 (In(3LR)TM3:bk7)
(Miller et al., 2016)
3L:22,637,952..22,637,952 (In(3LR)TM3:bk7)
(Miller et al., 2016)
3R:31,653,695..31,653,695 (In(3LR)TM3:bk8)
(Miller et al., 2016)
3R:31,653,695..31,653,695 (In(3LR)TM3:bk8)
(Miller et al., 2016)
3L:6,925,034..6,925,034 (In(3LR)TM3:bk9)
(Miller et al., 2016)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order

3Lt - 65E | 85E - 79E | 100C - 100F2 | 92D1 - 85E | 65E - 71C | 94D - 93A | 76C - 71C | 94F - 100C | 79E - 76C | 93A - 92E1 | 100F3 - 3Rt

Progenitor
T(1;3)sc260-20
In(3R)C
In(3LR)sep
In(3LR)TM3-3
(Miller et al., 2016)
In(3LR)TM3-2
(Miller et al., 2016)
In(3LR)TM3-1
(Miller et al., 2016)
Mutagen
X ray
(Lewis, 1960)
Class of aberration (relative to wild type)
chromosomal_inversion
Class of aberration (relative to progenitor)
Cytological Breakpoints (relative to progenitor)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

One of two 3L breakpoints of In(3LR)sep.

(Miller et al., 2016)

One of two 3L breakpoints of In(3LR)TM3b.

(Miller et al., 2016)

One of two 3L breakpoints of In(3LR)TM3c.

(Miller et al., 2016)

One of two 3R breakpoints of In(3LR)sep.

(Miller et al., 2016)

The 3L breakpoint of In(3LR)TM3a.

(Miller et al., 2016)

The 3R breakpoint of In(3LR)TM3a.

(Miller et al., 2016)

The 3R breakpoint of In(3LR)TM3b.

(Miller et al., 2016)

The 3R breakpoint of In(3LR)TM3c.

(Miller et al., 2016)
Comments on Cytology

All limits from polytene analysis (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations
    Stocks (0)
    Notes on Origin
    Discoverer

    E.B. Lewis, July 1955.

     

    Multiple rounds of X-raying were used to add three inversions, 71C;94D-F, 76C;93A, and 79E;100C to a chromosome already carrying two inversions, In(3LR)sep (65D2-3;85F2-4) and In(3R)C (92D1-E1;100F2-3) (FBrf0013161, FBrf0232806). The original TM3 also carried a small translocation that replaced the tip of 3L with the tip of X, including the wildtype y gene (FBrf0013161). However, most TM3 chromosomes today carry a normal 3L tip due to crossovers between TM3 and non-balancer chromosomes (FBrf0232806). Note that the 94D breakpoint disrupts p53 (FBrf0232806, FBrf0247151).

    (Parks and Cook, 2026.8.6)
    Balancer / Genotype Variants of the Aberration
     
    TM3
    (Miller et al., 2020, Ghavi-Helm et al., 2019, Miller et al., 2019, Miller et al., 2016, Joyce and McKim, 2010, FlyBase Curators, 2006-, Seppo et al., 2003, Bloomington Drosophila Stock Center, 1998.5.16, Cook et al., 1997, Lindsley and Zimm, 1992)
    TM3-2xTb-RFP
    (Pina and Pignoni, 2012)
    TM3-4
    (FlyBase Curators, 2006-)
    TM3-5
    (FlyBase Curators, 2006-)
    TM3,daeh
    (Mohler et al., 1992)
    TM3-ArSS
    (FlyBase Curators, 2006-)
    TM3-AS
    (FlyBase Curators, 2006-)
    TM3-Au1
    (FlyBase Curators, 2006-)
    TM3-ca
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1999.8.10)
    TM3-DZ
    (Rendic et al., 2010, FlyBase Curators, 2006-)
    TM3-FS10
    (Sun et al., 2012)
    TM3-FS11
    (Sun et al., 2012)
    TM3-FS18
    (Sun et al., 2012)
    TM3-FS18-GMR-GFP
    (Sun et al., 2012)
    TM3-ftz-lacZ
    (FlyBase Curators, 2006-)
    TM3-GFP
    (FlyBase Curators, 2006-)
    TM3-GMRargos
    (FlyBase Curators, 2006-)
    TM3-GTY
    (FlyBase Curators, 2006-)
    TM3-Harvester
    (Aguilar et al., 2024)
    TM3-HBL1.1
    (FlyBase Curators, 2006-)
    TM3-HoP3B
    (FlyBase Curators, 2006-)
    TM3-HShid
    (FlyBase Curators, 2006-)
    TM3-ISPSAS
    (FlyBase Curators, 2006-)
    TM3-KDN
    (Therrien et al., 2000)
    TM3-krS
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
    TM3-lacZ-hg
    (FlyBase Curators, 2006-)
    TM3-mwh2-ru1
    (FlyBase Curators, 2006-)
    TM3-P{35UZ}2
    (FlyBase Curators, 2006-)
    TM3-P{Dfd-GMR-nvYFP}3
    (Beitel, 2007.4.20)
    TM3-P{ey-FLP.B}3.1
    (FlyBase Curators, 2006-)
    TM3-P{ftz-lacC}SC1
    (FlyBase Curators, 2006-)
    TM3-P{ftz-lacZ.ry+}TM3
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
    TM3-P{ftz-lacZ}
    (FlyBase Curators, 2006-)
    TM3-P{GAL4-Hsp70.PB}TR2,P{UAS-GFP.Y}TR2
    (FlyBase Curators, 2006-)
    TM3-P{GMR-sina.N}3
    (Richardson, 2010.5.17)
    TM3-P{sE-raftorY9}3
    (Mitchell, 2007.4)
    TM3-P{sevRas1.V12}FK2
    (FlyBase Curators, 2006-)
    TM3-P{tubP-GAL80}3
    (Ghabrial, 2015.10.12)
    TM3-P{UAS-Dl.DN}
    (FlyBase Curators, 2006-)
    TM3-P{UAS-Dl.DN}TJ1
    (FlyBase Curators, 2006-)
    TM3-P{UAS-y.C}MC2
    (FlyBase Curators, 2006-)
    TM3-P{Δ2-3}
    (FlyBase Curators, 2006-)
    TM3-p+Sb1
    (FlyBase Curators, 2006-)
    TM3-pAct-GFP
    (FlyBase Curators, 2006-)
    TM3-Pw+-lacZ
    (FlyBase Curators, 2006-)
    TM3-rrSS
    (FlyBase Curators, 2006-)
    TM3-rS
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
    TM3-rSS
    (Zheng et al., 2011, FlyBase Curators, 2006-)
    TM3-rsuS
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
    TM3-ry
    (FlyBase Curators, 2006-)
    TM3-Sb
    (Kanellopoulos et al., 2012, FlyBase Curators, 2006-)
    TM3-Sb1-P{sChFP}3
    (Abreu-Blanco et al., 2012, Parkhurst, 2011.4.14)
    TM3-Sb-P{UAS-Delta.Nde.Myc}3
    (Parks and Muskavitch, 2009.3.2)
    TM3-SbSer
    (FlyBase Curators, 2006-)
    TM3-SC143
    (FlyBase Curators, 2006-)
    TM3-Ser
    (FlyBase Curators, 2006-)
    TM3-Ser-P{Dfd-GMR-nvYFP}5
    (Glashauser et al., 2023)
    TM3-Sr
    (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
    TM3-St
    (FlyBase Curators, 2006-)
    TM3-st24
    (FlyBase Curators, 2006-)
    TM3-st34
    (Adler, 2010.9.8)
    TM3-STY
    (FlyBase Curators, 2006-)
    TM3-T2B
    (FlyBase Curators, 2006-)
    TM3-TCAG
    (FlyBase Curators, 2006-)
    TM3-TCAGB
    (FlyBase Curators, 2006-)
    TM3-Thb8
    (FlyBase Curators, 2006-)
    TM3-TTG
    (FlyBase Curators, 2006-)
    TM3-UbxD105.17
    (FlyBase Curators, 2006-)
    TM3-vCa
    (FlyBase Curators, 2006-)
    TM3-vCb
    (FlyBase Curators, 2006-)
    TM3-vCd
    (FlyBase Curators, 2006-)
    TM3-vCe
    (FlyBase Curators, 2006-)
    TM3-vGa
    (FlyBase Curators, 2006-)
    TM3-vKa
    (FlyBase Curators, 2006-)
    TM3-vKb
    (FlyBase Curators, 2006-)
    TM3-vKc
    (FlyBase Curators, 2006-)
    TM3-vKd
    (FlyBase Curators, 2006-)
    TM3-vMa
    (FlyBase Curators, 2006-)
    TM3-vMb
    (FlyBase Curators, 2006-)
    TM3-vMc
    (FlyBase Curators, 2006-)
    TM3-vMd
    (FlyBase Curators, 2006-)
    TM3-vMe
    (FlyBase Curators, 2006-)
    TM3-vSa
    (FlyBase Curators, 2006-)
    TM3-vSb
    (FlyBase Curators, 2006-)
    TM3-vSc
    (FlyBase Curators, 2006-)
    TM3-vSd
    (FlyBase Curators, 2006-)
    TM3-vTa
    (FlyBase Curators, 2006-)
    TM3βT8
    (FlyBase Curators, 2006-)
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    In(3LR)TM3
    TM3
    (Parks and Cook, 2026.8.6)
    Name Synonyms
    Secondary FlyBase IDs
    • FBab0024659
    References (141)