FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Aberration: Dmel\In(3R)C
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General Information
Symbol
In(3R)C
Species
D. melanogaster
Name
Inversion (3R) Crossover suppressor
FlyBase ID
FBab0005550
Feature type
chromosomal_inversion
Computed Breakpoints include

92D1-92D9;100F2-100F3

Sequence coordinates
3R:20,308,209..20,308,209 (In(3R)C:bk1)
(Miller et al., 2020)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
natural population
(Inoue and Igarashi, 1994, Inoue et al., 1994, Das and Singh, 1991, Choi et al., 1984, Ashburner and Lemeunier, 1976, Stalker, 1976, Zacharopoulou, 1974)
spontaneous
Class of aberration (relative to wild type)
chromosomal_inversion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_inversion
(Koryakov et al., 1994, Zabalou et al., 1994, Lindsley and Hardy, 1992, Das and Singh, 1991, Taberner and Gonzalez, 1991, Choi et al., 1984, Knibb et al., 1981, Inoue and Watanabe, 1979, Ashburner and Lemeunier, 1976, Stalker, 1976, Zacharopoulou, 1974)
Breakpoints

92D;100F

(Koryakov et al., 1994, Zabalou et al., 1994, Das and Singh, 1991, Taberner and Gonzalez, 1991, Choi et al., 1984, Zacharopoulou, 1974)

92E;100F

(Stalker, 1976)

92D1-92E1;100F2-100F3

(Lindsley and Hardy, 1992, Ashburner and Lemeunier, 1976)

92D;100F2-100F3

(Inoue and Watanabe, 1979)

92D;100C

(Knibb et al., 1981)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << tll << bk2

Genetic mapping information
Comments

Distal breakpoint is at the junction of subtelomeric and telomeric sequences distal to the end of the reference genome assembly.

(Miller et al., 2020)

The 5' end of this breakpoint corresponds to 3R:20308209 and the 3' end corresponds to 3R:20308213 ; the breakpoint contains a 5bp duplication of genome sequence, in addition to the inversion.

(Miller et al., 2020)

Breakpoint(s) molecularly mapped

(Alton et al., 1989)
Comments on Cytology

Left limit of break 1 from polytene analysis (FBrf0029349) Right limit of break 1 from polytene analysis (FBrf0026036) Limits of break 2 from polytene analysis (FBrf0029349)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
tll
(Tearle and Nusslein-Volhard, 1987)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    A positive correlation between the frequency of In(3R)C in a population and the frequency of individuals carrying extra bristles has been demonstrated. The correlation has also been demonstrated at the individual level.

    (Izquierdo et al., 1991)

    Homozygous viable. Crossing over in 3R reduced to 1% between centromere and ss, to 0.2% between ss and e; no crossovers between e and tip of 3R recovered except for rare doubles within inversion.

    Stocks (41)
    Notes on Origin
    Discoverer

    Sturtevant, June 1913.

     

    One of 16 polymorphic inversions identified in the Drosophila Genetic Reference Panel (DGRP) freeze 2 lines.

    (Huang et al., 2014)

    According to Craymer in FBrf0063385, e1 was isolated on In(3R)C and was never successfully separated from it. Most ebony alleles denoted simply as "e" without a specific allele designation can be traced back to Muller's e4. Most ebony mutations in Stock Center stocks designated as e1 are probably e4.

    (Kennison and Cook, 2008.11.20)

    e1 arose on In(3R)C and has never been separated from the inversion.

    (Craymer, 1980)

    Recovered as: Cosmopolitan inversion.

    (Stalker, 1976)

    Isolation: Koleika, Greece.

    (Zacharopoulou, 1974)
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Rare cosmopolitan inversion.

    (Inoue and Igarashi, 1994, Das and Singh, 1991)

    Naturally occurring inversions have been categorised into classes according to their geographical distribution and frequencies, In(3R)C belongs to the rare Cosmopolitan class.

    (Inoue et al., 1994)

    Distribution in Indian populations studied.

    (Das and Singh, 1991)

    Rare cosmopolitan inversion. The distribution of this inversion in two populations from Valencia, Spain (one from a cellar and one from a vineyard) has been studied.

    (Taberner and Gonzalez, 1991)

    Cosmopolitan inversion.

    (Villar et al., 1991)

    Rare cosmopolitan inversion (based on Australasian frequencies of distribution).

    (Knibb et al., 1981)

    First inversion demonstrated genetically (Sturtevant, 1926). Used as a balancer for the region from Dl to 3R tip. Balancers contain Sb, e, l(3)a, or l(3)e. Balancer for all of chromosome 3 made by combining with In(3L)P. Found in wild populations (e.g., Oshima and Watanabe, 1965, D. I. S. 40: 88; Ashburner and Lemeunier, 1976, Proc. R. Soc. London, B 193: 137-57; Stalker, 1976, Genetics 82: 323-47; Choi, 1977, D. I. S. 52: 88; 1977, Genetica 47: 155-60).

    Synonyms and Secondary IDs (9)
    Reported As
    Symbol Synonym
    (3R)C
    (Caceres et al., 1999)
    3RC
    (Inoue et al., 1994)
    C3
    CIIIRE
    In(3R)B
    (Stalker, 1976)
    In(3R)C
    (Erickson et al., 2020, Miller et al., 2020, Miller et al., 2019, Miller et al., 2016, Kennison and Cook, 2008.11.20)
    In(3R)E
    In(3R)H
    Name Synonyms
    Inversion (3R) Crossover suppressor
    Secondary FlyBase IDs
      References (47)