FlyBase Aberration Report: Dmel\Tp(2;2)A446

General Information

Symbol

Tp(2;2)A446

Species

D. melanogaster

Name

FlyBase ID

FBab0009750

Feature type

deficient_intrachromosomal_transposition

Also Known As

Df(2L)A446

Computed Breakpoints include

35B1;35F1;36C1-36C2;49B1-49B3

Features within 35B1--35F1

Sequence coordinates

2L:14,492,811..14,496,471 [+] (Tp(2;2)A446:bk1)

(Chia et al., 1985)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

2Lt - 35B1 | 36C2 - 49B1 | 35F2 - 36C1 | 49B3 - 2Rt

(Roote et al., 1996)

Progenitor

Mutagen

X ray

(Fossett et al., 1994)

Class of aberration (relative to wild type)

deficient_intrachromosomal_transposition

Class of aberration (relative to progenitor)

Breakpoints

35B1;35E1--35E2;[];[]

(Ashburner et al., 1983, Ashburner et al., 1982)

35B1;35E1-35E2

(Gubb et al., 1985)

35B1-35B3;35F1;36C1-36C2;49B1-49B3

(Chia et al., 1985)

35B1-35B2;35E1-35E2

(Gubb et al., 1986)

35B1--3;35F1--2;[];[]

(Gubb et al., 1990)

35B1-35B2;35F1-35F2;36C1-36C2;49B1-49B3

(Roote et al., 1996)

Causes alleles

noc^A446

(Cheah et al., 1994)

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << noc << mol << bk2 << twe

Genetic mapping information

Comments

Lesion within noc.

(Cheah et al., 1994)

Comments on Cytology

35B1-35B3;35E6-35F2

(Pauli et al., 1995)

35B1-35B2;35E6;35F1-35F2;36C1-36C2;49B1-49B3 2Lt - 35B1 | 35E6 - 35F1 | 36C2 - 49B3 | (35F2 - 36C1) | 49B3 - 2Rt

(Ashburner et al., 1990)

35B1-35B3;35E6-35F2;^</up>;<up>

(Schupbach and Wieschaus, 1989)

Other breakpoints not reported.

(Ashburner et al., 1983, Ashburner et al., 1982)

Limits of break 1 from polytene analysis (FBrf0038047) Limits of break 2 from polytene analysis (FBrf0043115) Limits of break 3 from polytene analysis (FBrf0043115) Limits of break 4 from polytene analysis (FBrf0043115) Four-break event separable into a deficient and a duplicated component.

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Adh

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Ankrd49

(Ashburner et al., 1982)

beat-Ia

BicC

(Schupbach and Wieschaus, 1991)

Ca-α1D

(Roote et al., 1996, Fossett et al., 1994)

CIAPIN1

(Ashburner et al., 1982, Ashburner et al., 1982)

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Cul3

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

CycE

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

DCTN5-p25

(Ashburner et al., 1982)

esg

(Fossett et al., 1994)

halo

(Welte et al., 2005)

l(2)35De

(Fossett et al., 1994)

lace

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

mol

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

noc

(Davis et al., 1997, Roote et al., 1996, Cheah et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

osp

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

PolD3

(Ashburner et al., 1982, Ashburner et al., 1982)

Rnmt

(Ashburner et al., 1982)

sna

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

stc

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Su(H)

(Ashburner et al., 1982)

TfIIS

(Fossett et al., 1994)

Thg

(Ashburner et al., 1982)

Uxt

(Fossett et al., 1994)

vas

(Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

wek

(Fossett et al., 1994)

wor

(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

Partially deleted / disrupted

noc

(Fossett et al., 1994)

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Adc

(Ashburner et al., 1982)

Arpc1

(Ashburner et al., 1982)

elA

(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

elB

(Davis et al., 1997, Roote et al., 1996, Fossett et al., 1994)

kuz

(Fossett et al., 1994)

l(2)34Db

(Fossett et al., 1994, Ashburner et al., 1982)

l(2)34Fc

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

l(2)34Fd

(Roote et al., 1996, Ashburner et al., 1982)

mRpL4

(Fossett et al., 1994)

ms(2)34Fe

(Roote et al., 1996)

NimA

(Ashburner et al., 1982)

NimC3

(Fossett et al., 1994, Ashburner et al., 1982)

Pburs

(Davis et al., 1997, Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982)

Pgant35A

(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)

PolG1

(Ashburner et al., 1982)

PolG2

(Ashburner et al., 1982)

Polr2C

(Fossett et al., 1994, Ashburner et al., 1982)

Smg5

(Fossett et al., 1994, Ashburner et al., 1982)

Sos

(Ashburner et al., 1982)

(Fossett et al., 1994, Ashburner et al., 1982)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
In these cases, there will be no "Export to Hitlist" button to the left.

Related Comments

Tp(2;2)A446 complements mutations in the l(2)35Ba region of noc but does not complement the nocA region of noc.

(Fossett et al., 1994)

Phenotypic Data

In combination with other aberrations

The net plus-end (phase II) transport of lipid droplets along microtubules is disrupted in Df(2L)dp-79b/Tp(2;2)A446 embryos, resulting in the apical accumulation of droplets in the embryo.

(Welte et al., 2005)

NOT in combination with other aberrations

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Chromosome has no effect on the physical interaction between tandemly duplicated copies of w⁺ and z¹, despite having breakpoints within the critical region.

(Gubb et al., 1990)

Very weak, sterile, small fly and dominant wavy wing phenotype.

(Ashburner et al., 1982)

heterozygous semi-lethal escapers are sterile and have a wavy-wing and small-fly phenotype.

Stocks (0)

Notes on Origin

Discoverer

Aaron.

selected as ADH null on 1-penten-3-ol.

Balancer / Genotype Variants of the Aberration

Separable Components

Df(2L)A446

Dp(2;2)A446

Other Comments

Reported to delete Adhr in error; see FBrf0141768 for correction.

(Roote et al., 1996)

Aberration has no effect on z but has breakpoints within the z critical region.

(Gubb et al., 1990)

Note that Df(2L)A446 is not an aneuploid recombinant between Tp(2;2)A446 and a wild-type sequence, but merely a synonym for Tp(2;2)A446, since Tp(2;2)A446 is deficient in region 35B-35E. A deficient recombinant which would be deleted for 35B-36C, would probably be dominant lethal.

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

A446

(Fossett et al., 1994)

Df(2L)A446

(Ashburner et al., 1999, Davis et al., 1997, Roote et al., 1996, Gubb et al., 1990, Schupbach and Wieschaus, 1989, Gubb et al., 1985)

Tp(2;2)A446

Name Synonyms

Secondary FlyBase IDs

FBab0009751

References (23)

Report Sections

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