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General Information
D. melanogaster
FlyBase ID
Also Known As
Computed Breakpoints include


Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)


Carries alleles
Transposon Insertions
Formalized genetic data

bk3 hits bw

Genetic mapping information

No accumulation of bw RNA detectable.

Comments on Cytology

Large heterochromatic insertion into the bw gene.

All limits from complementation mapping against bw (FBrf0083184)

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
Molecular Data
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    The position effect variegation at the bw locus caused by Dp(?;2)bwD is suppressed by Df(3R)Ace-HD1.

    NOT in combination with other aberrations

    In interspecific bwD heterozygotes (in which D.melanogaster bwD has been introgressed into the D.simulans background and backcrossed to D.simulans for six generations), the 59E region does not associate with the X chromosome heterochromatin, but does associate with the second chromosome heterochromatin, in interphase nuclei of larval central nervous system cells.

    Syncytial blastoderm embryos have gaps in the field of nuclei and many nuclei have fallen into the interior of the embryo. Typically, these interior nuclei are in pairs connected by a thin thread of chromatin. The frequency of these defects is 4 to 16-fold higher than in wild-type embryos.

    PEV is observed as the very strong dominant variegating effect on the bw+ copy present on the homologous chromosome. Heterozygotes with Df(2R)bw5 exhibit about 2% eye pigmentation.

    Eye color varies with age from purple to brown. Shows slight variegation in combination with st (FBrf0010216). Wings pebbled. bwD/+ shows nearly a 100-fold reduction in pteridine levels. bwD/bwV1 > bwD/+ > bwD/bwD in severity of effect (FBrf0050859). Variegation suppressed by extra Y chromosomes (FBrf0012497). Homozygote viable and fertile. Larval Malpighian tubules bright yellow (FBrf0005752).

    Stocks (52)
    Notes on Origin

    T. Hinton, 1940.

    Balancer / Genotype Variants of the Aberration
    Separable Components
    Other Comments

    Since 1950 some and perhaps all lines of Dp(?;2)bwD have undergone a secondary event that removed a portion of the coding region of the bw gene, generating a null allele (FBrf0050859).

    Synonyms and Secondary IDs (4)
    References (37)