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General Information
Symbol
Df(2R)BSC19
Species
D. melanogaster
Name
FlyBase ID
FBab0029795
Feature type
Computed Breakpoints include
Sequence coordinates
2R:20,274,486..20,274,486 (Df(2R)BSC19:bk1)
2R:20,588,392..20,588,392 (Df(2R)BSC19:bk2)
Member of large scale dataset(s)
Dfs_BSC_set1

A set of ~50 targeted deficiencies created by exploiting hybrid element insertion (HEI) and resolution; designed to fill gaps in deletion coverage.

Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

The 2R:20274486 release 6 coordinate of the left breakpoint is an estimate. It corresponds to the insertion site of P{EP}CG10444EP951. Df(2R)BSC19 was generated by expression of P transposase in the presence of trans-heterozygous P elements. Since the deletion chromosome did not retain the miniwhite marker from either progenitor P insertion, it was probably formed by nonhomologous end joining of breaks near the insertion sites of the progenitor P insertions. Df(2R)BSC19 heterozygotes do not show Minute phenotypes, so the haploinsufficient RpS18 gene lies to the left of this breakpoint.

The 2R:20588392 release 6 coordinate of the left breakpoint is an estimate. It corresponds to the insertion site of P{lacW}l(2)s4831s4831. Df(2R)BSC19 was generated by expression of P transposase in the presence of trans-heterozygous P elements. Since the deletion chromosome did not retain the miniwhite marker from either progenitor P insertion, it was probably formed by nonhomologous end joining of breaks near the insertion sites of the progenitor P insertions.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Homozygous Df(2R)BSC19 mutant embryos produce a phenotype in which only the dorsal branch of the abdominal segmental nerve (SNa) is absent or malformed. In 25% of abdominal hemisegments one or more of the dorsal branch target muscles is not present, and this could account for the absence of the branch in these hemisegments.

The Df(2R)BSC19 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

Stocks (2)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The miniwhite markers from both P{EP}CG10444EP951 and P{lacW}l(2)s4831s4831 were deleted or disrupted.

Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)