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General Information
Symbol
Df(2R)ED2247
Species
D. melanogaster
Name
FlyBase ID
FBab0033542
Feature type
Also Known As
ED2247
Computed Breakpoints include

[48A3-48A3];[48D5-48D5];

Sequence coordinates
2R:11,600,106..11,600,106 (Df(2R)ED2247:bk1)
2R:11,988,720..11,988,720 (Df(2R)ED2247:bk2)
Member of large scale dataset(s)
Dfs_DrosDel_set1

A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial core set of 209 isogenic deletions provides ~60% euchromatic genome coverage.

Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

Confirmed by 3-step PCR confirmation as shown in http://www.drosdel.org.uk/del_confirm.php Confirmed by lack of complementation to a known lethal mutation predicted to fall between the progenitor insertions.

Limits of break 1 computationally determined from location of progenitor P insertion on genome sequence between P{lacW}Tapδk17005&P{lacW}k05103 and P{lacW}l(2)k13403k13403&P{lacW}Egmk14708 Limits of break 2 computationally determined from location of progenitor P insertion on genome sequence between P{lacW}l(2)k06612k06612 and P{lacW}jebk05644

Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Df(2R)BSC879/Df(2R)ED2247 embryos do not accumulate the tracheal chitin filament and the trachea remain uninflated. A normal pattern of migration and tracheal cell specification is observed, but branches completely lack luminal and apical-cuticular chitin. General apicobasal polarity and adhesion are not affected. The dorsal trunk has a cystic appearance, with many dilations and constrictions, and the presence of apical expansions, usually at joints between branches; there are also abnormal cell shapes in the dorsal trunk.

Df(2R)BSC879/Df(2R)ED2247 embryos show a fragmented and granular head skeleton and an inflated and misshapen larval shape. The tracheal envelope and epicuticle is detached from the epithelial cells, while the space between these structures and the epithelial cells is devoid of material. The envelope and the epicuticle of the integument is decreased in thickness and the procuticle is amorph.

NOT in combination with other aberrations

Heterozygotes show hypersensitivity to halothane and enflurane compared to controls.

Stocks (2)
Notes on Origin
Discoverer
 

Potential deficiency; could be generated as the recombinant product between the reduced derivatives of P{RS5}5-HA-1812 and P{RS3}CB-0229-3.

Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (3)
References (17)