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General Information
Symbol
Df(3R)MR22
Species
D. melanogaster
Name
FlyBase ID
FBab0037763
Feature type
Sequence coordinates
3R:27,580,268..27,580,268 (Df(3R)MR22:bk1)
3R:27,652,818..27,652,818 (Df(3R)MR22:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Left-hand (5') breakpoint stated to be "position 144,091 in genomic contig AE003761", which corresponds to 27,580,268 on chromosome 3R in release 6.

Right-hand (3') breakpoint based on insertion site of P{EP}tauEP3203.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Four-week old Df(3R)BSC499/Df(3R)MR22 mutant flies exhibit retinal degeneration. The retinas and rhabdomeres are indistinguishable from wild type at 1 day after eclosion, but show a loosening of the microvilli at 7 days. No photoreceptor loss is seen. An increased number of vacuoles is seen in the brains of 28-day old flies compared to age-matched controls. The axons of 1-day old flies are similar to controls but occasionally exhibit abnormal gaps between the axons. By 16 days, many more and larger extracellular gaps are seen between the axons. There is an increase in the cross sectional area of microtubules in 1-day old Df(3R)BSC499/Df(3R)MR22 mutant flies compared to controls, as well as a reduction in the density of microtubules per neurite.

NOT in combination with other aberrations
Stocks (1)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

FlyBase curator comment: In the Results section, 'Df(3R)MR22' is described as "a 62 kb deletion extending distally from EP(3)3203 that removes almost all of the tau locus". However, data in Figure 6A and the Methods section show that the deletion actually extends proximally from the insertion site, and that the deletion is approximately 72.5kb (on release 6 genome).

Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (8)