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FB2026_01
,
released March 12, 2026
[60C4-60C4];[60C7-60C7];
A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
60C4;60C7
Breakpoint from FlyBase's release 5 sequence location of progenitor insertion.
Df(2R)BSC603/Df(2R)Exel6082 transheterozygotes are viable but show a blistered wing phenotype; the indirect flight muscles are correctly specified but there are myofibril defects (low polymerized actin content), while the jump muscles appear normal.
Homozygotes show lethality at late stages of embryogenesis. The body wall muscles develop correctly in the mutant embryos and attach to the epidermis as in wild type. The gut elongates and forms gut constrictions in the mutant embryos and the visceral muscles develop normally. Cardioblasts of the dorsal vessel and macrophages are shaped normally in the mutant embryos. At the end of embryogenesis the mutant embryos are able to move in the eggshell and can contract their muscles (although not as frequently or as vigorously as wild type), but they do not hatch.