Deletion that completely removes the polycistronic transcription unit encoding hemo and CG43210. The first non-coding exons of fray and of fru are also deleted. Generated by FLP-mediated recombination between the two progenitor insertions P{RS3}frayCB-0706-3 and PBac{WH}fruf02684.
Df(3L)BSC727/+, Df(3R)hemo-A4/Df(3R)hemo-A4 mutant hemocytes do not exhibit a significant endolysosome phenotype.
Df(3R)hemo-A4/Df(3R)hemo-A4 flies reach adulthood and do not exhibit overt morphological defects, but their hemocytes exhibit increased vacuolar morphology and increased accumulation of acidic endolysosome compartments, slower processing of E. coli bacteria, and mutants exhibit a higher bacterial load, reduced resistance to non-pathogenic E. coli, and shortened lifespan in comparison to wild-type controls.
