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General Information
Symbol
hemo-A4
Species
D. melanogaster
Name
FlyBase ID
FBab0048092
Feature type
Sequence coordinates
3R:18,533,250..18,533,250 (hemo-A4:bk1)
3R:18,573,813..18,573,813 (hemo-A4:bk2)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Class of aberration (relative to wild type)
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments

Deletion that completely removes the polycistronic transcription unit encoding hemo and CG43210. The first non-coding exons of fray and of fru are also deleted. Generated by FLP-mediated recombination between the two progenitor insertions P{RS3}frayCB-0706-3 and PBac{WH}fruf02684.

Scer\FRT-mediated recombination between the two progenitor insertions (PBac{WH}fruf02684 and P{RS3}frayCB-0706-3 has resulted in the deletion of the genomic sequence between them.

Comments on Cytology
Sequence Crossreferences
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Df(3L)BSC727/+, hemo-A4/hemo-A4 mutant hemocytes do not exhibit a significant endolysosome phenotype.

NOT in combination with other aberrations

hemo-A4/hemo-A4 flies reach adulthood and do not exhibit overt morphological defects, but their hemocytes exhibit increased vacuolar morphology and increased accumulation of acidic endolysosome compartments, slower processing of E. coli bacteria, and mutants exhibit a higher bacterial load, reduced resistance to non-pathogenic E. coli, and shortened lifespan in comparison to wild-type controls.

Stocks (0)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
hemo-A4
Name Synonyms
Secondary FlyBase IDs
    References (1)