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General Information
Symbol
Dmel\cact1
Species
D. melanogaster
Name
FlyBase ID
FBal0001507
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cact99
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

cact1/cact4 larvae do not show R2-R5 photoreceptor axon targeting defects in the developing visual system.

Mutant third instar larvae have melanotic nodules found in the hemocoel or in association with He-positive lymph glands. They also show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.

cact1/cact4 mutant embryos exhibit a strong ventralised phenotype.

Pupal lethal when heterozygous with the MBT chromosome.

Weakly ventralised embryos. When maternal or zygotic tkv levels are reduced most of the embryos die and show an increased level of ventralisation.

Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions.

Embryos from homozygous mothers appear 'ventralized'; at differentiation they form only a narrow strip of dorsal cuticle, whereas ventral setal belts are expanded and encircle in irregular fashion most of the embryonic periphery. At gastrulation the germband hardly extends at all and the posterior midgut invaginates close to the posterior pole. Cephalic furrow is more pronounced than in wildtype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
NOT Enhancer of
Statement
Reference

cact[+]/cact1 is a non-enhancer of visible | heat sensitive phenotype of peb1

NOT Suppressor of
Statement
Reference

cact[+]/cact1 is a non-suppressor of visible | heat sensitive phenotype of peb1

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
NOT Enhancer of
Statement
Reference

cact[+]/cact1 is a non-enhancer of eye | heat sensitive phenotype of peb1

NOT Suppressor of
Statement
Reference

cact[+]/cact1 is a non-suppressor of eye | heat sensitive phenotype of peb1

Other
Additional Comments
Genetic Interactions
Statement
Reference

wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 cact4/cact1 mutant embryos exhibit a strongly dorsalised phenotype identical to wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 alone.

6% of embryos derived from cype03771/+ ; cact1/+ females crossed to wild-type males die. 80% of the dead embryos are weakly ventralised (the head is not involuted, the posterior segments are internalised and the Filzkorper are disorganised) and 20% are moderately ventralised (the ventral denticle belt is extended laterally, Filzkorper are reduced and disorganised, the head is not involuted and the head and thorax are extended and convoluted).

Xenogenetic Interactions
Statement
Reference

The presence of a copy of cact1 significantly enhances the Hsap\CHMP2BIntron5.Scer\UAS Scer\GAL4GMR.PF phenotype.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (20)