FlyBase Allele Report: Dmel\csw[6]

General Information

Symbol

Dmel\csw⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0001925

Feature type

allele

Associated gene

Dmel\csw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Perkins et al., 1992)

Mutagen

ethyl methanesulfonate

(Perkins et al., 1996, Perkins et al., 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Noonan syndrome 1

CEA

(Ruzzi et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle | germline clone

(Perkins et al., 1996)

embryonic epidermis | posterior

(Ghiglione et al., 1999)

neurogenic region

(Perkins et al., 1996)

tracheal precursor cell | germline clone

(Perkins et al., 1996)

Detailed Description

Statement

Reference

The extent to which posterior pattern elements are formed directly reflects the magnitude of tor signal. Thus mutants derived from germ line clones can be ordered with respect to increasing posterior abnormalities thus: phl¹ (normal posterior patterning) - csw⁶ - csw⁶,phl¹ - csw⁵,phl^PB26 (deletion of A8).

(Ghiglione et al., 1999)

csw⁶ germline clone mosaics cause maternal effect lethality. Embryos derived from mothers with germline clones that exhibit a corkscrew cuticle phenotype (6%) have slight paternal rescue of the germline clone phenotype, embryos that do not receive a wild type copy from their father (94%), null embryos, die with a 'U'-shaped cuticle phenotype. In mutant embryos ventral cells undergo cell fate changes to that of more lateral epidermal cell fates. Migration of tracheal precursor cells is defective in embryos, the mature trachea shows disruption of the major anterioposterior tracheal branch. Pupal lethality can be rescued by heat induced expression of P{hs-SHP-2} during larval and pupal stages but not by expression of P{hs-SHP-1}.

(Perkins et al., 1996)

Abnormal development of terminal internal structures.

(Perkins et al., 1992)

csw⁶ is viable and fertile with rough eyes. fertile viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

csw⁶ has long lived phenotype, non-enhanceable by InR^E19

(Ruzzi et al., 2020)

csw⁶ has long lived phenotype, non-enhanceable by chico¹

(Ruzzi et al., 2020)

Suppressed by

Statement

Reference

csw⁶ has lethal | pupal stage phenotype, suppressible by Hsap\PTPN11^hs.PP

(Perkins et al., 1996)

NOT suppressed by

Statement

Reference

csw⁶ has long lived phenotype, non-suppressible by InR^E19

(Ruzzi et al., 2020)

csw⁶ has long lived phenotype, non-suppressible by chico¹

(Ruzzi et al., 2020)

csw⁶ has lethal | pupal stage phenotype, non-suppressible by Hsap\PTPN6^hs.PP

(Perkins et al., 1996)

Enhancer of

Statement

Reference

csw⁶ is an enhancer of visible phenotype of Egfr^DN.UAS.cBa, Scer\GAL4^T155

(Perkins et al., 1996)

NOT Enhancer of

Statement

Reference

csw⁶ is a non-enhancer of long lived phenotype of InR^E19

(Ruzzi et al., 2020)

csw⁶ is a non-enhancer of long lived phenotype of chico¹

(Ruzzi et al., 2020)

NOT Suppressor of

Statement

Reference

csw⁶ is a non-suppressor of long lived phenotype of InR^E19

(Ruzzi et al., 2020)

csw⁶ is a non-suppressor of long lived phenotype of chico¹

(Ruzzi et al., 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

csw⁶ has phenotype, suppressible by csw::Src64B^{C583S.hs.2sev}

(Allard et al., 1998)

Other

Statement

Reference

Raf¹, csw⁶ has embryonic epidermis | posterior phenotype

(Ghiglione et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^sca-C253 mediated expression of Egfr^{DN.Scer\UAS.cBa} generates flies with reduced eyes and females carrying Scer\GAL4^T155 and Egfr^{DN.Scer\UAS.cBa} lay partially to completely ventralised eggs. These phenotypes are enhanced in a csw⁶ mutant background.

(Perkins et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

csw⁶ is rescued by csw^hs.2sev

(Allard et al., 1998)

Not rescued by

csw⁶ is not rescued by csw^{G547E.hs.2sev}

(Allard et al., 1998)

csw⁶ is not rescued by csw^CS.hs.2sev

(Allard et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

23876

y¹ csw⁶ P{FRT(w^hs)}101/FM7a

Notes on Origin

Discoverer

Comments

Phenotypic series of csw mutant embryos derived from homozygous germline clones, classified according to cuticular phenotype: csw⁵ = csw^LE120 > csw¹ = csw^13-87 > csw^e13d.3 > csw⁷ = csw⁶. Weak csw allele.

(Perkins et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

csw⁶

(Popodi et al., 2010-)

l(1)15086

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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