FlyBase Allele Report: Dmel\Duox[Cy]

General Information

Symbol

Dmel\Duox^Cy

Species

D. melanogaster

Name

Curly

FlyBase ID

FBal0002196

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

GBrowse JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

2L:2,816,443..2,816,443 [-]

Nucleotide change:

G2816443T

Amino acid change:

G1505C | Duox-PB; G1505C | Duox-PC

Reported amino acid change:

G1505C

Reported_genomic_loc:

2L_r6:2816443..2816443

Comment:

The nucleotide change is correct and the amino acid change is reversed between Duox[Cy] and Duox[K] in Figure 1B.

(Hurd et al., 2015)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

(Amino acid change is revision of data in FBrf0230212).

(Erdi, 2020.4.4)

Amino acid replacement: G1505C.

(Erdi, 2020.4.4, Miller et al., 2018)

Nucleotide substitution: C?A.

(Miller et al., 2018)

Carried on aberration

CyO-Df(2L)noc20

CyO-Df(2R)cn-S3

CyO-Df(2R)cn-S6

CyO-Dp(2;2)M(2)m⁺

CyO-Hsp70-PBac\T.w⁺

CyO-Hsp70-PBac\T.w^-

CyO-numb^k09918

CyO-P{dam⁺.phy705}11

CyO-P{dam⁺.phy705}12

CyO-P{dam⁺.phy705}34

CyO-P{Dfd-EYFP.w^BmC}2

CyO-P{Dfd-EYFP}2

CyO-P{en1}wg^en11

CyO-P{ftz/lacC}USC1

CyO-P{ftz-lacZ.w⁺}

CyO-P{GAL4-Hsp70.PB.w^mC.mut}MP

CyO-P{GMR-p21.Ex}2

CyO-P{hsH\T-2}1

CyO-P{hsH\T-2}2

CyO-P{ovoD1-18}131

CyO-P{sE-raf^torY9}475

CyO-P{SUPor-P}RR1

CyO-PBac{Delta2-3.Exel}2

CyO-pk^pk-sple-46

CyO-pk^pk-sple-47

CyO-pk^pk-sple-48

CyO-pk^pk-sple-49

CyO-Tub-PBac\T.w⁺

CyO-Tub-PBac\T.w^-

SM6a-P{RS3}CB-0100-3

SM6a-P{RS3}CB-0102-3

SM6a-P{RS5}5-HA-1005

SM6a-P{RS5}5-HA-1006

SM6a-P{RS5}5-HA-1007

SM6a-P{RS5}5-HA-1018

SM6a-P{RS5}5-HA-1023

SM6a-P{RS5}5-HA-1026

T(2;3)SM6b-TM6B

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Duox^K)

(Hurd et al., 2015)

lethal (with Duox^KG07745)

(Hurd et al., 2015)

lethal | recessive

(Hurd et al., 2015)

Phenotype Manifest In

(Zimm and Lindsley, 1996.1.25)

Detailed Description

Statement

Reference

Cy¹ is dominant in D.melanogaster/D.simulans hybrids.

(Goldschmidt, 1999)

Wing phenotype is additive with that of U¹ and U².

(Zimm and Lindsley, 1996.1.25)

Wings curled upward; rarely overlaps wild type at 25^oC, but frequently overlaps at 19^oC. Curvature caused by the unequal contraction of the upper and lower epithelia during the drying period following emergence from the pupa case (Waddington, 1940). Flightless but thoracic innervation normal (Chiarodo, Reing and Saranchak, 1971). Expression decreased by larval crowding, increased by increased temperature during pupal development (Nozawa, 1956). Classifiable in single dose in triploids. Usually homozygous lethal but may emerge as dwarf with more extreme wing character. Effective lethal phase late embryo-early larva (Kidwell, 1972). Cy is readily revertable by both EMS and irradiation. In addition some balanced Cy chromosomes pick up suppressors of Cy in stock. RK1A.

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Duox^Cy has phenotype, suppressible by Su(Cy)¹

(Thompson, 1963)

Duox^Cy has phenotype, suppressible by Bl¹

(Meyer, 1952)

NOT suppressed by

Statement

Reference

Duox^Cy has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Hurd et al., 2015)

(Cook, 2008.12.1)

(Stefancsik, 2002.5.22)

Comments

Complementation test based on lethal phenotype.

(Stefancsik, 2002.5.22)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (365)

880

T(2;3)Scar, Scarred¹/Duox^Cy

359

nw²/In(2L)Cy, In(2R)NS, Duox^Cy

3548

Df(2L)al, ds^al/In(2L)Cy, Duox^Cy

382

Pfas¹⁰/In(2L)Cy, In(2R)Cy, Duox^Cy

2532

In(2L)Cy, Duox^Cy; T(2;3)E(da), E(da)¹

6505

Df(2R)XTED1/In(2LR)Gla, Duox^Cy wg^Gla-1

101514

In(2L)Cy In(2R)NS, Duox^Cy / nw²

106869

Df(2L)esc-P2-0/Duox^Cy amos^Roi-1

106870

Df(2L)esc-P3-0/Duox^Cy amos^Roi-1

107090

Df(2L)al, ds^al/In(2L)Cy, Duox^Cy

105881

Pfas¹⁰/In(2L)Cy, In(2R)Cy, Duox^Cy

108965

T(2;3)A1-W, In(2L)Cy, In(2R)Cy, Duox^Cy L¹

More stocks available...

Notes on Origin

Discoverer

Comments

Comments

The curly winged mutant phenotype can be suppressed by exposure to fluorescent light.

(Pavelka et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Cy

(Goldschmidt, 1999, Meyer, 1952)

Cy¹

(Hurd et al., 2015, Cook, 2008.12.1)

Duox^Cy

(Miller et al., 2018)

DuoxCy

(Erdi, 2020.4.4)

Name Synonyms

Curly

Secondary FlyBase IDs

References (23)

Report Sections