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General Information
Symbol
Dmel\dpylv1
Species
D. melanogaster
Name
lethal vortex
FlyBase ID
FBal0002850
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dpLV1, dptx
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the adult thorax result in a vortex phenotype.

Homozygous clones in the wing result in deformed wings with blisters.

When mutant clones are induced in the wing, a wing blister appears within a few minutes of eclosion of the adult flies from the pupal case.

Clones of mutant cells in the pupal wing still contain the transalar microtubule arrays that are normally seen spanning the wing cells at this stage.

At the ultrastructural level, homozygous embryos show a separation of the apical extracellular matrix (cuticle) from the apical surface of the epidermis. All elements of the external epicuticle appear to be properly formed and remain in tight contact with the upper layers of the endocuticle. However, the chitin layer of the endocuticle has disintegrated, especially towards its basal side. An electron dense layer, presumably corresponding to a defective deposition zone, is faint and discontinuous compared to the wild-type deposition zone, and its typical tight contact to the chitin layer above is lost. On the apical surface of the mutant epidermal cells, the typical microvilli can still be seen, often attached to the remaining fragments of the deposition zone. Junctional structures within the mutant epidermal cells appear normal. The apical and basal junctions of tendon cells are intracellularly connected by large microtubule bundles in the mutant embryos and at the apical side, long tonofilaments extend away into the extracellular space (as occurs in wild type). Normally, tonofilaments anchor in the cuticle, however, in the mutant embryos, they appear to have been pulled out. The basal adhesive junctions of the tendon cells appear normal in the mutant embryos and the attachment of the basal surface of the rest of the epidermal cells to the basement membrane also appears normal.

Transheterozygotes with dpD are lethal.

Thoracic vortex phenotype (v). dplv1/dpov1 has strong, volcano-like dorsocentral mounds or pits with brown pigmentation; comma effects striking; sternopleural bristles turned down; wings normal. At higher temperature (28oC), two additional pits anterior to dorsocentrals occasionally appear. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

dpylv1/dp[+] is an enhancer of visible | heat sensitive phenotype of Dcr-2UAS.cDa, EogtGD5084, Scer\GAL4en.PU

Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

dplv1 dominantly enhances the wing blistering phenotype seen in the posterior compartment of wings in flies expressing EogtGD5084 under the control of Scer\GAL4en.PU in the presence of Dcr-2Scer\UAS.cDa, such that the phenotype is seen at 22.5[o]C.

A dplv1 heterozygous background markedly increases the penetrance of wing blisters caused by expression of EogtNIG.9867R under the control of Scer\GAL4en-e16E.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

'Failure to complement' statements based on recessive lethality.

Images (0)
Mutant
Wild-type
Stocks (155)
Notes on Origin
Discoverer

Bridges, 3 March 1920.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
Reported As
Name Synonyms
dumpy-thoraxate
lethal vortex
thoraxate
Secondary FlyBase IDs
    References (9)