FlyBase Allele Report: Dmel\dsh[3]

General Information

Symbol

Dmel\dsh³

Species

D. melanogaster

Name

FlyBase ID

FBal0003140

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

Also Known As

dsh^V26, dsh^V6, l(1)V26, V26

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cadigan and Nusse, 1996, Yu et al., 1996, Manoukian et al., 1995, Perrimon and Mahowald, 1987)

loss of function allele

(Strutt et al., 2006, Zhang et al., 2006, Galindo et al., 2002)

Mutagen

ethyl methanesulfonate

(Hanratty and Dearolf, 1993, Perrimon and Mahowald, 1987, Geer et al., 1983)

Progenitor genotype

Cytology

Description

Deletion of the open reading frame between nucleotides 496 and 1040, resulting in a frameshift after amino acid residue 94.

(Wehrli and Tomlinson, 1998)

Deletion within the gene that removes, at least, part of the protein encoding domain.

(Yanagawa et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:11,356,637..11,357,179 [+]

Comment:

A deletion of 543 bases and insertion of one base that causes a frameshift after amino acid residue 94. The resulting sequence at the junction is ggtaacaatcTacggcgg.

(Wehrli and Tomlinson, 1998, Yanagawa et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

exacerbates cancer

modeled by Axn^{FGmut.UAS.GFP}

(Mendoza-Topaz et al., 2011)

ameliorates familial adenomatous polyposis 1

modeled by Apc2^f90, Apc^Q8

(Mendoza-Topaz et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell death | embryonic stage

(Perrimon and Mahowald, 1987)

abnormal planar polarity

(Kaplan and Tolwinski, 2010)

abnormal planar polarity, with dsh^K417R.EGFP

(Yanfeng et al., 2011)

abnormal planar polarity, with dsh^Y473F.EGFP

(Yanfeng et al., 2011)

abnormal planar polarity, with dsh^Y473F.EGFP, dsh^Y474F.EGFP

(Yanfeng et al., 2011)

abnormal planar polarity (with dsh¹)

(Penton et al., 2002)

abnormal planar polarity (with dsh^A3)

(Penton et al., 2002)

abnormal planar polarity | cell autonomous | recessive | somatic clone

(Strutt et al., 1997)

abnormal planar polarity | cell non-autonomous | recessive | somatic clone

(Wehrli and Tomlinson, 1998)

abnormal planar polarity | germline clone

(Kaplan and Tolwinski, 2010)

abnormal planar polarity | germline clone, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

(Kaplan and Tolwinski, 2010)

abnormal planar polarity | recessive | somatic clone

(Strutt et al., 1997)

abnormal planar polarity | somatic clone

(Yanfeng et al., 2011, Strutt et al., 2002)

increased cell number | somatic clone

(Xu et al., 2018)

lethal

(Yanfeng et al., 2011, Strutt et al., 2006, Zhimulev et al., 1987)

lethal | recessive

(Couso et al., 1994, Klingensmith et al., 1994, Theisen et al., 1994)

lethal - all die before end of larval stage

(Boutros et al., 1998, Geer et al., 1983)

lethal - all die before end of larval stage | recessive

(Perrimon et al., 1989)

lethal - all die before end of larval stage | recessive | rescuable maternal effect

(Perrimon and Mahowald, 1987)

lethal - all die during embryonic stage | recessive

(Klingensmith et al., 1996)

neoplasia | adult stage | somatic clone

(Wernet et al., 2003)

segment polarity phenotype | embryonic stage | maternal effect

(Mannava and Tolwinski, 2015)

segment polarity phenotype | germline clone

(Perrimon et al., 1989)

some die during embryonic stage | recessive

(Klingensmith et al., 1996)

some die during larval stage

(Boutros et al., 1998, Geer et al., 1983)

some die during larval stage | recessive

(Perrimon et al., 1989)

some die during larval stage | rescuable maternal effect

(Perrimon and Mahowald, 1987)

viable (with dsh¹)

(Penton et al., 2002)

visible

(Tomlinson, 2003)

visible | recessive | somatic clone

(Galindo et al., 2002)

Phenotype Manifest In

abdominal 1 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 2 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 3 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 4 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 5 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 6 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 7 ventral denticle belt

(Klingensmith et al., 1994)

abdominal 8 ventral denticle belt

(Klingensmith et al., 1994)

adult cuticle

(Heslip et al., 1997)

adult enteroendocrine cell | ectopic | somatic clone

(Xu et al., 2018)

adult head

(Heslip et al., 1997)

amnioserosa

(Kaltschmidt et al., 2002)

cephalopharyngeal skeleton

(Axelrod et al., 1998)

chaeta (with dsh¹)

(Penton et al., 2002)

denticle

(Peradziryi et al., 2011, Kaplan and Tolwinski, 2010)

denticle | germline clone

(Kaplan and Tolwinski, 2010)

denticle | germline clone, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

(Kaplan and Tolwinski, 2010)

denticle | maternal effect, with Scer\GAL4^arm.PS, dsh^ΔDIX.UAS

(Kaplan and Tolwinski, 2010)

denticle field | embryonic stage | maternal effect

(Mannava and Tolwinski, 2015)

dorsal margin photoreceptor cell | ectopic

(Wernet et al., 2003)

dorsal margin photoreceptor cell | somatic clone

(Tomlinson, 2003)

embryo | germline clone

(Perrimon et al., 1989)

embryonic/first instar larval cuticle

(Peradziryi et al., 2011, Axelrod et al., 1998)

embryonic/first instar larval cuticle, with Scer\GAL4^arm.PS, arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

embryonic/first instar larval cuticle | dorsal | germline clone

(Perrimon and Mahowald, 1987)

embryonic/first instar larval cuticle | germline clone

(Klingensmith et al., 1996)

embryonic/first instar larval cuticle | germline clone | maternal effect

(Morel and Arias, 2004)

embryonic/larval cuticle | embryonic stage | maternal effect

(Mannava and Tolwinski, 2015)

embryonic/larval spiracle primordium | germline clone | posterior

(Perrimon and Mahowald, 1987)

embryonic/larval tracheal dorsal trunk | germline clone

(Llimargas, 2000)

embryonic dorsal epidermis

(Kaltschmidt et al., 2002)

embryonic dorsal epidermis | germline clone | maternal effect

(Morel and Arias, 2004)

embryonic epidermis

(Kaplan and Tolwinski, 2010)

embryonic head

(Klingensmith et al., 1994)

embryonic head | germline clone

(Klingensmith et al., 1996)

embryonic leading edge cell

(Kaltschmidt et al., 2002)

embryonic leading edge cell & actin filament

(Kaltschmidt et al., 2002)

embryonic leading edge cell & filopodium

(Kaltschmidt et al., 2002)

embryonic leading edge cell & microtubule

(Kaltschmidt et al., 2002)

embryonic leading edge cell | germline clone | maternal effect

(Morel and Arias, 2004)

embryonic midgut constriction 2

(Yu et al., 1996)

embryonic midgut constriction 2 | embryonic stage

(Klingensmith et al., 1994)

embryonic ventral epidermis | germline clone

(Kaplan and Tolwinski, 2010)

eye | somatic clone

(Janody et al., 2004)

eye disc | somatic clone

(Janody et al., 2004)

eye photoreceptor cell | somatic clone

(Strutt et al., 2002)

filzkorper

(Axelrod et al., 1998, Klingensmith et al., 1994)

filzkorper | germline clone

(Klingensmith et al., 1996, Perrimon and Mahowald, 1987)

follicle stem cell | somatic clone

(Kirilly et al., 2005)

larval tracheal system | germline clone

(Llimargas, 2000)

leg

(Jiang and Struhl, 1996)

leg | somatic clone

(Galindo et al., 2002)

leg | somatic clone | ventral

(Klingensmith et al., 1994)

leg disc

(Jiang and Struhl, 1996)

macrochaeta & wing

(Couso et al., 1994)

macrochaeta | ectopic

(Heslip et al., 1997)

medial row of triple row of wing sensilla

(Rulifson et al., 1996)

mesothoracic ventral denticle belt

(Klingensmith et al., 1994)

metathoracic ventral denticle belt

(Klingensmith et al., 1994)

ocellus | ectopic

(Heslip et al., 1997)

ommatidium

(Tomlinson et al., 1997)

ommatidium | cell autonomous | somatic clone

(Strutt et al., 1997)

ommatidium | cell non-autonomous | somatic clone

(Wehrli and Tomlinson, 1998)

ommatidium | ectopic

(Heslip et al., 1997)

ommatidium | somatic clone

(Strutt et al., 2002)

ommatidium | somatic clone | increased number

(Tomlinson, 2003)

photoreceptor neuron | somatic clone

(Janody et al., 2004)

pigment cell | somatic clone

(Tomlinson, 2003)

prothoracic ventral denticle belt

(Klingensmith et al., 1994)

secondary pigment cell | somatic clone

(Lim and Tomlinson, 2006)

stomodeal invagination

(Gonzalez-Gaitan and Jäckle, 1995)

tertiary pigment cell | somatic clone

(Lim and Tomlinson, 2006)

trichome (with dsh¹)

(Penton et al., 2002)

triple row of wing sensilla | somatic clone

(Klingensmith et al., 1994)

ventral denticle belt

(Axelrod et al., 1998, Manoukian et al., 1995)

ventral denticle belt, with Scer\GAL4^arm.PS, arr::dsh^{DIX-ctail.UAS}

(Metcalfe et al., 2010)

wing

(Axelrod et al., 1996)

wing & macrochaeta

(Axelrod et al., 1996)

wing & triple row | somatic clone

(Klingensmith et al., 1994)

wing margin bristle | ectopic

(Couso et al., 1994)

Detailed Description

Statement

Reference

dsh³/+ flies display wild-type hair patterns on the wing, thorax and eyes.

(Shami Shah et al., 2019)

The induction of dsh³ clones in renal tubules leads to ectopic enteroendocrine-like cells (e.g. Pros-positive cells), as compared to controls.

(Xu et al., 2018)

dsh^EGFP.N, dsh³ individuals exhibit normal wings, although trichomes are slightly longer than normal, although polarity is normal.

(Strutt et al., 2016)

Maternally and zygotically mutant dsh³ embryos (coming from mothers whose whole germline constitutes from dsh³ mutant cells only - created by the OvoD germline clone technique) show a segment polarity phenotype and no naked cuticle between denticle belts on the ventral epidermis (resulting in a lawn of denticles).

(Mannava and Tolwinski, 2015)

Heterozygous dsh³ mutant flies have normal wings.

(Vuong et al., 2014)

All epidermal cells secrete denticles in embryos which are maternally and zygotically mutant for dsh.

(Peradziryi et al., 2011)

Flies expressing dsh^{Y473F.T:Avic\GFP-EGFP} in a dsh³ mutant background display strong PCP defects in all tissues analysed, including classical PCP defects in the thorax and wings, rough eyes with randomised chirality, symmetrical clusters and misrotation. Co-expression of dsh^{Y474F.T:Avic\GFP-EGFP} does not enhance these phenotypes.

Flies expressing dsh^{Y474F.T:Avic\GFP-EGFP} in a dsh³ background display wild type PCP patterns in all tissues analysed.

(Yanfeng et al., 2011)

dsh³ maternal/zygotic clones (expressing dsh^{ΔDIX.Scer\UAS} under the control of Scer\GAL4^arm.PS to remove the mild polarity defect of dsh³) display strong denticle alignment defects.

Maternal dsh³ mutants (expressing dsh^{ΔDIX.Scer\UAS} under the control of Scer\GAL4^arm.PS to remove the mild polarity defect of dsh³) show a loss of denticles.

dsh³ mutants display strong patterning defects, and all epidermal cells make denticle precursors.

dsh³ maternal/zygotic mutant embryos show a ventral epidermis covered with denticles, and the naked regions of cuticle which separates the denticle belts in wild-type embryos are absent in these mutants. Every cell secretes a denticle, and denticle placement is not properly oriented toward the posterior of each cell. All ventral cells display a uniform square shape and lack normal alignment.

dsh³ maternal effect mutants display wild-type cuticles.

(Kaplan and Tolwinski, 2010)

Expression of dsh^{DIX.Scer\UAS.T:ctail-arr} in dsh³ mutants under the control of Scer\GAL4^arm.PS produces embryos with completely naked cuticles.

(Metcalfe et al., 2010)

Homozygous clones in the pupal wing (23 hours after puparium formation) do not affect polarity of trichomes in surrounding wild-type tissue.

(Strutt and Strutt, 2007)

In clones mutant for dsh³, the peripheral ommatidia do not undergo programmed cell death and so fail to release their associated 2^o and 3^o pigment cells to join the pigment rim. As a consequence, the pigment rim in dsh³ clones is significantly reduced in relation to neighbouring wild-type tissue.

(Lim and Tomlinson, 2006)

Unlike neutral somatic clones, dsh³ homozygous somatic clones are rapidly lost from the somatic stem cell population of the germarium.

(Kirilly et al., 2005)

When clones are made in the eye disc ectopic dorsal furrows are induced.

(Janody et al., 2004)

The cuticles of embryos from dsh³ germline clones have an anterodorsal hole and are very short with most of the dorsal epidermis missing. At stage 13 in these embryos the leading edge cells fail to polarise or elongate dorso-ventrally.

(Morel and Arias, 2004)

Germband extension occurs normally in dsh³ homozygous embryos from mothers carrying dsh³ germ line clones. Polarisation of germband cells during germband extension also appears normal in these embryos.

(Zallen and Wieschaus, 2004)

Clones expressing dsh³ that are induced at the dorsal periphery of the eye show a loss of pigment rim tissue and an associated gain of extra ommatidia that extend almost to the head capsule. These extra ommatidia have a variable number of cells and many do not extend the depth of the retina. Some of these clones show an absence of dorsal rim ommatidia, while these are present in other clones.

(Tomlinson, 2003)

Homozygous clones in the eye result in large clonal outgrowths. Additional rows of dorsal rim area ommatidia are seen in wild-type tissue adjacent to homozygous clones, probably due to overproliferation.

(Wernet et al., 2003)

Homozygous clones generated at 72 hours after egg laying do not produce distal truncations of the leg, although leg polarity is abnormal.

(Galindo et al., 2002)

During dorsal closure in dsh³ mutant embryos, frequent detachments of the amnioserosa from the epidermis occur. The leading edge cells lack filopodial activity, and have only a thin cable of actin, lacking distinguishable actin nucleation centers. In additions, these cells do not undergo D-V elongation or D-V polarization. One manifestation of this is that the microtubule bundles that form in these cells do not align perpendicular to the leading edge.

(Kaltschmidt et al., 2002)

dsh¹/dsh³ flies have planar polarity defects, resulting in an aberrant orientation of bristles and hairs.

(Penton et al., 2002)

Somatic clones of dsh³ in the eye produce long-range nonautonomous inversions of ommatidial polarity on their equatorial edge.

(Strutt and Strutt, 2002)

34% of ommatidia in homozygous mutant somatic clones in the eye are normal. 16.3% have rotated ommatidia, 38.3% have chirality defects, 11.3% are achiral (0% unscorable).

(Strutt et al., 2002)

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

Embryos derived from homozygous female germline clones show defects in tracheal invagination, branch fusion and dorsal trunk formation.

(Llimargas, 2000)

Mutant embryos show shortening of the cuticle, fusion of denticle bands and absence the head skeleton and filzkorper.

(Axelrod et al., 1998)

Homozygous clones in polar regions of the eye show non-autonomous effects, with polarity inversion in tissue lying equatorial to the clone. Polarity errors are also seen within the clone. Clones elsewhere in the eye rarely show non-autonomous effects, but when they do, polarity inversions are seen on the equatorial side of the clone.

(Wehrli and Tomlinson, 1998)

Clones in the eye-antennal disc that normally gives rise to head cuticle can cause ectopic ommatidia, ocelli or sensilla to develop.

(Heslip et al., 1997)

Homozygous clones in the eye show an autonomous tissue polarity defect; ommatidia frequently show abnormal orientation and chirality.

(Strutt et al., 1997)

Ommatidial orientations are disturbed, chiral shape is choosen randomly.

(Tomlinson et al., 1997)

Large clones induced in the wing before 72hr AEL are associated with a notch in the wing margin. Small clones (induced after 72hr AEL) often leave the margin intact but fail to elaborate bristles.

(Axelrod et al., 1996)

Homozygous clones in the eye have interommatidial bristles.

(Cadigan and Nusse, 1996)

When clones are induced in the wing disc, a second set of concentric folds forms in the disc epithelium, which may reflect the formation of a secondary proximo-distal axis. Mutant cells give rise to dorsal rather than ventral structures in the adult and can organize surrounding wild type cells to contribute to supernumerary legs, which branch out from the ventral surface of the normal leg.

(Jiang and Struhl, 1996)

Embryos derived from germline clones exhibit an extreme segment polarity phenotype in which naked cuticle and segmental furrows are replaced by a lawn of denticles. Head skeleton and filzkorpers fail to develop and the embryos fail to hatch.

(Klingensmith et al., 1996)

In clones in the adult wing, ectopic bristles form off the wing margin in a wg-dosage-dependent fashion.

(Rulifson et al., 1996)

In homozygous embryos the second constriction is missing.

(Yu et al., 1996)

Only one central invagination fold of the stomodeal invagination is observed.

(Gonzalez-Gaitan and Jäckle, 1995)

Embryos exhibit a lawn of denticle belts.

(Manoukian et al., 1995)

Sections of dsh¹-dsh³ double mutant eyes show a disturbed ommatidial polarity within each ommatidium having the normal arrangement of photoreceptor cells.

(Zheng et al., 1995)

Clones of cells in the wing display different phenotypes depending on the position of the clone within the wing blade. Cells within the wing blade show abnormalities in differentiation related to a function of dsh in tissue polarity. When clones reach the margin they behave as if they were in the middle of the wing blade, developing trichomes and non-pigmented cuticle. Cells outside these clones are induced to form ectopic bristles characteristic of the margin (this also occurs for arm clones. Clones of cells simultaneously mutant for both dsh and sgg do not produce a dsh mutant phenotype at the wing margin, but display the phenotype of cells mutant for sgg alone.

(Couso et al., 1994)

When both maternal and zygotic components of dsh are lacking, dsh embryos display patterning defects identical to those for wg null mutants such as wg^l-17 : no segment borders form to define segments, the usual naked regions of cuticle are not seen and filzkorper and head structures are missing. The second midgut constriction fails to form. Clonal analysis reveals that dsh is required for patterning but not viability of ventral cells in the leg, with dsh clones producing supernumerary appendages from the ventral face. Wing clones show supernumerary cells in the triple row.

(Klingensmith et al., 1994)

Clonal analysis revealed polarity defects in adult tissues as for dsh¹, and that dsh is required autonomously for cell polarity. Similar mutant leg phenotypes, e.g. duplications and bifurcations, are produced by dsh clones, dsh, wg double heterozygotes and wg mutants. There is allele specificity in these interactions.

(Theisen et al., 1994)

dsh³ embryos have a wg-like phenotype. In dsh³ embryos arm stripes could not be detected.

(Riggleman et al., 1990)

Females possessing homozygous germline clones when mated to wild type males produce two classes of embryos: heterozygous females are fertile and morphogenetically normal and hemizygous male embryos lack dorsal cuticle, posterior spiracles and filzkorper material. The ventral cuticle present has no naked cuticle in the thoracic or abdominal segments. Embryos show an aberrant pattern of cell death and lack of parasegmental and segmental boundaries.

(Perrimon and Mahowald, 1987)

larval lethal maternal-effect, partially rescuable by wild type sperm

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

dsh³ has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

Suppressed by

Statement

Reference

dsh³ has lethal phenotype, suppressible by Abl²/dsh^Y473F.EGFP/Abl[+]

(Yanfeng et al., 2011)

dsh³ has abnormal planar polarity phenotype, suppressible by Scer\GAL4^arm.PS/arm^{S56A.UAS.Tag:polyHis.Tag:MYC}

(Kaplan and Tolwinski, 2010)

NOT suppressed by

Statement

Reference

dsh³ has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has segment polarity phenotype | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

Enhancer of

Statement

Reference

dsh³ is an enhancer of visible phenotype of Scer\GAL4^unspecified, nkd^UAS.cZa

(Zeng et al., 2000)

dsh³ is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

dsh³ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

dsh³ is an enhancer of visible phenotype of Scer\GAL4^69B, fz^UAS.N

(Zhang and Carthew, 1998)

NOT Enhancer of

Statement

Reference

dsh³/dsh[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh³ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh³ is a non-enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh³ is a non-enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

Suppressor of

Statement

Reference

dsh³/dsh[+] is a suppressor | partially of visible | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh³/dsh[+] is a suppressor | partially of decreased size | adult stage phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh³/dsh[+] is a suppressor | partially of abnormal size phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

dsh³/dsh[+] is a suppressor | partially of visible phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

dsh³/dsh[+] is a suppressor of increased cell death | third instar larval stage phenotype of Scer\GAL4^ptc-559.1, hep^UAS.cBa

(Zhang et al., 2015)

dsh³/dsh[+] is a suppressor of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, dco^UAS.cKa

(Klein et al., 2006)

dsh³/dsh[+] is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

dsh³ is a suppressor of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

dsh³ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

dsh³ is a suppressor of visible phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

dsh³ is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

NOT Suppressor of

Statement

Reference

dsh³ is a non-suppressor of lethal | maternal effect phenotype of Scer\GAL4^Act.PU, wntD^UASp.cEa

(McElwain et al., 2011)

dsh³/dsh[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh³/dsh³ is a non-suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of Vang^stbm-6

(Strutt and Strutt, 2007)

dsh³/dsh³ is a non-suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz²¹

(Strutt and Strutt, 2007)

dsh³ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh³ is a non-suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

Other

Statement

Reference

dsh³/dsh[+], kmr¹ has visible | adult stage phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr¹ has abnormal planar polarity | adult stage phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has visible | adult stage phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has abnormal planar polarity | adult stage phenotype

(Shami Shah et al., 2019)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has abnormal cell polarity | adult stage phenotype

(Strutt et al., 2016)

Klp64D^k1, dsh³/dsh[+] has visible | dominant phenotype

(Vuong et al., 2014)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

dsh³ has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | embryonic stage | maternal effect phenotype, non-enhanceable by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has phenotype, non-enhanceable by nkd³

(Rousset et al., 2001)

Suppressed by

Statement

Reference

dsh³ has denticle phenotype, suppressible by Scer\GAL4^arm.PS/arm^{S56A.UAS.Tag:polyHis.Tag:MYC}

(Kaplan and Tolwinski, 2010)

dsh³ has embryonic epidermis phenotype, suppressible by Scer\GAL4^arm.PS/arm^{S56A.UAS.Tag:polyHis.Tag:MYC}

(Kaplan and Tolwinski, 2010)

dsh³ has follicle stem cell | somatic clone phenotype, suppressible by Scer\GAL4^Act5C.PI/tkv^Q199D.UAS

(Kirilly et al., 2005)

dsh³ has embryonic leading edge cell | germline clone | maternal effect phenotype, suppressible by sgg^M11

(Morel and Arias, 2004)

dsh³ has embryonic/first instar larval cuticle | germline clone | maternal effect phenotype, suppressible by sgg^M11

(Morel and Arias, 2004)

NOT suppressed by

Statement

Reference

dsh³ has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has embryonic/larval cuticle | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:Myr(Src64B),Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^UAS.Tag:HA/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has denticle field | maternal effect | embryonic stage phenotype, non-suppressible by sgg^{KK-MI.UAS.Tag:HA}/Scer\GAL4^arm.PU

(Mannava and Tolwinski, 2015)

dsh³ has phenotype, non-suppressible by nkd³

(Rousset et al., 2001)

Enhancer of

Statement

Reference

dsh³/dsh[+] is an enhancer of leg joint phenotype of ds¹/ds⁰⁵¹⁴²

(Rodriguez, 2004)

dsh³/dsh[+] is an enhancer of leg phenotype of ds¹/ds⁰⁵¹⁴²

(Rodriguez, 2004)

dsh³/dsh[+] is an enhancer of tarsal segment phenotype of ds¹/ds⁰⁵¹⁴²

(Rodriguez, 2004)

dsh³ is an enhancer of wing margin phenotype of Scer\GAL4^en-e16E, fz^{1-1-1.UAS.Tag:MYC}

(Wu et al., 2004)

dsh³ is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

dsh³ is an enhancer of wing phenotype of Scer\GAL4^en-e16E, shg^{i.UAS.Tag:SS(aos),Tag:MYC}

(Greaves et al., 1999)

NOT Enhancer of

Statement

Reference

dsh³/dsh[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh³ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh³ is a non-enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh³ is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

dsh³ is a non-enhancer of interneuron phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

dsh³ is a non-enhancer of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Suppressor of

Statement

Reference

dsh³/dsh[+] is a suppressor | partially of eye phenotype of Nab2^EP3716, Scer\GAL4^GMR.PU

(Lee et al., 2020)

dsh³/dsh[+] is a suppressor | partially of scutellum phenotype of Scer\GAL4^pnr-MD237, hep^UAS.cBa

(Zhang et al., 2015)

dsh³/dsh[+] is a suppressor | partially of anterior crossvein phenotype of Scer\GAL4^ptc-559.1, hep^UAS.cBa

(Zhang et al., 2015)

dsh³/dsh[+] is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, dco^UAS.cKa

(Klein et al., 2006)

dsh³/dsh[+] is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^hs.2sev, dco^UAS.cKa

(Klein et al., 2006)

dsh³/dsh[+] is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

dsh³ is a suppressor of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

dsh³ is a suppressor of wing phenotype of Scer\GAL4^en-e16E, arm^UAS.cWa

(Greaves et al., 1999)

dsh³ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, arm^UAS.cWa

(Greaves et al., 1999)

dsh³ is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

NOT Suppressor of

Statement

Reference

dsh³/dsh[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh³/dsh³ is a non-suppressor of wing hair | somatic clone | cell non-autonomous | pupal stage phenotype of fz²¹

(Strutt and Strutt, 2007)

dsh³/dsh³ is a non-suppressor of wing hair | somatic clone | cell non-autonomous | pupal stage phenotype of Vang^stbm-6

(Strutt and Strutt, 2007)

dsh³ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dsh³ is a non-suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

dsh³ is a non-suppressor of interneuron phenotype of Scer\GAL4^eg-Mz360, drl^UAS.cCa

(Yoshikawa et al., 2003)

dsh³ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

dsh³ is a non-suppressor of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

dsh³ is a non-suppressor of abdominal 1 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 2 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 3 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 4 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 5 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 6 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

dsh³ is a non-suppressor of abdominal 7 ventral denticle belt phenotype of sgg^M11

(Siegfried et al., 1994)

Other

Statement

Reference

dsh³/dsh[+], kmr¹ has trichome phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr¹ has notum phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has wing hair phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has interommatidial bristle phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has trichome phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr² has notum phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr¹ has wing hair phenotype

(Shami Shah et al., 2019)

dsh³/dsh[+], kmr¹ has interommatidial bristle phenotype

(Shami Shah et al., 2019)

Vang^stbm-6, dgo³⁸⁰, dsh³, pk^pk-sple-13 has wing hair phenotype

(Strutt et al., 2016)

Klp64D^k1, dsh³/dsh[+] has wing margin phenotype

(Vuong et al., 2014)

Klp64D^k1, dsh³/dsh[+] has wing margin bristle phenotype

(Vuong et al., 2014)

Scer\GAL4^arm.PS, arm^{S56A.UAS.Tag:polyHis.Tag:MYC}, dsh³ has denticle phenotype

(Kaplan and Tolwinski, 2010)

dsh³, l(2)gl⁴ has denticle phenotype

(Kaplan and Tolwinski, 2010)

dsh³, l(2)gl⁴ has embryonic ventral epidermis phenotype

(Kaplan and Tolwinski, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Double-heterozygous flies of the genotype dsh[3]/+ together with either kmr¹/+ or kmr²/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.

(Shami Shah et al., 2019)

dsh³, Vang^stbm-6, dgo³⁸⁰, pk^pk-sple-13 quadruple heterozygotes exhibit mild wing trichome orientation defects in proximal regions.

(Strutt et al., 2016)

The segment polarity phenotype and the lack of naked cuticle between denticle belts, resulting in a lawn of denticles on the ventral epidermis, characteristic for maternally and zygotically mutant dsh³ embryos is not modified by Scer\GAL4^arm.PU-driven expression of any of the following: sgg^{Scer\UAS.T:Myr-Src64B,T:Ivir\HA1}, sgg^{KK-MI.Scer\UAS.T:Myr-Src64B,T:Ivir\HA1}, sgg^{Scer\UAS.T:Ivir\HA1} or sgg^{KK-MI.Scer\UAS.T:Ivir\HA1}.

(Mannava and Tolwinski, 2015)

In contrast to either mutation alone, flies heterozygous for Klp64D^k1 and dsh³ show loss of wing bristles and wing margin notching.

(Vuong et al., 2014)

Expression of dsh^{Y473F.T:Avic\GFP-EGFP} in a Abl²/+ mutant background partially rescues the lethality seen in dsh³. The PCP defects are not rescued.

(Yanfeng et al., 2011)

dsh³ maternal/l(2)gl⁴ zygotic double mutants display a cuticle which resembles the l(2)gl⁴ maternal mutant phenotype. Patches of denticles are observed which lack proper alignment, and the ventral epithelium is continuous and formed. Denticle precursors are not properly oriented toward the posterior of cells and denticle placement appears to be random within each cell.

dsh³ germ-line clones expressing arm^{S56A.Scer\UAS.T:Zzzz\His6.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS restores some pattern, but a strong denticle alignment phenotype remains.

Embryos expressing arm^{S56A.Scer\UAS.T:Zzzz\His6.T:Hsap\MYC} under the control of Scer\GAL4^arm.PS in a maternal dsh³ background display a complete absence of denticles.

(Kaplan and Tolwinski, 2010)

dsh³ fz²¹/fz²¹ clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes towards the clone, as occurs with fz²¹/fz²¹ single mutant clones in the pupal wing.

dsh³ Vang^stbm-6/Vang^stbm-6 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes away from the clone, as occurs with Vang^stbm-6/Vang^stbm-6 single mutant clones in the pupal wing.

(Strutt and Strutt, 2007)

Expression of dco^Scer\UAS.cKa under the control of Scer\GAL4^hs.2sev in a dsh³/+ background completely suppresses the planar cell polarity and photoreceptor number phenotypes seen when dco^Scer\UAS.cKa is expressed in a wild-type background.

(Klein et al., 2006)

The rapid loss of smo³ homozygous somatic clone cells from the somatic stem cell population of the germarium is significantly suppressed if the clone cells are also tkv^{Q199D.Scer\UAS}; Scer\GAL4^Act5C.PI (Scer\GAL80 method).

(Kirilly et al., 2005)

Unlike embryos from dsh³ germline clones, embryos from dsh³; sgg^M11 germ-line clones have no dorsal hole in their cuticles (although their dorsal cuticle is severely puckered), and have a dorso-ventrally polarised and extended leading edge at stage 13.

(Morel and Arias, 2004)

dsh³/+ enhances the severity of leg phenotypes in ds⁰⁵¹⁴²/ds¹ animals: The length of the segments is reduced and most of the tarsal joints very reduced or completely absent.

(Rodriguez, 2004)

The addition of dsh³ has no effect on the interneuron phenotype seen in drl^Scer\UAS.cCa, Scer\GAL4^eg-Mz360 animals.

(Yoshikawa et al., 2003)

In crosses between nkd³/+, dsh³ flies and nkd³/+ flies, no enhancement or suppression of the dsh³ phenotype is seen.

(Rousset et al., 2001)

Has no effect on the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

Enhances wing margin phenotype of fz^Scer\UAS.N, Scer\GAL4^69B.

(Zhang and Carthew, 1998)

Embryos derived from homozygous doubly mutant germ lines, receiving neither maternal or zygotic wild type product, for sgg^M11 and dsh³ lack denticles on the ventral cuticle.

(Siegfried et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dsh³ is rescued by dsh^S254A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^Y24F.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T36A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T252A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S266A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S271A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^Y280F.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S283A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T314A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T349A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S406A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T419A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S451A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T462A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T467A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S469A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^Y474F.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S406E.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^T419E.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^S451E.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^DEP6A.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^C-term2.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^{C-term1-2.EGFP}

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^{C-term1-3.EGFP}

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^{C-term2-3.EGFP}

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^{C-term5Y-F.EGFP}

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^ΔC.EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^EGFP

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^Tag:FLAG

(Yanfeng et al., 2011)

dsh³ is rescued by dsh^ST5.EGFP

(Strutt et al., 2006)

dsh³ is rescued by dsh^UAS.cAa/Scer\GAL4^da.G32

(Morel and Arias, 2004)

dsh³ is rescued by dsh^{CK2.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{ST45.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{ST1.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{ΔBasic.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{CK4.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{fl.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{ST124.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{ST4.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^{CK3.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is rescued by dsh^EGFP

(Axelrod, 2001)

dsh³ is rescued by dsh^HindIII

(Marsh et al., 2000)

dsh³ is rescued by dsh^Q27

(Marsh et al., 2000)

dsh³ is rescued by dsh^hs.sev.B

(Boutros et al., 1998)

dsh³ is rescued by dsh^ΔC.hs.sev

(Boutros et al., 1998)

dsh³ is rescued by dsh^1.hs.sev

(Boutros et al., 1998)

dsh³ is rescued by dsh^ΔDIX.hs.sev

(Boutros et al., 1998)

dsh³ is rescued by dsh^ΔPDZ.hs.sev

(Boutros et al., 1998)

Partially rescued by

dsh³ is partially rescued by dsh^EGFP

(Capilla et al., 2012)

dsh³ is partially rescued by dsh^1.EGFP

(Capilla et al., 2012)

dsh³ is partially rescued by dsh^mut6.EGFP

(Capilla et al., 2012)

dsh³ is partially rescued by dsh^Y473F.EGFP

(Yanfeng et al., 2011)

dsh³ is partially rescued by dsh^K417R.EGFP

(Yanfeng et al., 2011)

dsh³ is partially rescued by dsh^1.EGFP

(Yanfeng et al., 2011)

dsh³ is partially rescued by dsh^KR.E.2x.GFP

(Simons et al., 2009)

dsh³ is partially rescued by dsh^ST8.EGFP

(Strutt et al., 2006)

dsh³ is partially rescued by dsh^ΔQ

(Marsh et al., 2000)

dsh³ is partially rescued by dsh^Q108

(Marsh et al., 2000)

dsh³ is partially rescued by dsh^1.tAa

(Axelrod et al., 1998)

Not rescued by

dsh³ is not rescued by dsh^KR.E.5x.GFP

(Simons et al., 2009)

dsh³ is not rescued by dsh^{ΔDEPD-2.hs.Tag:MYC}

(Penton et al., 2002)

dsh³ is not rescued by dsh^{ΔPDZ.hs.Tag:MYC}

(Penton et al., 2002)

Comments

dsh^{mut6.T:Avic\GFP-EGFP} rescues the embryonic lethality of dsh³ animals. The resulting adults have largely wild-type wings and both leg bristles and wing hairs show normal planar polarisation. The rescued adults show a strong ectopic leg joint phenotype.

dsh³ animals rescued to adulthood by dsh^{1.T:Avic\GFP-EGFP} show a strong ectopic leg joint phenotype.

Some dsh³ animals rescued to adulthood by dsh^{T:Avic\GFP-EGFP} show an ectopic leg joint phenotype.

(Capilla et al., 2012)

Expression of dsh^{T:Avic\GFP-EGFP} fully rescues the lethality seen in dsh³ mutants.

Expression of dsh^T:Zzzz\FLAG fully rescues the lethality and PCP defects seen in dsh³ mutants.

Expression of dsh^{T36A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T252A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S254A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S266A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S271A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{Y280F.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S283A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T314A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T349A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S406A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T419A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S451A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T462A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T467A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S469A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{Y474F.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S406E.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{T419E.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{S451E.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{DEP6A.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{C-term2.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{C-term1-2.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{C-term1-3.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{C-term2-3.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{C-term5Y-F.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{ΔC.T:Avic\GFP-EGFP} fully rescues the lethality and PCP defects seen in dsh³.

Expression of dsh^{1.T:Avic\GFP-EGFP} partially rescues the lethality seen in dsh³. The PCP defects are not rescued.

Expression of dsh^{Y473F.T:Avic\GFP-EGFP} partially rescues the lethality seen in dsh³. The PCP defects are not rescued.

Expression of dsh^{K417R.T:Avic\GFP-EGFP} partially rescues the lethality seen in dsh³. The PCP defects are not rescued.

(Yanfeng et al., 2011)

Expression of dsh^{ST8.T:Avic\GFP-EGFP} rescues the lethality of dsh³ mutants.

(Strutt et al., 2006)

dsh^Scer\UAS.cAa; Scer\GAL4^da.G32 rescues the cuticles of embryos from dsh³ germline clones to normal length and suppresses the hole anterodorsal cuticle hole.

(Morel and Arias, 2004)

dsh^ΔQ rescues the lethality of dsh³ flies, but a small fraction of the survivors have mild polarity and patterning defects.

dsh^Q108 shows only 24% rescue of the lethality of dsh³ flies. The surviving adults have polarity and patterning defects including notched wings, disordered bristles and bifurcated legs.

(Marsh et al., 2000)

dsh³ flies carrying dsh^1.tAa are viable and have a dsh¹ phenotype. Mutant embryos show shortening of the cuticle, fusion of denticle bands and absence the head skeleton and filzkorper. This phenotype is completely rescued by injection of dsh^cAa or dsh^ΔbPDZ mRNA, partially rescued by injection of dsh^ΔDIX or dsh^ΔEP+ mRNA, and is not rescued by injection of dsh^ΔDEP+, dsh^DIX, dsh^bPDZ or dsh^DEP+ mRNA.

(Axelrod et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

6331

w^* dsh³ P{neoFRT}19A/FM7a

5299

y¹ w¹ dsh³ f^36a/FM7a

41773

w^* dsh³ f¹ P{neoFRT}19A; P{dsh-eGFP.Y473F}B/TM6

Kyoto

108158

y¹ w¹ dsh³ f^36a/FM7a

Notes on Origin

Discoverer

Comments

Maternal germline clonal analysis demonstrates a maternal effect, defects in segment polarity.

(Perrimon et al., 1989)

Mosaic analysis in the embryo revealed that the requirement for dsh product is cell autonomous.

(Klingensmith et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

(Weber et al., 2012)

V26

(Weber et al., 2012, Geer et al., 1983)

dsh^V26

(Strutt et al., 2023, Mieszczanek et al., 2022, Strutt et al., 2019, Katanaev et al., 2018, Ressurreição et al., 2018, Kaur et al., 2017, Warrington et al., 2017, Strutt et al., 2016, Wang et al., 2016, Mannava and Tolwinski, 2015, Zhang et al., 2015, Strutt et al., 2013, Strutt et al., 2013, Peradziryi et al., 2011, Strutt et al., 2011, Yanfeng et al., 2011, Colosimo et al., 2010, Kaplan and Tolwinski, 2010, Simons et al., 2009, Wu et al., 2008, del Alamo and Mlodzik, 2006, Zhang et al., 2006, Amonlirdviman et al., 2005, Dollar et al., 2005, Morel and Arias, 2004, Tolwinski and Wieschaus, 2004, Wu et al., 2004, Zallen and Wieschaus, 2004, Tolwinski et al., 2003, Tomlinson, 2003, Wernet et al., 2003, Cohen et al., 2002, Galindo et al., 2002, Strutt et al., 2002, Shimada et al., 2001, Azpiazu and Morata, 2000, Fanto, 2000, Fanto et al., 2000, Marsh et al., 2000, Zeng et al., 2000, Greaves et al., 1999, Boutros et al., 1998, Wehrli and Tomlinson, 1998, Tomlinson et al., 1997, Cadigan and Nusse, 1996, Jiang and Struhl, 1996, Noordermeer et al., 1995, Yanagawa et al., 1995, Siegfried et al., 1994, van den Heuvel et al., 1993)

dsh^V6

(Rodriguez, 2004)

dsh^v26

(Banerjee et al., 2017, Mannava and Tolwinski, 2015, Vuong et al., 2014, Capilla et al., 2012, Mendoza-Topaz et al., 2011, Metcalfe et al., 2010, Klein et al., 2006, Lim and Tomlinson, 2006, Jenny et al., 2005, Das et al., 2004, Janody et al., 2004, Cliffe et al., 2003, Jenny et al., 2003, Kaltschmidt et al., 2002, Nakagoshi et al., 2002, Penton et al., 2002, Axelrod, 2001, Rousset et al., 2001, Sudarsan et al., 2001, Llimargas, 2000, Brennan et al., 1999, Helms et al., 1999, Axelrod et al., 1998, Martinez Arias, 1998, Park et al., 1998, Zhang and Carthew, 1998, Heslip et al., 1997, Micchelli et al., 1997, Axelrod et al., 1996, Klingensmith et al., 1996, Rulifson et al., 1996, Yu et al., 1996, Gonzalez-Gaitan and Jäckle, 1995, Manoukian et al., 1995, Zheng et al., 1995, Couso and Martinez Arias, 1994, Couso et al., 1994, Klingensmith et al., 1994, Noordermeer et al., 1994, Siegfried et al., 1994, Theisen et al., 1994, Perrimon et al., 1989, Perrimon and Mahowald, 1987, Zhimulev et al., 1987)

dsh^v6

(Joshi et al., 2006)

dsh[V26]

(Katanaev et al., 2005)

l(1)V26

(Riggleman et al., 1990)

l(1)dsh^v26

(Hanratty and Dearolf, 1993)

l(1)v26

(Geer et al., 1983)

Name Synonyms

Secondary FlyBase IDs

References (130)

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