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General Information
Symbol
Dmel\EgfrE1
Species
D. melanogaster
Name
Ellipse
FlyBase ID
FBal0003526
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
egfrElp, Elp1, Elp, Ellipse, dEGFRElp, Ellipse1, DERElp, EgfrElp1, DERElp1
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C21523103A

Reported nucleotide change:

C14A

Amino acid change:

S5R | Egfr-PA

Reported amino acid change:

S5R

Comment:

One of two nucleotide substitutions affecting the amino acid sequence in the EgfrE1 mutant relative to the reference sequence.

point mutation
Nucleotide change:

G21557607A

Reported nucleotide change:

G3165A

Amino acid change:

A887T | Egfr-PA; A936T | Egfr-PB

Reported amino acid change:

A887T

Comment:

One of two nucleotide substitutions affecting the amino acid sequence in the EgfrE1 mutant relative to the reference sequence. A L21W change is also reported in FBrf0105872 but a W already exists at this location in the reference sequence.

Associated Sequence Data
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: S5R. Amino acid replacement: L21W. Amino acid replacement: A887T. Figure 1 and the text concerning this allele are at odds - the text is correct (note from N. Baker).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygous eyes are small and rough.

The number of ommatidial clusters is significantly reduced in EgfrE1/+ larval eye discs, resulting in a small rough eye phenotype.

Mutant flies have an extra wing vein phenotype with an additional vein fragment above vein L2 and some vein deltas.

EgfrE1 heterozygous flies display abnormal wing vein morphology. This phenotype is compromised by treatment with the Hsp90 inhibitor 17-AAG.

Heterozygotes have extra wing vein material in the wing.

Heterozygotes have a rough eye phenotype.

In EgfrE1/+ adults, the number of ommatidia with pale-type R8 cells and yellow-type R7 cells is significantly increased. Many of these are found in pale-yellow hybrid ommatidia with a yellow-type R7 and a pale-type R8.

EgfrE1 mutants exhibit ectopic wing veins.

Heterozygotes have a rough eye phenotype, with elliptical eyes and disarranged ommatidial arrays, and wing vein L2 shows an abnormal broadening at the wing margin.

EgfrE1 heterozygotes exhibit a slight rough eye phenotype.

EgfrE1 mutants exhibit ectopic wing vein formation.

EgfrE1 homozygous adults are small and have greatly reduced numbers of ommatidia with large gaps of pigmented tissue between them. Heterozygous adults have normal eyes.

Heterozygous adults have smaller eyes than normal which have moderate rough phenotype.

EgfrE1/+ flies have rough eyes and a weak extra wing vein phenotype.

Wings of heterozygous and homozygous flies have extra wing vein material.

Heterozygotes have smaller eyes than normal which are mispatterned.

EgfrE1/+ flies have a rough eye phenotype.

Heterozygous mutants do not cause any defects in the ocellar sensory system (OSS) neurogenesis or axon guidance.

Heterozygotes have smaller eyes than normal and lack some ommatidia, producing an irregular arrangement of facets.

Heterozygotes have rough eyes. This phenotype is suppressed towards wild-type in transheterozygous combination with Egfrf24. This phenotype is suppressed towards wild-type in transheterozygous combination with Egfrtsla at 28oC but not at 18oC. Heterozygotes show greatly reduced ommatidial cluster formation in the morphogenetic furrow of the eye disc.

Heterozygotes exhibit roughening of patches on both eyes. Homozygotes exhibit strong blistering, including loss of pigmentation, in patches on both eyes. Rhabdomere assembly is disordered with extra material at the apical ends of the ommatidia. Ommatidia pattern is disordered.

Heterozygotes have rough eyes.

Homozygous flies have a few, widely separated ommatidia. Each ommatidium contains a single R8 cell, as in wild-type flies, and this phenotype is not altered in scaWB1/scaOB7 EgfrE3/EgfrE1 double homozygotes.

Increase the penetrance of extra crossveins in chicgdh-5/EgfrE1 heterozygotes.

Heterozygotes have a mild rough eye phenotype due to a disrupted ommatidial array.

Displays locomotor activity rhythm with an approximately 24h period.

Extra wing veins close to the wing margin.

Mutation has no effect on rhohs.sev rough eye phenotype.

Rough eye phenotype: eyes are small and rough at the perimeter, ommatidia and hairs are in an irregular pattern.

Heterozygous rhove-1 dominantly suppresses the homozygous and heterozygous phenotype. Heterozygous rhoWk, rhoMod and rhoStg enhance the heterozygous phenotype.

Homozygous eye discs have fewer ommatidia than wild-type. Outgrowth of photoreceptor axons is disturbed, occurring in many directions. Cell death is abundant in the region approximately corresponding to columns 10-15 in wild-type. In the adult eye the ommatidia are separated by numerous pigment cells and mechanosensory bristles. Wing veins show thickening and plexus formation. Enhances the wing phenotype of Df(1)N-54l9, N264-39, Dl9P, and DlKX6 mutations, and the eye phenotype of Nspl-1.

Shows a rough eye phenotype in combination with Egfrf6, Egfrf8 or Egfrf10.

Mild roughening of the eye.

Homozygotes have fewer ommatidia than wild-type.

The array of ommatidia is less regular in heterozygotes than in wild-type flies, and there is a slight disturbance in the wing vein pattern. Homozygotes have much smaller eyes than normal, containing many fewer ommatidia, and some regions lack ommatidia entirely. These regions contain cells resembling the pigment cells that normally surround each ommatidium, and also mechanosensory bristles. Most ommatidia contain the normal number and arrangement of cells. Only approximately one tenth of the normal number of preclusters differentiate in the eye imaginal discs.

Eyes of EgfrE1/+ heterozygotes rough and more oval than wild type; also display a slight disturbance of the wing-vein pattern. Homozygotes have smaller eyes with many fewer ommatidia and some regions lack them entirely; those ommatidia that are formed contain the normal number and arrangement of cells; the regions without ommatidia contain cells that resemble pigment cells and mechanosensory bristles; only about one tenth the normal number of preommatidial cell clusters differentiate behind the morphogenetic furrow. EgfrE1 in heterozygous combination with a deficiency or null mutation for Egfr is normal in phenotype indicating that EgfrE1 alleles are hypermorphic.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

EgfrE1 has visible | dominant phenotype, enhanceable by Dhc64C[+]/Dhc64C8-1

EgfrE1 has visible | dominant phenotype, enhanceable by Dhc64C6-10

EgfrE1 has visible | dominant phenotype, enhanceable by Dhc64C6-6

EgfrE1 has visible | dominant phenotype, enhanceable by Dhc64C4-19

EgfrE1 has visible | dominant phenotype, enhanceable by Dhc64C1-1

EgfrE1 has visible | dominant phenotype, enhanceable by Gl[+]/DCTN1-p1501

EgfrE1 has visible | dominant phenotype, enhanceable by Mi-2S047526/Mi-2[+]

EgfrE1 has visible | dominant phenotype, enhanceable by Pp1-87B[+]/Pp1-87Bj6E7

EgfrE1 has visible | dominant phenotype, enhanceable by S[+]/Sk09538a

EgfrE1 has visible | dominant phenotype, enhanceable by hh[+]/hhrJ413

EgfrE1 has visible | dominant phenotype, enhanceable by l(3)06803[+]/l(3)0680306803

EgfrE1 has visible | dominant phenotype, enhanceable by l(3)S001405S001405/l(3)S001405[+]

EgfrE1 has visible | dominant phenotype, enhanceable by l(3)S003704S003704/l(3)S003704[+]

EgfrE1 has visible | dominant phenotype, enhanceable by l(3)S057101[+]/l(3)S057101S057101

EgfrE1 has visible | dominant phenotype, enhanceable by msn[+]/msnj1E2

EgfrE1 has visible | dominant phenotype, enhanceable by px[+]/pxk08316

EgfrE1 has visible | dominant phenotype, enhanceable by scrib[+]/scribj7B3

EgfrE1 has visible | dominant phenotype, enhanceable by spis3547/spi[+]

EgfrE1 has visible | dominant phenotype, enhanceable by twsS049902/tws[+]

EgfrE1 has visible | dominant phenotype, enhanceable by ed[+]/edk01102

EgfrE3/EgfrE1 has visible phenotype, enhanceable by aosW11

EgfrE1 has visible | dominant phenotype, enhanceable by astK6/ast[+]

EgfrE1 has visible | dominant phenotype, enhanceable by vn[+]/vnunspecified

NOT Enhanced by
Statement
Reference

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S023549S023549/l(3)S023549[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S023549S090101/l(3)S023549[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708S023708

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S023901[+]/l(3)S023901S023901

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S024329S024329/l(3)S024329[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S024833[+]/l(3)S024833S024833

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S026238S026238/l(3)S026238[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S026421S026421/l(3)S026421[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S046604S046604/l(3)S046604[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113S056113

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S066607[+]/l(3)S066607S066607

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S068808S068808/l(3)S068808[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S081003S145911/l(3)S081003[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114S090114

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708S092708

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S133117[+]/l(3)S133117S133117

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S135703S135703/l(3)S135703[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S142909S142909/l(3)S142909[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)j4B9j4B9/l(3)j4B9[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)j5B6j5B6/l(3)j5B6[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by neur[+]/neurj6B12

EgfrE1 has visible | dominant phenotype, non-enhanceable by stgS024503/stg[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by Cskj1D8/Csk[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by CycAS054513/CycA[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by DlS049520/Dl[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by Mi-2S005504/Mi-2[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by Mi-2S147412/Mi-2[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by Sin3A[+]/Sin3A08269

EgfrE1 has visible | dominant phenotype, non-enhanceable by crbj1B5/crb[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by drk[+]/drk10626

EgfrE1 has visible | dominant phenotype, non-enhanceable by drk[+]/drkk13809

EgfrE1 has visible | dominant phenotype, non-enhanceable by ebi[+]/ebik16213

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)06906[+]/l(3)0690606906

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S000710[+]/l(3)S000710S000710

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718S000718

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515S009515

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S012805S012805/l(3)S012805[+]

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S016805[+]/l(3)S016805S016805

EgfrE1 has visible | dominant phenotype, non-enhanceable by l(3)S019203S141715/l(3)S019203[+]

Suppressed by
Statement
Reference

EgfrE1 has size defective | dominant phenotype, suppressible by Ptp61F[+]/Ptp61F4-10

EgfrE1 has visible phenotype, suppressible by mir-998exc222

EgfrE1 has visible | dominant phenotype, suppressible by rl[+]/rl1

EgfrE1 has visible | dominant phenotype, suppressible by mago1/mago[+]

EgfrE1 has visible | dominant phenotype, suppressible by Acn27/Acn[+]

EgfrE1 has visible | dominant phenotype, suppressible by Gl[+]/DCTN1-p1501

EgfrE1 has visible | dominant phenotype, suppressible by bonS048706/bon[+]

EgfrE1 has visible | dominant phenotype, suppressible by drkk02401/drk[+]

EgfrE1 has visible | dominant phenotype, suppressible by l(3)j2D5j2D5/l(3)j2D5[+]

EgfrE1 has visible phenotype, suppressible by klu[+]/kluunspecified

EgfrE3/EgfrE1 has visible phenotype, suppressible by aosW11

EgfrE3/EgfrE1 has visible phenotype, suppressible by Nl1N-ts1

EgfrE1 has visible | dominant phenotype, suppressible by cora12

EgfrE1 has visible | dominant phenotype, suppressible by cora15

EgfrE1 has visible | dominant phenotype, suppressible by cora1

EgfrE1 has visible | dominant phenotype, suppressible by cora2

EgfrE1 has visible | dominant phenotype, suppressible by cora13

EgfrE1 has visible | dominant phenotype, suppressible by cora4

EgfrE1 has visible | dominant phenotype, suppressible by cora5

EgfrE1 has visible | dominant phenotype, suppressible by cora6

EgfrE1 has visible | dominant phenotype, suppressible by cora14

EgfrE1 has visible | dominant phenotype, suppressible by cora3

EgfrE1 has visible | dominant phenotype, suppressible by cora7

EgfrE1 has visible | dominant phenotype, suppressible by cora8

EgfrE1 has visible | dominant phenotype, suppressible by cora10

EgfrE1 has visible phenotype, suppressible by Ras85DSutor-341/Ras85D[+]

EgfrE1 has visible phenotype, suppressible by Ras85D[+]/Ras85DSutor-404

EgfrE1 has visible phenotype, suppressible by Sos[+]/SosSutor-157

EgfrE1 has visible phenotype, suppressible by SosSutor-405/Sos[+]

EgfrE1 has visible phenotype, suppressible by Su(tor)1-1[+]/Su(tor)1-1134

EgfrE1 has visible phenotype, suppressible by Su(tor)1-119/Su(tor)1-1[+]

EgfrE1 has visible phenotype, suppressible by Su(tor)2-180[+]/Su(tor)2-1801

EgfrE1 has visible phenotype, suppressible by Su(tor)2-2371/Su(tor)2-237[+]

EgfrE1 has visible phenotype, suppressible by Su(tor)2-278[+]/Su(tor)2-2781

EgfrE1 has visible phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-3211

EgfrE1 has visible phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-31

EgfrE1 has visible phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3361

EgfrE1 has visible phenotype, suppressible by Su(tor)2-4081/Su(tor)2-408[+]

EgfrE1 has visible phenotype, suppressible by Su(tor)3-1[+]/Su(tor)3-138

NOT suppressed by
Statement
Reference

EgfrE1 has visible | dominant phenotype, non-suppressible by Cskj1D8/Csk[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by CycAS054513/CycA[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by DlS049520/Dl[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by Mi-2S005504/Mi-2[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by Mi-2S147412/Mi-2[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by Sin3A[+]/Sin3A08269

EgfrE1 has visible | dominant phenotype, non-suppressible by crbj1B5/crb[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by drk[+]/drk10626

EgfrE1 has visible | dominant phenotype, non-suppressible by drk[+]/drkk13809

EgfrE1 has visible | dominant phenotype, non-suppressible by ebi[+]/ebik16213

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)06906[+]/l(3)0690606906

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S000710[+]/l(3)S000710S000710

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718S000718

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515S009515

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S012805S012805/l(3)S012805[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S016805[+]/l(3)S016805S016805

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S019203S141715/l(3)S019203[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S023549S023549/l(3)S023549[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S023549S090101/l(3)S023549[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708S023708

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S023901[+]/l(3)S023901S023901

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S024329S024329/l(3)S024329[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S024833[+]/l(3)S024833S024833

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S026238S026238/l(3)S026238[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S026421S026421/l(3)S026421[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S046604S046604/l(3)S046604[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113S056113

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S066607[+]/l(3)S066607S066607

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S068808S068808/l(3)S068808[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S081003S145911/l(3)S081003[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114S090114

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708S092708

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S133117[+]/l(3)S133117S133117

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S135703S135703/l(3)S135703[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)S142909S142909/l(3)S142909[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)j4B9j4B9/l(3)j4B9[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by l(3)j5B6j5B6/l(3)j5B6[+]

EgfrE1 has visible | dominant phenotype, non-suppressible by neur[+]/neurj6B12

EgfrE1 has visible | dominant phenotype, non-suppressible by stgS024503/stg[+]

EgfrE1 has visible phenotype, non-suppressible by msk5

EgfrE1 has visible phenotype, non-suppressible by msk4

EgfrE1 has visible | dominant phenotype, non-suppressible by cora11

EgfrE1 has visible | dominant phenotype, non-suppressible by cora9

Enhancer of
Statement
Reference

Egfr[+]/EgfrE1 is an enhancer of visible | heat sensitive phenotype of HC2.hs

NOT Enhancer of
Statement
Reference

EgfrE1 is a non-enhancer of visible phenotype of upd1GMR.PB

Suppressor of
Statement
Reference

EgfrE1 is a suppressor of visible phenotype of PtpmegUAS.cLa, Scer\GAL4en.PU

Egfr[+]/EgfrE1 is a suppressor of visible phenotype of rgγ6

NOT Suppressor of
Statement
Reference

EgfrE1 is a non-suppressor of visible phenotype of upd1GMR.PB

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

EgfrE1 has eye phenotype, enhanceable by Dhc64C[+]/Dhc64C8-1

EgfrE1 has eye phenotype, enhanceable by Gl[+]/DCTN1-p1501

EgfrE1 has eye phenotype, enhanceable by Dhc64C6-10

EgfrE1 has eye phenotype, enhanceable by Dhc64C6-6

EgfrE1 has eye phenotype, enhanceable by Dhc64C4-19

EgfrE1 has eye phenotype, enhanceable by Dhc64C1-1

EgfrE1 has eye phenotype, enhanceable by Mi-2S047526/Mi-2[+]

EgfrE1 has eye phenotype, enhanceable by Pp1-87B[+]/Pp1-87Bj6E7

EgfrE1 has eye phenotype, enhanceable by S[+]/Sk09538a

EgfrE1 has eye phenotype, enhanceable by hh[+]/hhrJ413

EgfrE1 has eye phenotype, enhanceable by l(3)06803[+]/l(3)0680306803

EgfrE1 has eye phenotype, enhanceable by l(3)S001405S001405/l(3)S001405[+]

EgfrE1 has eye phenotype, enhanceable by l(3)S003704S003704/l(3)S003704[+]

EgfrE1 has eye phenotype, enhanceable by l(3)S057101[+]/l(3)S057101S057101

EgfrE1 has eye phenotype, enhanceable by msn[+]/msnj1E2

EgfrE1 has eye phenotype, enhanceable by px[+]/pxk08316

EgfrE1 has eye phenotype, enhanceable by scrib[+]/scribj7B3

EgfrE1 has eye phenotype, enhanceable by spis3547/spi[+]

EgfrE1 has eye phenotype, enhanceable by twsS049902/tws[+]

EgfrE1 has eye phenotype, enhanceable by ed[+]/edk01102

EgfrE1 has phenotype, enhanceable by lilliXS407/lilliXS407

EgfrE1 has phenotype, enhanceable by lillis35

EgfrE1 has phenotype, enhanceable by lilliXS575

EgfrE3/EgfrE1 has wing phenotype, enhanceable by aosW11

EgfrE3/EgfrE1 has wing vein | ectopic phenotype, enhanceable by aosW11

EgfrE1 has eye phenotype, enhanceable by ed1X5

EgfrE1 has eye phenotype, enhanceable by astK6/ast[+]

EgfrE1 has ommatidium phenotype, enhanceable by astK6/ast[+]

EgfrE1 has eye phenotype, enhanceable by vn[+]/vnunspecified

EgfrE1 has ommatidium phenotype, enhanceable by aop[+]/aop1

EgfrE1 has ommatidium phenotype, enhanceable by aop[+]/aop2

EgfrE1 has ommatidium phenotype, enhanceable by aop[+]/aope2d

EgfrE1 has wing vein | ectopic phenotype, enhanceable by rlSem

EgfrE1 has eye phenotype, enhanceable by rl[+]/rlSem

EgfrE1 has eye phenotype, enhanceable by S[+]/S1

EgfrE1 has eye phenotype, enhanceable by Df(2L)ast2

EgfrE1 has phenotype, enhanceable by spi1

EgfrE1 has phenotype, enhanceable by spiSC1

EgfrE1 has phenotype, enhanceable by spiSC2

EgfrE1 has phenotype, enhanceable by spiSC3

NOT Enhanced by
Statement
Reference

EgfrE1 has eye phenotype, non-enhanceable by Cskj1D8/Csk[+]

EgfrE1 has eye phenotype, non-enhanceable by CycAS054513/CycA[+]

EgfrE1 has eye phenotype, non-enhanceable by DlS049520/Dl[+]

EgfrE1 has eye phenotype, non-enhanceable by Mi-2S005504/Mi-2[+]

EgfrE1 has eye phenotype, non-enhanceable by Mi-2S147412/Mi-2[+]

EgfrE1 has eye phenotype, non-enhanceable by Sin3A[+]/Sin3A08269

EgfrE1 has eye phenotype, non-enhanceable by crbj1B5/crb[+]

EgfrE1 has eye phenotype, non-enhanceable by drk[+]/drk10626

EgfrE1 has eye phenotype, non-enhanceable by drk[+]/drkk13809

EgfrE1 has eye phenotype, non-enhanceable by ebi[+]/ebik16213

EgfrE1 has eye phenotype, non-enhanceable by l(3)06906[+]/l(3)0690606906

EgfrE1 has eye phenotype, non-enhanceable by l(3)S000710[+]/l(3)S000710S000710

EgfrE1 has eye phenotype, non-enhanceable by l(3)S000718[+]/l(3)S000718S000718

EgfrE1 has eye phenotype, non-enhanceable by l(3)S009515[+]/l(3)S009515S009515

EgfrE1 has eye phenotype, non-enhanceable by l(3)S012805S012805/l(3)S012805[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S016805[+]/l(3)S016805S016805

EgfrE1 has eye phenotype, non-enhanceable by l(3)S019203S141715/l(3)S019203[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S023549S023549/l(3)S023549[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S023549S090101/l(3)S023549[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708S023708

EgfrE1 has eye phenotype, non-enhanceable by l(3)S023901[+]/l(3)S023901S023901

EgfrE1 has eye phenotype, non-enhanceable by l(3)S024329S024329/l(3)S024329[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S024833[+]/l(3)S024833S024833

EgfrE1 has eye phenotype, non-enhanceable by l(3)S026238S026238/l(3)S026238[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S026421S026421/l(3)S026421[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S046604S046604/l(3)S046604[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S056113[+]/l(3)S056113S056113

EgfrE1 has eye phenotype, non-enhanceable by l(3)S066607[+]/l(3)S066607S066607

EgfrE1 has eye phenotype, non-enhanceable by l(3)S068808S068808/l(3)S068808[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S081003S145911/l(3)S081003[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S090114[+]/l(3)S090114S090114

EgfrE1 has eye phenotype, non-enhanceable by l(3)S092708[+]/l(3)S092708S092708

EgfrE1 has eye phenotype, non-enhanceable by l(3)S133117[+]/l(3)S133117S133117

EgfrE1 has eye phenotype, non-enhanceable by l(3)S135703S135703/l(3)S135703[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)S142909S142909/l(3)S142909[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)j4B9j4B9/l(3)j4B9[+]

EgfrE1 has eye phenotype, non-enhanceable by l(3)j5B6j5B6/l(3)j5B6[+]

EgfrE1 has eye phenotype, non-enhanceable by neur[+]/neurj6B12

EgfrE1 has eye phenotype, non-enhanceable by stgS024503/stg[+]

Suppressed by
Statement
Reference

EgfrE1 has eye phenotype, suppressible by Ptp61F[+]/Ptp61F4-10

EgfrE1 has eye phenotype, suppressible by mir-998exc222

EgfrE1 has wing vein phenotype, suppressible by Hsp83e6D

EgfrE1 has wing vein | ectopic phenotype, suppressible by rl[+]/rl1

EgfrE1 has wing vein | ectopic phenotype, suppressible by mago1/mago[+]

EgfrE1 has eye phenotype, suppressible by Acn27/Acn[+]

EgfrE1 has wing vein L2 phenotype, suppressible by Gl[+]/DCTN1-p1501

EgfrE1 has eye phenotype, suppressible by bonS048706/bon[+]

EgfrE1 has eye phenotype, suppressible by drkk02401/drk[+]

EgfrE1 has eye phenotype, suppressible by l(3)j2D5j2D5/l(3)j2D5[+]

EgfrE1 has ommatidium phenotype, suppressible by klu[+]/kluunspecified

EgfrE1 has wing vein | ectopic phenotype, suppressible by Rafunspecified

EgfrE1 has wing vein | ectopic phenotype, suppressible by Stat92Eunspecified/Stat92E[+]

EgfrE1 has wing vein | ectopic phenotype, suppressible by Ras85D[+]/Ras85Dunspecified

EgfrE3/EgfrE1 has eye phenotype, suppressible by aosW11

EgfrE3/EgfrE1 has eye phenotype, suppressible by Nl1N-ts1

EgfrE1 has eye phenotype, suppressible by cora2

EgfrE1 has eye phenotype, suppressible by cora12

EgfrE1 has eye phenotype, suppressible by cora15

EgfrE1 has eye phenotype, suppressible by cora1

EgfrE1 has eye phenotype, suppressible by cora13

EgfrE1 has eye phenotype, suppressible by cora4

EgfrE1 has eye phenotype, suppressible by cora5

EgfrE1 has eye phenotype, suppressible by cora6

EgfrE1 has eye phenotype, suppressible by cora14

EgfrE1 has eye phenotype, suppressible by cora3

EgfrE1 has eye phenotype, suppressible by cora7

EgfrE1 has eye phenotype, suppressible by cora8

EgfrE1 has eye phenotype, suppressible by cora10

EgfrE1 has phenotype, suppressible by SoseCN6

EgfrE1 has phenotype, suppressible by SoseCS3

EgfrE1 has phenotype, suppressible by SoseDN4

EgfrE1 has phenotype, suppressible by SoseJ2

EgfrE1 has phenotype, suppressible by SoseN6

EgfrE1 has eye phenotype, suppressible | partially by cora[+]/cora1

EgfrE1 has eye phenotype, suppressible by Ras85DSutor-341/Ras85D[+]

EgfrE1 has eye phenotype, suppressible by Ras85D[+]/Ras85DSutor-404

EgfrE1 has eye phenotype, suppressible by Sos[+]/SosSutor-157

EgfrE1 has eye phenotype, suppressible by SosSutor-405/Sos[+]

EgfrE1 has eye phenotype, suppressible by Su(tor)1-1[+]/Su(tor)1-1134

EgfrE1 has eye phenotype, suppressible by Su(tor)1-119/Su(tor)1-1[+]

EgfrE1 has eye phenotype, suppressible by Su(tor)2-180[+]/Su(tor)2-1801

EgfrE1 has eye phenotype, suppressible by Su(tor)2-2371/Su(tor)2-237[+]

EgfrE1 has eye phenotype, suppressible by Su(tor)2-278[+]/Su(tor)2-2781

EgfrE1 has eye phenotype, suppressible by Su(tor)2-321[+]/Su(tor)2-3211

EgfrE1 has eye phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-31

EgfrE1 has eye phenotype, suppressible by Su(tor)2-3[+]/Su(tor)2-3361

EgfrE1 has eye phenotype, suppressible by Su(tor)2-4081/Su(tor)2-408[+]

EgfrE1 has eye phenotype, suppressible by Su(tor)3-1[+]/Su(tor)3-138

NOT suppressed by
Statement
Reference

EgfrE1 has wing vein phenotype, non-suppressible by Ero1L[+]/Ero1L23T

EgfrE1 has eye phenotype, non-suppressible by Cskj1D8/Csk[+]

EgfrE1 has eye phenotype, non-suppressible by CycAS054513/CycA[+]

EgfrE1 has eye phenotype, non-suppressible by DlS049520/Dl[+]

EgfrE1 has eye phenotype, non-suppressible by Mi-2S005504/Mi-2[+]

EgfrE1 has eye phenotype, non-suppressible by Mi-2S147412/Mi-2[+]

EgfrE1 has eye phenotype, non-suppressible by Sin3A[+]/Sin3A08269

EgfrE1 has eye phenotype, non-suppressible by crbj1B5/crb[+]

EgfrE1 has eye phenotype, non-suppressible by drk[+]/drk10626

EgfrE1 has eye phenotype, non-suppressible by drk[+]/drkk13809

EgfrE1 has eye phenotype, non-suppressible by ebi[+]/ebik16213

EgfrE1 has eye phenotype, non-suppressible by l(3)06906[+]/l(3)0690606906

EgfrE1 has eye phenotype, non-suppressible by l(3)S000710[+]/l(3)S000710S000710

EgfrE1 has eye phenotype, non-suppressible by l(3)S000718[+]/l(3)S000718S000718

EgfrE1 has eye phenotype, non-suppressible by l(3)S009515[+]/l(3)S009515S009515

EgfrE1 has eye phenotype, non-suppressible by l(3)S012805S012805/l(3)S012805[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S016805[+]/l(3)S016805S016805

EgfrE1 has eye phenotype, non-suppressible by l(3)S019203S141715/l(3)S019203[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S023549S023549/l(3)S023549[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S023549S090101/l(3)S023549[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708S023708

EgfrE1 has eye phenotype, non-suppressible by l(3)S023901[+]/l(3)S023901S023901

EgfrE1 has eye phenotype, non-suppressible by l(3)S024329S024329/l(3)S024329[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S024833[+]/l(3)S024833S024833

EgfrE1 has eye phenotype, non-suppressible by l(3)S026238S026238/l(3)S026238[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S026421S026421/l(3)S026421[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S046604S046604/l(3)S046604[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S056113[+]/l(3)S056113S056113

EgfrE1 has eye phenotype, non-suppressible by l(3)S066607[+]/l(3)S066607S066607

EgfrE1 has eye phenotype, non-suppressible by l(3)S068808S068808/l(3)S068808[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S081003S145911/l(3)S081003[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S090114[+]/l(3)S090114S090114

EgfrE1 has eye phenotype, non-suppressible by l(3)S092708[+]/l(3)S092708S092708

EgfrE1 has eye phenotype, non-suppressible by l(3)S133117[+]/l(3)S133117S133117

EgfrE1 has eye phenotype, non-suppressible by l(3)S135703S135703/l(3)S135703[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)S142909S142909/l(3)S142909[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)j4B9j4B9/l(3)j4B9[+]

EgfrE1 has eye phenotype, non-suppressible by l(3)j5B6j5B6/l(3)j5B6[+]

EgfrE1 has eye phenotype, non-suppressible by neur[+]/neurj6B12

EgfrE1 has eye phenotype, non-suppressible by stgS024503/stg[+]

EgfrE1 has wing vein | ectopic phenotype, non-suppressible by Mad[+]/Madunspecified

EgfrE1 has wing vein | ectopic phenotype, non-suppressible by tkvunspecified/tkv[+]

EgfrE1 has wing vein | ectopic phenotype, non-suppressible by msk4

EgfrE1 has wing vein | ectopic phenotype, non-suppressible by msk5

EgfrE1 has eye phenotype, non-suppressible by cora11

EgfrE1 has eye phenotype, non-suppressible by cora9

Enhancer of
Statement
Reference

Egfr[+]/EgfrE1 is an enhancer of wing vein | ectopic phenotype of Snr1E1

Egfr[+]/EgfrE1 is an enhancer of wing vein | ectopic | heat sensitive phenotype of HC2.hs

Egfr[+]/EgfrE1 is an enhancer of wing | heat sensitive phenotype of HC2.hs

Egfr[+]/EgfrE1 is an enhancer of wing vein L1 phenotype of Adv1

Egfr[+]/EgfrE1 is an enhancer of wing vein L2 phenotype of Adv1

Egfr[+]/EgfrE1 is an enhancer of wing vein | ectopic phenotype of Adv1

Egfr[+]/EgfrE1 is an enhancer of eye phenotype of S1

NOT Enhancer of
Statement
Reference

EgfrE1 is a non-enhancer of eye phenotype of upd1GMR.PB

EgfrE1 is a non-enhancer of phenotype of DoaHD/DoaDem

EgfrE1 is a non-enhancer of phenotype of Rho1rev220

Suppressor of
Statement
Reference

EgfrE1 is a suppressor of wing vein phenotype of PtpmegUAS.cLa, Scer\GAL4en.PU

Egfr[+]/EgfrE1 is a suppressor of eye phenotype of rgγ6

EgfrE1 is a suppressor of eye phenotype of hidGMR.PG/WGMR.PG

EgfrE1 is a suppressor of ommatidium phenotype of hidGMR.PG/WGMR.PG

EgfrE1 is a suppressor of phenotype of vnddd-13

EgfrE1 is a suppressor of wing disc phenotype of Df(3L)γ3/vnγ4

EgfrE1 is a suppressor of phenotype of vnL6

NOT Suppressor of
Statement
Reference

EgfrE1 is a non-suppressor of eye phenotype of upd1GMR.PB

EgfrE1 is a non-suppressor of phenotype of DoaHD/DoaDem

EgfrE1 is a non-suppressor of phenotype of Rho1rev220

Other
Additional Comments
Genetic Interactions
Statement
Reference

EgfrE1 suppresses the wing vein loss seen when PtpmegScer\UAS.cLa is expressed under the control of Scer\GAL4en.PU.

mir-998exc222 strongly suppresses the reduction in ommatidial cluster number and rough eye phenotype seen in EgfrE1/+ mutant eye discs. When mir-998exc222 mutant clones are induced in EgfrE1 eye discs, the mutant phenotype is partially suppressed in cells immediately adjacent to the clones, suggesting non-cell autonomous effects.

Expression of CG4096KK108644 under the control of Scer\GAL4Act5C.PU enhances the extra wing vein phenotype of EgfrE1 flies.

Expression of Sulf1Scer\UAS.cBa under the control of Scer\GAL4Act5C.PU suppresses the extra wing vein phenotype of EgfrE1 flies.

A Hsp83e6D background suppresses the abnormal wing vein morphology found in EgfrE1 heterozygous flies.

The extra wing vein phenotype seen in EgfrE1/+ flies is dominantly suppressed by rl1 or mago1.

The rough eye phenotype of EgfrE1/+ flies is suppressed by Acn27/+.

In EgfrE1/+ adults, the number of ommatidia with pale-type R8 cells and yellow-type R7 cells is significantly increased. Many of these are found in pale-yellow hybrid ommatidia with a yellow-type R7 and a pale-type R8. This phenotype is suppressed by sev14/sev14, but not by rhoPΔ5 homozygous somatic clones.

Dhc64C8-1 dominantly enhances the eye phenotype of EgfrE1/+ flies, resulting in a reduced, narrower eye with fewer ommatidia.

The abnormal broadening of wing vein L2 at the wing margin which is seen in EgfrE1/+ flies is suppressed by Gl1/+.

An EgfrE1 heterozygous background gives a dominant enhancement to the ato1090/Df(3R)p13 eye phenotype at 25[o]C.

A Ero1L23T heterozygous background does not affect the ectopic wing vein formation phenotype found in EgfrE1 homozygous mutants.

Adult eyes containing sensE2 homozygous somatic clones induced in an EgfrE1/+ background are smaller than wild-type. Within the clone there are reduced numbers of ommatidia, as well as gaps of tissue between ommatidia, a phenotype similar to that seen in EgfrE1 homozygotes. sensScer\UAS.cNa; Scer\GAL4ey.PB partially rescues eye size and ommatidial number, and completely suppresses the formation of undifferentiated regions in EgfrE1 homozygous adult eyes.

EgfrE1/+ enhances the formation of an ectopic crossvein in flies expressing Pi3K68DKD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL469B at 25[o]C.

Flies expressing Pi3K68DScer\UAS.T:Hsap\MYC under the control of Scer\GAL469B in a EgfrE1/+ background at 25[o]C show loss of the anterior and partial loss of the posterior crossvein.

kluunspecified/+ suppresses the rough eye phenotype seen in EgfrE1 adults.

The rough eye phenotype of EgfrE1/+ flies is strongly enhanced by homozygosity for kek1unspecified. These flies also have small eyes and more extra vein material than EgfrE1/+ flies.

edk01102/+ strongly enhances the EgfrE1/+ phenotype, resulting in eyes that are approximately 1/3 the size of those of EgfrE1/+ flies.

EgfrE1/+ flies carrying Pp2B-14Dact.GMR and CanBGMR.PS have a rough eye phenotype similar to that caused by Pp2B-14Dact.GMR and CanBGMR.PS in an Egfr+ background.

The number of ommatidia in the eyes of EgfrE1/EgfrE3 adults is not altered if the flies are also expressing BacA\p35GMR.PH, but the number of pigment cells is increased in these animals.

Expression of p38bDN.Scer\UAS under the control of Scer\GAL4unspecified has no significant effect on the wing phenotype caused by EgfrE1.

R8 photoreceptor cells fail to form in EgfrE1/+ ; 14-3-3εj2B10/Df(3R)P14 eye discs.

argosW11 enhances the extra wing vein phenotype of EgfrE1/EgfrE3 transheterozygotes but suppresses the eye phenotype. Nl1N-ts1 also suppresses the eye phenotype of EgfrE1/EgfrE3.

The eye phenotype of EgfrE1 heterozygotes is dominantly enhanced by astK6.

The EgfrE1/+ rough eye phenotype is completely suppressed by cora12 or cora15. The EgfrE1/+ phenotype is partially suppressed by cora1, cora2 or cora13; the eye is wild type in size with some roughening. The EgfrE1/+ phenotype is partially suppressed by cora4, cora5, cora6 or cora14; the eye is smaller than wild type with some roughening. The EgfrE1/+ rough eye phenotype is slightly suppressed by cora3, cora7, cora8 or cora10. The EgfrE1/+ rough eye phenotype is not dominantly suppressed by cora9 or cora11.

The EgfrE1/+ rough eye phenotype is strongly dominantly enhanced by vnunspecified.

Suppresses the viability of vnddd-13, the proliferation defects in vnL6 and (partially) the small disc phenotype of vnγ4.

Introduction of one copy of aope2d significantly enhances the EgfrE1/+ phenotype, eyes are severely defective, reduced in size and very rough. aop1 and aop2 give a similar enhancement of the mutant eye phenotype.

The heterozygous extra wing vein phenotype is enhanced when transheterozygous with rlSem. Flies heterozygous for EgfrE1 and rlSem have smaller eyes than EgfrE1 heterozygotes alone.

Eye of double heterozygotes with S1 are dramatically reduced with respect to those of either heterozygote alone. When heterozygous for Df(2L)ast2 (removing S and ast) the reduced phenotype becomes much more pronounced.

Eye phenotype can be suppressed by mutations of spi.

Phenotype is suppressed by loss of function Sos alleles but enhanced by SosJC2.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (12)
Notes on Origin
Discoverer

E.H. Grell, Feb. 1957.

Comments
Comments

Phenotype is highly sensitive to the wild-type genetic background.

Mutations in S suppress the formation of ectopic wing veins in EgfrE1 flies, but enhance the mutant phenotype in the eye.

Rough eye phenotype is dominantly suppressed by cora1 and cora2.

External Crossreferences and Linkouts ( 5 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
Synonyms and Secondary IDs (22)
Reported As
Symbol Synonym
dEGFREllipse(B1)
Secondary FlyBase IDs
    References (90)