FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fs(1)h4
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General Information
Symbol
Dmel\fs(1)h4
Species
D. melanogaster
Name
FlyBase ID
FBal0004281
Feature type
allele
Associated gene
Dmel\fs(1)h
Associated Insertion(s)
Carried in Construct
Also Known As
fsh4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
diepoxybutane
(Digan et al., 1986)
Progenitor genotype
Cytology
Description

Insertion of approximately 8kb between map positions 38.4 and 38.9 (the origin of molecular coordinates is a SacI site just proximal to the proximal breakpoint of Df(1)C128, positive values to the left).

(Digan et al., 1986)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fs(1)h4/fs(1)h1 females are fertile at 18[o]C, but lose fertility at 26.5[o]C.

      Approximately 50% of progeny from fs(1)h4/fs(1)h1 mothers, raised at semipermissive temperatures (22[o]C), do not survive embryogenesis. Cuticle analysis reveals a weak pair-rule phenotype, which is most consistently observed in even parasegments. 75% of defects seen involve the second abdominal segment.

      (Florence and Faller, 2008)

      Mutation does not affect the level of w expression in ph-plac+3 flies.

      (Fauvarque et al., 1995)

      Females heterozygous for fs(1)h4 that also carry Df(3R)red-P93 give rise to progeny with a high frequency of homeotic transformation of T3 to T2.

      (Digan et al., 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      fs(1)h4, trx[+]/trxE2 has visible phenotype

      (Florence and Faller, 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      21% of fs(1)h4/+;trxE2/+ adults show segmental deletions, and 41% show transformations of haltere to wing and T1 or T3 leg and plura to T2 identity.

      (Florence and Faller, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Relative strengths of the mutant alleles estimated as follows: Df(1)C128 = fs(1)h5 = fs(1)h4 > fs(1)h18 > fs(1)h3 > fs(1)h8 > fs(1)h17 > fs(1)h2 > fs(1)h6 > fs(1)h1.

      Relative strengths of the mutant alleles estimated as follows: fs(1)h2 > fs(1)h6 > fs(1)h1 for the temperature sensitive alleles, Df(1)C128 = fs(1)h5 = fs(1)h4 > fs(1)h18 > fs(1)h3 > fs(1)h8 > fs(1)h17 for the non-conditional alleles. for the non-conditional alleles.

      (Digan et al., 1986)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fs(1)h4
      (Popodi et al., 2010-)
      fs(1)h4
      (Florence and Faller, 2008)
      fsh4
      (Haynes et al., 1989, Digan et al., 1986)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)