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General Information
Symbol
Dmel\fz1
Species
D. melanogaster
Name
FlyBase ID
FBal0004917
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

macrochaeta & adult abdomen | somatic clone | cell non-autonomous

microchaeta & adult abdomen | somatic clone | cell non-autonomous

microchaeta & adult thorax | somatic clone | cell non-autonomous

wing & macrochaeta

Detailed Description
Statement
Reference

Mutant embryos show salivary gland guidance defects; a large portion of the salivary gland curves towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.

When mutant clones are made in the developing eye, no R-cell precursor nuclear migration phenotype was seen.

Bristles and hairs on the adult abdomen and thorax show altered polarity. Clones reveal the effect shows domineering non-autonomy. fz1 phenotypes differ from in1 and fy1 in two ways. In fz1 the hairs on the scutellum show a complicated pattern rather than pointing anteriorly, and thorax microchaetae are not routinely split. On the leg, femoral bracts are mispositioned indicating abnormal polarity. Tarsal segments may have parts missing and/or duplicated and show cuticular blebs. Eyes show a rough eye phenotype due to ommatidial disorganisation. Pupal wings show miseversion phenotype - many pupae show an everting wing oriented anteriorly and sometimes dorsally.

Embryos lacking maternal and zygotic fz function (derived from a cross between fz1/fz30 males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 10% of cases. Embryos lacking maternal and zygotic fz function (derived from a cross between fz1/fz23 males and females) are missing the RP2/sib lineage in 1-2 hemisegments in 11% of cases.

Homozygous embryos derived from homozygous females have a negligible segment-polarity phenotype. Injection of dsRNA produced by annealing fz2L.cKa and fz2a.L.cKa RNA into these embryos results in segment polarity phenotypes.

Bristle polarity phenotype.

moderate thoracic bristle phenotype moderate wing-hair disorientation

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

fz1/fz1 is a non-enhancer of visible | adult stage phenotype of in1

fz1/fz1 is a non-enhancer of abnormal planar polarity | adult stage phenotype of in1

fz1/fz1 is a non-enhancer of visible | adult stage phenotype of frtz30

fz1/fz1 is a non-enhancer of visible | adult stage phenotype of fy2

fz1/fz1 is a non-enhancer of abnormal planar polarity | adult stage phenotype of fy2

fz1 is a non-enhancer of abnormal neuroanatomy | embryonic stage phenotype of mud3

NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

fz1 has bract phenotype, non-enhanceable by fy1

fz1 has leg joint phenotype, non-enhanceable by fy1

fz1 has tarsal segment phenotype, non-enhanceable by fy1

fz1 has bract phenotype, non-enhanceable by in1

fz1 has leg joint phenotype, non-enhanceable by in1

fz1 has tarsal segment phenotype, non-enhanceable by in1

Suppressed by
Statement
Reference

fz1 has wing disc | P-stage phenotype, suppressible by in1

fz1 has wing disc | P-stage phenotype, suppressible by fy1

NOT suppressed by
Statement
Reference

fz1 has eye phenotype, non-suppressible by in1

fz1 has leg joint phenotype, non-suppressible by in1

fz1 has ommatidium phenotype, non-suppressible by in1

fz1 has tarsal segment phenotype, non-suppressible by in1

fz1 has microchaeta & adult thorax | somatic clone | cell non-autonomous phenotype, non-suppressible by in1

fz1 has bract phenotype, non-suppressible by fy1

fz1 has eye phenotype, non-suppressible by fy1

fz1 has leg joint phenotype, non-suppressible by fy1

fz1 has ommatidium phenotype, non-suppressible by fy1

fz1 has tarsal segment phenotype, non-suppressible by fy1

fz1 has bract phenotype, non-suppressible by in1

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

fz1 is a non-suppressor of microchaeta & adult thorax phenotype of in1

fz1 is a non-suppressor of microchaeta & adult thorax phenotype of fy1

fz1 is a non-suppressor of ommatidium phenotype of Rac1V12.hs.sev

Other
Additional Comments
Genetic Interactions
Statement
Reference

fy2;fz1 double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in fy2 single mutants and the severity of abdominal bristle polarity phenotype in1,fz1 double mutant is similar to in single mutants. The frtz30;fz1 double mutant have abdominal bristle defects that are comparable to frtz30 single mutants.

fz1, Df(1)NetABΔ double mutant embryos display a severe lack of commissures in the ventral nerve cord.

fz1, mud3 mutant embryos do not display any more severe ventral nerve cord phenotypes, as compared to each single mutant.

drlR343 ; fz1 double mutants have a higher penetrance of salivary gland curving than is seen in either of the single mutants alone.

Domineering non-autonomy of fz1 clones is not suppressed by in1. Leg phenotypes of fz1 and fy1 or in1 are additive.

ParpGMR.PU shows no genetic interaction with fz1/+.

All fz1/fz1; Df(3L)N2-27 double mutant embryos show RP2/sib lineage defects, with 6-11 hemisegments per embryo being affected.

In double mutant combinations between VangA3, VangA5 and VangTbs42 with fz1, fz25 and fz30, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

fz1 somatic clones in the eye in a fzsevE3.SevP.PS background: In the center of clones, 15%-25% of ommatidia showed dorso-ventral inversions, as observed in eyes wholly mutant for fz in a fzsevE3.SevP.PS background. However, on the polar edge of the clone, 40%-60% of ommatidia are inverted, whereas, on the equatorial edge, only 5% are inverted. These inversions are also seen on outside the clone, near its polar boundary.

Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer

Bridges, 18th Feb. 1938.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (31)