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General Information
Symbol
Dmel\cacHC129
Species
D. melanogaster
Name
FlyBase ID
FBal0006138
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(1)L13HC129
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In CNS-removed larvae that are both mutant for cacHC129 and express cacRQ.UAS.EGFP under the control of Scer\GAL4elav-C155, 30 presynaptic pulses lead to NMJ EPSP profiles with shoulders.

cacHC129 mutant embryos exhibit normal amplitude mEJPs but severely reduced synaptic transmission. No evoked response can be detected in 1mM Ca[2+] Saline, compared to an average response of over 1nA in wild-type embryos.

cacHC129 mutant embryos develop boutons and exhibit normal Ank2 localisation.

Song pulse amplitude in heterozygotes with cac1 is higher than wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Statement
Reference

cacHC129 has viable phenotype, suppressible by Frq2[+]/Frq2f06131

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Enhancer of
NOT Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for cacHC129 significantly suppresses the increase in evoked excitatory junctional potential currents (EJCs) and quantal content (QC) in homozygous Df(2R)KT40 mutants.

Flies trans-heterozygous for Frq2f06131 and cacHC129 exhibit a 50% reduction in viability.

There is a significant reduction in EJP amplitude in Df(X)frqdel1/cacHC129 larvae compared to controls. mEJP frequency and amplitudes are not significantly different.

The presence of the heterozygous cacHC129/+ mutation has little effect on the quantal content in a homozygous GluRIIASP16 background.

The recessive GluRIIASP16 single mutant NMJ synaptic homeostatic response is completely suppressed in the presence of a heterozygous cacHC129/+ mutation in combination with an Exnunspecified/+ heterozygous genetic background.

Xenogenetic Interactions
Statement
Reference

cacHC129/+ significantly suppresses the increased excitatory junction potential (EJP) amplitude and decreased failure rate seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4elav-C155 animals at 0.25 mM Ca[2+].

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Lefevre.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (17)