cacHC129 mutant embryos exhibit normal amplitude mEJPs but severely reduced synaptic transmission. No evoked response can be detected in 1mM Ca[2+] Saline, compared to an average response of over 1nA in wild-type embryos.
cacHC129 mutant embryos develop boutons and exhibit normal Ank2 localisation.
The presence of the heterozygous cacHC129/+ mutation has little effect on the quantal content in a homozygous GluRIIASP16 background.
The recessive GluRIIASP16 single mutant NMJ synaptic homeostatic response is completely suppressed in the presence of a heterozygous cacHC129/+ mutation in combination with an Exnunspecified/+ heterozygous genetic background.