FlyBase Allele Report: Dmel\dally[06464]

The ovarioles of dally⁰⁶⁴⁶⁴/dally⁸⁰ females show progressive loss of the germline stem cells (GSCs), with 59% of ovarioles containing no GSCs in the niche at day 10 after eclosion.

(Guo and Wang, 2009)

Wings of homozygous adults are smaller than normal, primarily due to a reduction in cell number rather than cell size.

(Eugster et al., 2007)

dally⁰⁶⁴⁶⁴ mutants display ISNb bypass at a similar rate to wild-type embryos.

(Fox and Zinn, 2005)

Homozygotes have rough eyes, a reduced antenna, incomplete wing vein 5 and reduced genitalia, with incomplete penetrance. The ability of the lamina precursor neurons to enter a second division cycle is reduced in homozygous larvae.

(Nakato et al., 2002)

The number of the multiply innervated (recurved) bristles in the dorsal row of dally⁰⁶⁴⁶⁴/dally^gem wings decreases to 55% of that of wild-type flies. Homozygotes exhibit defects the formation of macrochaetae. They lack anterior dorsocentral (aDC) and posterior supralar (pSA) bristles. the posterior dorsocentral (pDC) is displaced anteriorly or forms at an intermediate position between the aDC and pDC. Homozygotes also defects in microchaetae. Numbers are reduced and occur irregularly. In dally^gem/dally⁰⁶⁴⁶⁴ flies, 86% of animals lack the posterior supraalar bristle (pSA), 24% the anterior dorsocentral bristles (aDC) and 1% the posterior supraalar bristle (pSA).

(Fujise et al., 2001)

3% of homozygous dally⁰⁶⁴⁶⁴ flies exhibit a wing notching phenotype.

(Lin and Perrimon, 1999)

dally^ΔP-527/dally⁰⁶⁴⁶⁴ mutant embryos show a loss of naked cuticle and abnormalities with segment polarity (21% penetrance). About 70% of dally⁰⁶⁴⁶⁴/dally^gem flies show abnormalities in their genitalia.

(Tsuda et al., 1999)

Semilethal. Reduction or complete loss of genitalia, disordering and reduction in the number of ommatidia, reductions and duplications of the antenna and incomplete wing vein V and wing notching. Disruptions in the cell cycle progression of lamina precursors and of G₂-M progression in the eye disc.

(Nakato et al., 1995)

Homozygotes have wing vein defect.

(Berkeley Drosophila Genome Project, 1993.6.1)

some visible defects in eyes, wing veins, genitalia, male sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dally⁰⁶⁴⁶⁴ has visible | recessive phenotype, enhanceable by wg[+]/wg^l-8

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has visible | recessive phenotype, enhanceable by dpp^d-blk/dpp[+]

(Jackson et al., 1997)

dally⁰⁶⁴⁶⁴ has visible | recessive phenotype, enhanceable by dpp^d14/dpp[+]

(Jackson et al., 1997)

NOT Enhanced by

Statement

Reference

dally⁰⁶⁴⁶⁴ has partially lethal phenotype, non-enhanceable by Df(2R)59AB/+

(Nakato et al., 2002)

Suppressed by

Statement

Reference

dally⁸⁰/dally⁰⁶⁴⁶⁴ has abnormal cell number | oogenesis phenotype, suppressible by Scer\GAL4^C587/dpp^UAS.cUa.GFP

(Liu et al., 2024)

dally⁸⁰/dally⁰⁶⁴⁶⁴ has abnormal cell number | oogenesis phenotype, suppressible by Scer\GAL4^nanos.PG/Kr^UASz.Tag:HA

(Liu et al., 2024)

dally⁰⁶⁴⁶⁴ has visible phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has visible phenotype, suppressible by CycA[+]/CycA⁵

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has partially lethal phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has partially lethal phenotype, suppressible by CycA[+]/CycA⁵

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has visible | recessive phenotype, suppressible by dpp^d14/dpp[+]

(Jackson et al., 1997)

NOT suppressed by

Statement

Reference

dally⁰⁶⁴⁶⁴ has partially lethal phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

Enhancer of

Statement

Reference

dally⁰⁶⁴⁶⁴ is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, fz2^UAS.N

(Lin and Perrimon, 1999)

NOT Enhancer of

Statement

Reference

dally[+]/dally⁰⁶⁴⁶⁴ is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

dally[+]/dally⁰⁶⁴⁶⁴ is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Suppressor of

Statement

Reference

dally⁰⁶⁴⁶⁴ is a suppressor of visible phenotype of Scer\GAL4^69B, fz2^UAS.cCa

(Lin and Perrimon, 1999)

NOT Suppressor of

Statement

Reference

dally[+]/dally⁰⁶⁴⁶⁴ is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

dally[+]/dally⁰⁶⁴⁶⁴ is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Other

Statement

Reference

Scer\GAL4^tj.PU, dally⁸⁰/dally⁰⁶⁴⁶⁴, tsl^UAS.cSa has abnormal cell number | oogenesis phenotype

(Liu et al., 2024)

Scer\GAL4^nanos.PG, dally⁸⁰/dally⁰⁶⁴⁶⁴, tll^{UAS.ORF.GW.Tag:HA} has abnormal cell number | oogenesis phenotype

(Liu et al., 2024)

Kr^KK105429, Scer\GAL4^nanos.PG, dally⁸⁰/dally⁰⁶⁴⁶⁴ has abnormal cell number | oogenesis phenotype

(Liu et al., 2024)

dally⁰⁶⁴⁶⁴, dpp^d-blk/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has visible | dominant phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has visible | dominant phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has visible | dominant phenotype

(Jackson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

dally^gem/dally⁰⁶⁴⁶⁴ has anterior dorsocentral bristle phenotype, enhanceable by put¹⁰⁴⁶⁰

(Fujise et al., 2001)

dally^gem/dally⁰⁶⁴⁶⁴ has posterior supraalar bristle phenotype, enhanceable by put¹⁰⁴⁶⁰

(Fujise et al., 2001)

dally^gem/dally⁰⁶⁴⁶⁴ has posterior supraalar bristle phenotype, enhanceable by wg^l-17

(Fujise et al., 2001)

dally⁰⁶⁴⁶⁴ has wing phenotype, enhanceable by wg[+]/wg^l-8

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has wing margin bristle phenotype, enhanceable by wg[+]/wg^l-8

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has phenotype, enhanceable by wg[+]/wg^unspecified

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has embryo | segment polarity expression pattern | germline clone phenotype, enhanceable by wg[+]/wg^unspecified

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has embryo | segment polarity expression pattern | germline clone phenotype, enhanceable by sfl[+]/sfl^unspecified

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has embryonic epidermis | germline clone phenotype, enhanceable by sfl[+]/sfl^unspecified

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has eye phenotype, enhanceable by dpp^d-blk/dpp[+]

(Jackson et al., 1997)

dally⁰⁶⁴⁶⁴ has eye phenotype, enhanceable by dpp^d14/dpp[+]

(Jackson et al., 1997)

dally⁰⁶⁴⁶⁴ has antenna phenotype, enhanceable by dpp^d14/dpp[+]

(Jackson et al., 1997)

dally⁰⁶⁴⁶⁴ has genitalia phenotype, enhanceable by dpp^d14/dpp[+]

(Jackson et al., 1997)

NOT Enhanced by

Statement

Reference

dally⁰⁶⁴⁶⁴ has antenna phenotype, non-enhanceable by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has genitalia phenotype, non-enhanceable by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has ommatidium phenotype, non-enhanceable by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has wing vein L5 phenotype, non-enhanceable by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has genitalia phenotype, non-enhanceable by CycA[+]/CycA^unspecified

(Nakato et al., 2002)

Suppressed by

Statement

Reference

dally⁸⁰/dally⁰⁶⁴⁶⁴ has ovary | larval stage phenotype, suppressible by Scer\GAL4^C587/dpp^UAS.cUa.GFP

(Liu et al., 2024)

dally⁸⁰/dally⁰⁶⁴⁶⁴ has ovary | larval stage phenotype, suppressible by Scer\GAL4^nanos.PG/Kr^UASz.Tag:HA

(Liu et al., 2024)

dally⁰⁶⁴⁶⁴ has antenna phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has antenna phenotype, suppressible by CycA[+]/CycA⁵

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has lamina anlage & mitotic cell cycle phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has ommatidium phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has ommatidium phenotype, suppressible by CycA[+]/CycA⁵

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has wing vein L5 phenotype, suppressible by CycA³/CycA[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has wing vein L5 phenotype, suppressible by CycA[+]/CycA⁵

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has wing phenotype, suppressible by arm^act.UAS/Scer\GAL4^bbg-C96

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ has wing margin bristle phenotype, suppressible by arm^act.UAS/Scer\GAL4^bbg-C96

(Lin and Perrimon, 1999)

dally^gem/dally⁰⁶⁴⁶⁴ has genitalia phenotype, suppressible by wg[+]/wg^l-17

(Tsuda et al., 1999)

dally⁰⁶⁴⁶⁴ has wing phenotype, suppressible by dpp^d14/dpp[+]

(Jackson et al., 1997)

NOT suppressed by

Statement

Reference

dally⁰⁶⁴⁶⁴ has antenna phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has genitalia phenotype, non-suppressible by CycA[+]/CycA^unspecified

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has genitalia phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has lamina anlage & mitotic cell cycle phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has lamina anlage & mitotic cell cycle phenotype, non-suppressible by stg²/stg[+]

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has ommatidium phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

dally⁰⁶⁴⁶⁴ has wing vein L5 phenotype, non-suppressible by Df(2R)59AB/+

(Nakato et al., 2002)

Enhancer of

Statement

Reference

dally⁰⁶⁴⁶⁴ is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, fz2^UAS.N

(Lin and Perrimon, 1999)

dally⁰⁶⁴⁶⁴ is an enhancer of wing margin bristle phenotype of Scer\GAL4^bbg-C96, fz2^UAS.N

(Lin and Perrimon, 1999)

NOT Enhancer of

Statement

Reference

dally⁰⁶⁴⁶⁴ is a non-enhancer of anterior fascicle & axon | ectopic phenotype of Lar^bypass

(Fox and Zinn, 2005)

dally[+]/dally⁰⁶⁴⁶⁴ is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

dally[+]/dally⁰⁶⁴⁶⁴ is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Suppressor of

Statement

Reference

dally⁰⁶⁴⁶⁴ is a suppressor of phenotype of wg^PE2

(Moline et al., 2000)

dally⁰⁶⁴⁶⁴ is a suppressor of wing phenotype of Scer\GAL4^69B, fz2^UAS.cCa

(Lin and Perrimon, 1999)

NOT Suppressor of

Statement

Reference

dally[+]/dally⁰⁶⁴⁶⁴ is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

dally[+]/dally⁰⁶⁴⁶⁴ is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Other

Statement

Reference

Scer\GAL4^nanos.PG, dally⁸⁰/dally⁰⁶⁴⁶⁴, tll^{UAS.ORF.GW.Tag:HA} has ovary | larval stage phenotype

(Liu et al., 2024)

Kr^KK105429, Scer\GAL4^nanos.PG, dally⁸⁰/dally⁰⁶⁴⁶⁴ has ovary | larval stage phenotype

(Liu et al., 2024)

Scer\GAL4^tj.PU, dally⁸⁰/dally⁰⁶⁴⁶⁴, tsl^UAS.cSa has ovary | larval stage phenotype

(Liu et al., 2024)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d-blk has eye phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has eye phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has antenna phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has eye phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d5 has antenna phenotype

(Jackson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The dally⁰⁶⁴⁶⁴ mutation does not increase the frequency of the Lar^bypass ISNb bypass phenotype.

(Fox and Zinn, 2005)

The lethality seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵. The penetrance of the eye, antenna and wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA⁵. The lethality seen in dally⁰⁶⁴⁶⁴ homozygotes is completely suppressed if they are also heterozygous for CycA³. The penetrance of the eye, antenna and wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes is reduced if they are also heterozygous for CycA³. The severity of the dally⁰⁶⁴⁶⁴ eye defects are also reduced in the double mutants. The ability of dally⁰⁶⁴⁶⁴ lamina precursor neurons to enter a second division cycle is largely restored if they are also carrying CycA³. Df(2R)59AB has no effect on the divisions of dally⁰⁶⁴⁶⁴ lamina precursor neurons. One copy of stg² does not rescue the second division in dally⁰⁶⁴⁶⁴ lamina precursor neurons and appears to expand the first G2/M domain of lamina precursor neuron division.

(Nakato et al., 2002)

The addition of wg^l-17 to dally^gem/dally⁰⁶⁴⁶⁴ flies, leads to enhancement of the posterior supraalar bristle phenotype seen in dally^gem/dally⁰⁶⁴⁶⁴ flies alone: 30% of flies have the phenotype, rather than 1%. The addition of put¹⁰⁴⁶⁰ to dally^gem/dally⁰⁶⁴⁶⁴ flies, leads to enhancement of the anterior dorsocentral bristle phenotype seen in dally^gem/dally⁰⁶⁴⁶⁴ flies alone: 90% of flies have the phenotype, rather than 24%. The posterior supraalar bristle phenotype is also enhanced by the addition of put¹⁰⁴⁶⁰. All flies have the phenotype, rather than 86%.

(Fujise et al., 2001)

Homozygous embryos derived from dally⁰⁶⁴⁶⁴ germline clones show weak segment polarity defects (8% penetrance). More severe defects are detected in embryos where the maternal sfl message is also eliminated (14% penetrance). The segment polarity phenotype seen in embryos derived from dally⁰⁶⁴⁶⁴ germline clones is enhanced if zygotic wg is reduced by half. Penetrance is increased from 8% to 16%. Wings on wg^l-8/+; dally⁰⁶⁴⁶⁴/dally⁰⁶⁴⁶⁴ animals show a stronger wing notch phenotype than dally⁰⁶⁴⁶⁴/dally⁰⁶⁴⁶⁴ alone at a higher penetrance (3% to 8%). dally⁰⁶⁴⁶⁴/dally⁰⁶⁴⁶⁴ strongly enhances the fully penetrant mild wing margin defect see when ectopic expression of fz2^Scer\UAS.N at the presumptive wing margin is driven by Scer\GAL4^C96. The wing margin phenotype seen in dally⁰⁶⁴⁶⁴/dally⁰⁶⁴⁶⁴, is fully suppressed by ectopic expression of arm^act.Scer\UAS driven by Scer\GAL4^C96. The ectopic bristle phenotype seen when fz2^Scer\UAS.cCa is driven uniformly in the wing pouch by Scer\GAL4^69B is strikingly reduced in fz2^Scer\UAS.cCa, dally⁰⁶⁴⁶⁴/Scer\GAL4^69B, dally⁰⁶⁴⁶⁴ flies.

(Lin and Perrimon, 1999)

The abnormal genitalia phenotype of dally⁰⁶⁴⁶⁴/dally^gem flies is dominantly suppressed (down to less than 10% penetrance) by wg^l-17.

(Tsuda et al., 1999)

Flies heterozygous for both dally⁰⁶⁴⁶⁴ and dpp^d-blk show eye abnormalities never observed in flies heterozygous for dally⁰⁶⁴⁶⁴ or dpp^d-blk alone. dally⁰⁶⁴⁶⁴ homozygotes show a slight reduction in the eye which is more severe when they are also heterozygous for dpp^d-blk. The penetrance and expressivity of eye, antenna and genitalia defects seen in dally⁰⁶⁴⁶⁴ homozygotes is increased if they are also heterozygous for dpp^d14. The wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes are suppressed if they are also heterozygous for dpp^d14. The penetrance of eye, antenna and genitalia defects seen in dally⁰⁶⁴⁶⁴ homozygotes is decreased if they are carrying three copies of dpp⁺. The wing defects seen in dally⁰⁶⁴⁶⁴ homozygotes are enhanced if they are carrying three copies of dpp⁺.

(Jackson et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dally⁸⁰/dally⁰⁶⁴⁶⁴ is rescued by Scer\GAL4^C587/dally^UAS.cUa

(Liu et al., 2024)

dally⁸⁰/dally⁰⁶⁴⁶⁴ is rescued by dally^UAS.cUa/Scer\GAL4^tj.PU

(Liu et al., 2024)

Not rescued by

dally⁸⁰/dally⁰⁶⁴⁶⁴ is not rescued by Scer\GAL4^nanos.PG/dally^UAS.cUa

(Liu et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11685

P{PZ}dally⁰⁶⁴⁶⁴ P{PZ}l(3)87Df⁰⁶⁴⁶⁴ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Kyoto

109041

w^*; P{PZ}ken⁰⁰⁶²⁸ / CyO; P{PZ}dally⁰⁶⁴⁶⁴ / TM3, Ser¹

Notes on Origin

Discoverer

A. Spradling.

Separable from: l(3)87Df⁰⁶⁴⁶⁴. Evidence suggests that the "l(3)06464" line contains 2 P{PZ} insertions; one at 87D in l(3)87Df (P{PZ}l(3)87Df⁰⁶⁴⁶⁴) corresponding to the site of the flanking sequence AQ073333, and one at 66E (P{PZ}dally⁰⁶⁴⁶⁴) which causes a mutation in dally.

(FlyBase, 1996-)

Comments

Complements: l(3)01629⁰¹⁶²⁹. Complements: l(3)06264⁰⁶²⁶⁴. Complements: mRpL12¹⁰⁵³⁴. Complements: mRpL12^j4B2. Complements: l(3)neo14¹. Complements: mRpL12^rL424. Complements: l(3)s2383^s2383.

(BDGP Project Members, 1994-1999)

Reversion of the P-element insertion provides evidence that the insertion is responsible for the mutant phenotype.

(Nakato et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

dally⁰⁶⁴⁶⁴

(Ma et al., 2019, Curtis et al., 2013)

dally⁰⁶⁴⁸⁴

(Aw et al., 2017)

dally^P2

(Ma et al., 2019, Eugster et al., 2007, Yan and Lin, 2007, Desbordes et al., 2005, Franch-Marro et al., 2005, Han et al., 2005, Araujo et al., 2003, Nakato et al., 2002, Fujise et al., 2001, Strigini and Cohen, 2000, Lin and Perrimon, 1999, Tsuda et al., 1999, Jackson et al., 1997, Nakato et al., 1995)

dally^PZ

(Guo and Wang, 2009)

dally^pz

(Liu et al., 2024)

l(3)06464

(Desbordes et al., 2005, Spradling et al., 1999)

l(3)06464⁰⁶⁴⁶⁴

sl(3)06464

(Nakato et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (26)

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