FlyBase Allele Report: Dmel\RpS3[1]

General Information

Symbol

Dmel\RpS3¹

Species

D. melanogaster

Name

FlyBase ID

FBal0011950

Feature type

allele

Associated gene

Dmel\RpS3

Associated Insertion(s)

Carried in Construct

Also Known As

M(3)w, M(3R)w

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult midgut

(Okumura et al., 2019)

eye

(Dunn and Mossige, 1937)

macrochaeta

(Okumura et al., 2019, Ferrus, 1975, Dunn and Mossige, 1937)

Detailed Description

Statement

Reference

RpS3¹ heterozygous adults exhibit a Minute phenotype (shorter and thinner bristles than wild-type flies), as well as a progressive decrease in climbing ability. Their midguts exhibit increased DNA damage (accumulation of 8-oxoG and γH2AvD).

(Okumura et al., 2019)

There is an increase in the level of apoptosis in the wing discs of RpS3¹/+ larvae.

(Coelho et al., 2005)

Mutant cells do not exhibit any mitotic defects.

(Fung et al., 2002)

Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 36 hours.

(Ferrus, 1975)

Heterozygotes have a Minute bristle phenotype and the eyes occasionally show a slight roughness. Larval development of heterozygotes is delayed by about 3.3 days at 25^oC compared to control siblings. Larval development of heterozygotes is delayed by about 2.8 days at 21 +/- 2^oC compared to control siblings.

(Dunn and Mossige, 1937)

strong Minute Strongly reduced bristles. Good viability and fertility. Delays puparium formation about 42 hr at 25^oC; first and second instars also delayed (Brehme, 1941). Homozygote dies in first instar. RpS3¹ enhances L, B (Dunn and Coyne, 1935), Bx³, N^Co, N^fa-1, ap⁴, Jag, Ser, sens, and ap^Xa (Bryson, 1940). Treanor (1962) suggests that the mitochondrial membrane is defective and labile phosphate formation is disturbed. Recovery of RpS3¹ from RpS3¹/In(3R)C, l(3)a mothers is reduced (Schultz). RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

RpS3¹ has abnormal DNA repair | adult stage | dominant phenotype, enhanceable by Ogg1^f08013

(Okumura et al., 2019)

Suppressed by

Statement

Reference

Delta¹, RpS3[+]/RpS3¹ has lethal phenotype, suppressible | partially by H¹

(Schultz, 1929)

Dl[+]/Delta¹, RpS3¹ has lethal phenotype, suppressible | partially by H¹

(Schultz, 1929)

Enhancer of

Statement

Reference

RpS3[+]/RpS3¹ is an enhancer of abnormal DNA repair phenotype of Ogg1^f08013

(Okumura et al., 2019)

RpS3[+]/RpS3¹ is an enhancer of increased cell death phenotype of pix^L17

(Coelho et al., 2005)

RpS3[+]/RpS3¹ is an enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

Other

Statement

Reference

Delta¹, RpS3¹ has lethal | dominant phenotype

(Schultz, 1929)

Delta³, RpS3[+]/RpS3¹ has viable phenotype

(Schultz, 1929)

Delta³/Dl[+], RpS3¹ has viable phenotype

(Schultz, 1929)

Dl[+]/Delta¹, RpS3¹ has lethal phenotype

(Schultz, 1929)

Phenotype Manifest In

Enhanced by

Statement

Reference

RpS3¹ has adult midgut phenotype, enhanceable by Ogg1^f08013

(Okumura et al., 2019)

NOT Enhanced by

Statement

Reference

RpS3¹ has phenotype, non-enhanceable by M(3)69E¹

(Schultz, 1929)

RpS3¹ has phenotype, non-enhanceable by M(3)96CF¹

(Schultz, 1929)

RpS3¹ has phenotype, non-enhanceable by M(3)99E¹

(Schultz, 1929)

RpS3¹ has phenotype, non-enhanceable by M(2)31A¹

(Schultz, 1929)

RpS3¹ has phenotype, non-enhanceable by M(2)58F¹

(Schultz, 1929)

RpS3¹ has phenotype, non-enhanceable by M(2)p¹

(Schultz, 1929)

NOT suppressed by

Statement

Reference

RpS3¹ has phenotype, non-suppressible by M(3)69E¹

(Schultz, 1929)

RpS3¹ has phenotype, non-suppressible by M(3)96CF¹

(Schultz, 1929)

RpS3¹ has phenotype, non-suppressible by M(3)99E¹

(Schultz, 1929)

RpS3¹ has phenotype, non-suppressible by M(2)31A¹

(Schultz, 1929)

RpS3¹ has phenotype, non-suppressible by M(2)58F¹

(Schultz, 1929)

RpS3¹ has phenotype, non-suppressible by M(2)p¹

(Schultz, 1929)

Enhancer of

Statement

Reference

RpS3[+]/RpS3¹ is an enhancer of adult midgut phenotype of Ogg1^f08013

(Okumura et al., 2019)

RpS3[+]/RpS3¹ is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

RpS3[+]/RpS3¹ is an enhancer of phenotype of J¹

(Schultz, 1929)

NOT Enhancer of

Statement

Reference

RpS3¹ is a non-enhancer of phenotype of M(3)69E⁵

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(3)96CF¹

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(3)99E¹

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(2)31A¹

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(2)58F¹

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(2)p¹

(Schultz, 1929)

RpS3¹ is a non-enhancer of phenotype of M(3)69E¹

(Schultz, 1929)

Suppressor of

Statement

Reference

RpS3[+]/RpS3¹ is a suppressor of female germline stem cell phenotype of piwi²

(Smulders-Srinivasan and Lin, 2003)

NOT Suppressor of

Statement

Reference

RpS3¹ is a non-suppressor of phenotype of M(2)58F¹

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(3)69E⁵

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(2)31A¹

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(2)p¹

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(3)69E¹

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(3)96CF¹

(Schultz, 1929)

RpS3¹ is a non-suppressor of phenotype of M(3)99E¹

(Schultz, 1929)

Additional Comments

Genetic Interactions

Statement

Reference

Although apoptosis is similar to wild-type controls in pix^L17/+ wing discs, levels are enhanced in pix^L17/+, RpS3¹/+ double mutants.

(Coelho et al., 2005)

Dl³ is viable in double heterozygous combination with RpS3¹. The lethality of Dl¹ RpS3¹ heterozygotes is partially suppressed by H¹.

(Schultz, 1929)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (2)

Bloomington

527

l(3)ac¹ e^s RpS3¹/LVM

Kyoto

101691

l(3)ac¹ e^s RpS3¹ / LVM, pe¹ l(3)LVML¹ l(3)LVMR¹

Notes on Origin

Discoverer

Schultz, 1925.

Comments

Not suppressed by RpL32^+t3.3.

(Kongsuwan et al., 1985)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

M(3)95A1

(Andersson et al., 1994)

M(3)95A¹

(Coelho et al., 2005)

M(3)w

(Molnar et al., 2011, Rasmuson-Lestander et al., 1993, Kongsuwan et al., 1985)

M(3R)w

(Hasegawa et al., 2011, Ferrus, 1975)

M_w

(Schultz, 1929)

(Dunn and Mossige, 1937)

RpS3¹

(Okumura et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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