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General Information
Symbol
Dmel\snw
Species
D. melanogaster
Name
weak
FlyBase ID
FBal0015885
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Contains a pair of adjacent defective P elements of 0.95 kb and 1.15 kb inserted in head-to-head orientation between -0.589 and -0.582 kb. All sne derivatives tested retain only the 1.15 kb element and all normal-appearing derivatives retain only the 0.95 kb element, thus the symbol sn(+).

Contains two defective P-elements in tandem.

Tandem insertion of two small P-elements.

Insertion of two inverted P-elements.

snw contains two P-element insertions, of 1.15kb and 0.95kb, inserted at the same site in inverted orientation, with only the 8bp duplication (in this case of sn sequence) usually found bounding an inserted P-element between them. The insertion is in the region -2.0 to 0.0.

Insertion of a 2 kb P element.

Insertion components
P{}sn-w-a
P{}sn-w-b
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Bristle phenotype is suppressed by su(s)71, and partly suppressed by su(s)sn-w:R.

Repression potential of a P-element repressor protein in a singed sterility assay of snw/snX2 heterozygotes shows partial correspondence with gonadal dysgenic sterility in that strong repression of gonadal dysgenic sterility shows some effect in the singed sterility assay.

Weak singed phenotype, probably class 2. Highly mutable in dysgenic genotypes; 40% to 60% of offspring are either normal (sn(+)) or extreme singed (sne) in phenotype. These derivatives are in turn mutable, but at much lower levels. Completely stable in non-dysgenic genotypes. Gnarled macrochaetae and kinky microchaetae.

The presence of P\T66 causes a drastic reduction in destabilisation of snw to sne or sn(+). This repression is not increased by P\T66D1.hs, but it is increased by P\T66C2.hs.

Can mutate during a dysgenic cross to either wild type phenotype or a more extreme (sne) bristle phenotype depending on which one of the P-elements excises.

Phenotype is unaffected by mod(mdg4)ul.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

snw has phenotype, non-enhanceable by ph-pP1

Additional Comments
Genetic Interactions
Statement
Reference

The viability of Mnn1e200 mutants (Df(2L)Mnn1e200 mutants in which milt function is rescued by expression of the milt+22 transgene) is not affected by a snw background.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (8)
Notes on Origin
Discoverer
Comments
Comments

P{Icarus} destabilises the mutation snw in germ line cells at a maximal rate even without heat shock. P{Icarus} does not destabilise snw in somatic cells.

snw is hypermutable in the M cytotype, mutating either to a more extreme allele (sne), or reverting to wild type. This mutation rate can exceed 50%, with the two derivatives being generated at approximately equal rates. This hypermutability is probably due to the presence of two P-element insertions in snw.

Some somatic reversion of this allele is seen. The rate of somatic reversion is 0.06%. The movements of the P-elements in these somatic reversions occur early in development, and require a trans-acting maternal effect component (P\TMo). Somatic reversion occurs preferentially in attached-X stocks.

Unstable in the M cytotype in the presence of a transposase, mutating either to sne (a more extreme allele) or to sn+ (apparent wild-type).

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
weak
Secondary FlyBase IDs
    References (51)