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General Information
Symbol
Dmel\Su(var)3-96
Species
D. melanogaster
Name
FlyBase ID
FBal0016562
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)3-906
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of an approximately 6kb DNA fragment.

Insertion of unknown DNA.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mislocalization of Su(var)3-96 during oogenesis by expressing the JabbaUASp.vhhGFP4 nanobody under the control of Scer\GAL4VP16.mat.αTub67C leads to almost complete embryonic lethality of the progeny.

Su(var)3-96 does not suppress the position effect variegation of the w gene that is seen in the P{hsp26-pt-T}Dyrk3118E-15 insertion.

Su(var)3-96 can be maintained as a homozygous stock, although homozygotes are less healthy and fecund than wild type.

The fourth chromosome appears hypercondensed in polytene chromosomes of mutant salivary glands.

Su(var)3-96/+ completely suppresses the position effect variegation of the Sb1 allele that is seen in the T(2;3)SbV chromosome.

Su(var)3-96/Su(var)3-96 suppresses the position effect variegation of the w gene that is seen in the In(1)wm4 chromosome.

Su(var)3-96 dominantly suppresses variegation of the w gene caused by In(1)wm4.

Su(var)3-96 does not dominantly suppress variegation of the w gene caused by P{RS5}5-HA-1902, P{RS5}5-HA-1992 or P{RS3}panCB-5204-3.

One copy of Su(var)3-96 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(var)3-96 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

The chromocenter is unusually large and appears more decondensed than normal in the salivary gland polytene chromosomes of homozygous mutants.

Region 20A-F of the In(1)wm4h salivary gland polytene chromosome acquires a distinct banding pattern in the Su(var)3-96 mutant background; in contrast to the one or two bands usually seen a Su(var)3-9+ background, up to 14-18 bands are seen. In addition, a large pseudopuff is seen in the area of the 20F-3C eu-heterochromatin junction.

Su(var)3-96 flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

Heterozygotes show a suppression of the position effect variegation seen in In(1)wm4. This phenotype dominates the enhancement of PEV caused by the loss of a Y chromosome.

Heterozygotes show no effect on crossing over between kni and pp.

Strong suppressors of bw and w position effect variegation (PEV).

mod(mdg4)neo129 suppresses the strong dominant suppressor effect.

Dominant suppressor of position effect variegation at the w locus caused by In(1)wm4h.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
Suppressor of
Statement
Reference

Su(var)3-9[+]/Su(var)3-96 is a suppressor | partially of lethal | recessive phenotype of JIL-1z2

Other
Phenotype Manifest In
Suppressor of
Statement
Reference

Su(var)3-9[+]/Su(var)3-96 is a suppressor | partially of polytene chromosome phenotype of JIL-1z2

Other
Additional Comments
Genetic Interactions
Statement
Reference

Flies carrying one copy of T(2;3)SbV frequently display a mosaic thoracic bristle phenotype, wherein bristles are both short and long, a phenotype that is enhanced by one copy of Su(var)3-96.

Polytene chromosomes in egg1473 ; Su(var)3-96 double mutant larval salivary glands are less condensed than normal and the chromocenter is ill defined.

egg235/+ reduces condensation of polytene chromosome 4 in Su(var)3-96 mutants. The chromosome is often broader and shorter than in wild type.

The most proximal part of region 20 of the salivary gland polytene X chromosomes appears decompacted in SuURES Su(var)3-96 double mutants.

The lethality of JIL-1z2 homozygotes is significantly suppressed by one copy of Su(var)3-96 (60.7% viability).

The abnormal polytene chromosome morphology seen in JIL-1z2 homozygous third instar larvae is partially suppressed by Su(var)3-96/+ or Su(var)3-96/Su(var)3-96; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

The combination of Su(var)3-96 and either Su(var)3-7+t10.4 or Su(var)205+tSa leads to a Su(var)3-96 like position effect variegation (PEV) phenotype - i.e. suppression of PEV in In(1)wm4.

Su(var)3-96 Df(3R)Ace-HD1 double mutants show an increase in crossing over between kni and pp. Su(var)2055 Su(var)3-96 double heterozygotes show an increase in crossing over between kni and pp.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)wm4h, and a dominant enhancer of position effect variegation, E(var)c1011.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (5)
References (34)