FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Su(var)3-96
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General Information
Symbol
Dmel\Su(var)3-96
Species
D. melanogaster
Name
FlyBase ID
FBal0016562
Feature type
allele
Associated gene
Dmel\Su(var)3-9
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)3-906
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Reuter et al., 1986)
X ray
(Westphal and Reuter, 2002, Tschiersch et al., 1994)
Progenitor genotype
Cytology
Description

Insertion of an approximately 6kb DNA fragment.

(Westphal and Reuter, 2002)

Insertion of unknown DNA.

(Tschiersch et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      decreased fecundity | recessive

      (Brower-Toland et al., 2009)

      enhancer of variegation, with P{hsp26-pt-T}39C-12

      (Haynes et al., 2007)

      enhancer of variegation, with P{hsp26-pt-T}gw39C-33

      (Haynes et al., 2007)

      enhancer of variegation | dominant, with P{hsp26-pt-T}39C-12

      (Brower-Toland et al., 2009)

      enhancer of variegation | dominant, with P{hsp26-pt-T}118E-25-5

      (Brower-Toland et al., 2009)

      non-suppressor of variegation

      (Cryderman et al., 2011)

      non-suppressor of variegation | dominant, with P{RS3}panCB-5204-3

      (Phalke et al., 2009)

      non-suppressor of variegation | dominant, with P{RS5}5-HA-1902

      (Phalke et al., 2009)

      non-suppressor of variegation | dominant, with P{RS5}5-HA-1992

      (Phalke et al., 2009)

      non-suppressor of variegation | dominant, with T(2;3)V21-P{lacW}92E.x3

      (Phalke et al., 2009)

      partially lethal - majority live

      (Romanov et al., 2023)

      partially lethal - majority live (with Su(var)3-91)

      (Romanov et al., 2023)

      partially lethal - majority live (with Su(var)3-913)

      (Romanov et al., 2023)

      partially lethal - majority live (with Su(var)3-922)

      (Romanov et al., 2023)

      some die during embryonic stage

      (Romanov et al., 2023)

      some die during P-stage

      (Romanov et al., 2023)

      some die during P-stage (with Su(var)3-913)

      (Romanov et al., 2023)

      some die during P-stage (with Su(var)3-922)

      (Romanov et al., 2023)

      suppressor of variegation

      (Schotta et al., 2002)

      suppressor of variegation, with P{hsp26-pt-T}39C-3

      (Haynes et al., 2007)

      suppressor of variegation, with P{hsp26-pt-T}39C-27

      (Haynes et al., 2007)

      suppressor of variegation, with P{hsp26-pt-T}118E-10

      (Haynes et al., 2007)

      suppressor of variegation, with P{T1(-FRT)}T190-177

      (Haynes et al., 2006)

      suppressor of variegation, with P{T1}T190-177

      (Haynes et al., 2006)

      suppressor of variegation, with P{w+(FRT.attP.1360)}1198

      (Sentmanat and Elgin, 2012)

      suppressor of variegation | adult stage, with In(1)wm4h

      (Yushkova et al., 2025)

      suppressor of variegation | dominant

      (Fagegaltier et al., 2009)

      suppressor of variegation | dominant, with In(1)wm4

      (Phalke et al., 2009, Doheny et al., 2008)

      suppressor of variegation | dominant, with In(1)wm4h

      (Tschiersch et al., 1994, Dorn et al., 1993, Reuter et al., 1986)

      suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76

      (Wang et al., 2014)

      suppressor of variegation | dominant, with P{hsp26-pt-T}39C-2

      (Brower-Toland et al., 2009)

      suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

      (Doheny et al., 2008)

      suppressor of variegation | dominant, with P{hsp26-pt-T}39C-66

      (Wang et al., 2014)

      suppressor of variegation | dominant, with P{hsp26-pt-T}118E-10

      (Brower-Toland et al., 2009)

      suppressor of variegation | dominant, with P{hsp26-pt-T}118E-28a, P{hsp26-pt-T}118E-28b

      (Brower-Toland et al., 2009)

      viable

      (Brower-Toland et al., 2009, Reuter et al., 1986)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mislocalization of Su(var)3-96 during oogenesis by expressing the JabbaUASp.vhhGFP4 nanobody under the control of Scer\GAL4VP16.mat.αTub67C leads to almost complete embryonic lethality of the progeny.

      (Seller et al., 2019)

      Su(var)3-96 does not suppress the position effect variegation of the w gene that is seen in the P{hsp26-pt-T}Dyrk3118E-15 insertion.

      (Cryderman et al., 2011)

      Su(var)3-96 can be maintained as a homozygous stock, although homozygotes are less healthy and fecund than wild type.

      The fourth chromosome appears hypercondensed in polytene chromosomes of mutant salivary glands.

      (Brower-Toland et al., 2009)

      Su(var)3-96/+ completely suppresses the position effect variegation of the Sb1 allele that is seen in the T(2;3)SbV chromosome.

      Su(var)3-96/Su(var)3-96 suppresses the position effect variegation of the w gene that is seen in the In(1)wm4 chromosome.

      (Fagegaltier et al., 2009)

      Su(var)3-96 dominantly suppresses variegation of the w gene caused by In(1)wm4.

      Su(var)3-96 does not dominantly suppress variegation of the w gene caused by P{RS5}5-HA-1902, P{RS5}5-HA-1992 or P{RS3}panCB-5204-3.

      (Phalke et al., 2009)

      One copy of Su(var)3-96 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Su(var)3-96 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      The chromocenter is unusually large and appears more decondensed than normal in the salivary gland polytene chromosomes of homozygous mutants.

      Region 20A-F of the In(1)wm4h salivary gland polytene chromosome acquires a distinct banding pattern in the Su(var)3-96 mutant background; in contrast to the one or two bands usually seen a Su(var)3-9+ background, up to 14-18 bands are seen. In addition, a large pseudopuff is seen in the area of the 20F-3C eu-heterochromatin junction.

      (Demakova et al., 2007)

      Su(var)3-96 flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

      (Haynes et al., 2006)

      Heterozygotes show a suppression of the position effect variegation seen in In(1)wm4. This phenotype dominates the enhancement of PEV caused by the loss of a Y chromosome.

      (Schotta et al., 2002)

      Heterozygotes show no effect on crossing over between kni and pp.

      (Westphal and Reuter, 2002)

      Strong suppressors of bw and w position effect variegation (PEV).

      (Tschiersch et al., 1994)

      mod(mdg4)neo129 suppresses the strong dominant suppressor effect.

      (Dorn et al., 1993)

      Dominant suppressor of position effect variegation at the w locus caused by In(1)wm4h.

      (Reuter et al., 1986)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Su(var)3-96 has suppressor of variegation phenotype, non-enhanceable by Su(var)205+tSa

      (Schotta et al., 2002)

      Su(var)3-96 has suppressor of variegation phenotype, non-enhanceable by Su(var)3-7+t10.4

      (Schotta et al., 2002)
      Suppressor of
      Statement
      Reference

      Su(var)3-96/Su(var)3-96 is a suppressor of lethal | recessive phenotype of egg1473

      (Brower-Toland et al., 2009)

      Su(var)3-9[+]/Su(var)3-96 is a suppressor of lethal | recessive phenotype of JIL-1z2

      (Deng et al., 2007)
      Other
      Statement
      Reference

      Df(2R)Dll-MP/egg1473, Su(var)3-91/Su(var)3-96 has some die during P-stage phenotype

      (Romanov et al., 2023)

      Df(2R)Dll-MP/egg1473, Su(var)3-91/Su(var)3-96 has some die during larval stage phenotype

      (Romanov et al., 2023)

      Df(2R)Dll-MP/egg1473, Su(var)3-91/Su(var)3-96 has visible | P-stage phenotype

      (Romanov et al., 2023)

      Df(2R)Dll-MP/egg1473, Su(var)3-96 has lethal phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has abnormal developmental rate phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has melanotic necrosis | third instar larval stage phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has lethal phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has majority die during embryonic stage phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has visible | P-stage phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has visible | third instar larval stage phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has some die during P-stage phenotype

      (Romanov et al., 2023)

      Su(var)3-96, egg1473 has some die during larval stage phenotype

      (Romanov et al., 2023)

      G9a32.13, Su(var)3-96, egg1473 has lethal phenotype

      (Romanov et al., 2023)

      G9a32.13, Su(var)3-96, egg1473 has some die during P-stage phenotype

      (Romanov et al., 2023)

      G9a32.13, Su(var)3-96, egg1473 has some die during larval stage phenotype

      (Romanov et al., 2023)

      Df(2R)Dll-MP/egg1473, Su(var)3-91/Su(var)3-96 has lethal phenotype

      (Romanov et al., 2023)

      G9aRNAi.UAS.cBa, Scer\GAL4Act5C.PU, Su(var)3-96 has viable phenotype

      (Brower-Toland et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(var)3-9[+]/Su(var)3-96 is a suppressor of polytene chromosome phenotype of JIL-1z2

      (Deng et al., 2007)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying one copy of T(2;3)SbV frequently display a mosaic thoracic bristle phenotype, wherein bristles are both short and long, a phenotype that is enhanced by one copy of Su(var)3-96.

      (Glenn and Geyer, 2019)

      Polytene chromosomes in egg1473 ; Su(var)3-96 double mutant larval salivary glands are less condensed than normal and the chromocenter is ill defined.

      egg235/+ reduces condensation of polytene chromosome 4 in Su(var)3-96 mutants. The chromosome is often broader and shorter than in wild type.

      (Brower-Toland et al., 2009)

      The most proximal part of region 20 of the salivary gland polytene X chromosomes appears decompacted in SuURES Su(var)3-96 double mutants.

      (Demakova et al., 2007)

      The lethality of JIL-1z2 homozygotes is significantly suppressed by one copy of Su(var)3-96 (60.7% viability).

      The abnormal polytene chromosome morphology seen in JIL-1z2 homozygous third instar larvae is partially suppressed by Su(var)3-96/+ or Su(var)3-96/Su(var)3-96; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

      (Deng et al., 2007)

      The combination of Su(var)3-96 and either Su(var)3-7+t10.4 or Su(var)205+tSa leads to a Su(var)3-96 like position effect variegation (PEV) phenotype - i.e. suppression of PEV in In(1)wm4.

      (Schotta et al., 2002)

      Su(var)3-96 Df(3R)Ace-HD1 double mutants show an increase in crossing over between kni and pp. Su(var)2055 Su(var)3-96 double heterozygotes show an increase in crossing over between kni and pp.

      (Westphal and Reuter, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Su(var)3-96 is rescued by Su(var)3-9+t11.5

      (Schotta et al., 2002)
      Partially rescued by

      Su(var)3-96 is partially rescued by Su(var)3-9UAS.EGFP/Scer\GAL4Sgs3.PD

      (Demakova et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)wm4h, and a dominant enhancer of position effect variegation, E(var)c1011.

      (Reuter et al., 1986)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (5)
      References (44)