FlyBase Allele Report: Dmel\sxc[1]

General Information

Symbol

Dmel\sxc¹

Species

D. melanogaster

Name

FlyBase ID

FBal0016675

Feature type

allele

Associated gene

Dmel\sxc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

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Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2R:5,327,732..5,327,732 [+]

Nucleotide change:

G5327732A

Reported nucleotide change:

G?A

Amino acid change:

W894term | sxc-PA; W894term | sxc-PB; W894term | sxc-PC

Reported amino acid change:

W894term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

(Gambetta et al., 2009, Sinclair et al., 2009)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: W894term.

(Gambetta et al., 2009, Sinclair et al., 2009)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile (with sxc²)

(Gambetta et al., 2009)

lethal (with sxc^K872M)

(Mariappa et al., 2018)

lethal - all die before end of larval stage | maternal effect (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^D955A.UAS

(Mariappa et al., 2015)

lethal - all die before end of P-stage (with sxc⁶)

(Mariappa et al., 2015, Gambetta et al., 2009)

lethal - all die before end of P-stage (with sxc⁷)

(Gambetta et al., 2009)

majority die during embryonic stage | maternal effect | heat sensitive (with sxc⁰²⁶³⁷), with Scer\GAL4^da.G32, sxc^UAS.cSa

(Radermacher et al., 2014)

some die during pharate adult stage (with sxc⁶)

(Gambetta et al., 2009)

some die during pharate adult stage (with sxc⁷)

(Gambetta et al., 2009)

viable (with sxc²)

(Gambetta et al., 2009)

viable (with sxc^H537A)

(Pravata et al., 2019)

viable (with sxc^N595K-10.3)

(Pravata et al., 2019)

viable (with sxc^N595K-19.1)

(Pravata et al., 2019)

visible (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^D955A.UAS

(Mariappa et al., 2015)

visible (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H537A.UAS

(Mariappa et al., 2015)

visible (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H596F.UAS

(Mariappa et al., 2015)

visible (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^UAS.cMa

(Mariappa et al., 2015)

Phenotype Manifest In

abdominal segment 1

(Lindsley and Zimm, 1992)

abdominal segment 4

(Lindsley and Zimm, 1992)

abdominal segment 5

(Lindsley and Zimm, 1992)

antenna

(Lindsley and Zimm, 1992)

larval abdominal segment 1

(Lindsley and Zimm, 1992)

larval abdominal segment 2

(Lindsley and Zimm, 1992)

larval abdominal segment 3

(Lindsley and Zimm, 1992)

larval abdominal segment 4

(Lindsley and Zimm, 1992)

larval abdominal segment 5

(Lindsley and Zimm, 1992)

larval abdominal segment 6

(Lindsley and Zimm, 1992)

larval abdominal segment 7

(Lindsley and Zimm, 1992)

larval mesothoracic segment

(Lindsley and Zimm, 1992)

larval metathoracic segment

(Lindsley and Zimm, 1992)

larval prothoracic segment

(Lindsley and Zimm, 1992)

mesothoracic leg

(Lindsley and Zimm, 1992)

metathoracic leg

(Lindsley and Zimm, 1992)

wing

(Lindsley and Zimm, 1992)

wing (with sxc²)

(Gambetta et al., 2009)

wing (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^D955A.UAS

(Mariappa et al., 2015)

wing (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H537A.UAS

(Mariappa et al., 2015)

wing (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H596F.UAS

(Mariappa et al., 2015)

wing (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^UAS.cMa

(Mariappa et al., 2015)

wing vein | ectopic (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^D955A.UAS

(Mariappa et al., 2015)

wing vein | ectopic (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H537A.UAS

(Mariappa et al., 2015)

wing vein | ectopic (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^H596F.UAS

(Mariappa et al., 2015)

wing vein | ectopic (with sxc⁶), with Scer\GAL4^Tub.PU, sxc^UAS.cMa

(Mariappa et al., 2015)

Detailed Description

Statement

Reference

sxc¹ is lethal in combination with sxc^K872M.

(Mariappa et al., 2018)

sxc¹/sxc⁶ transheterozygotes die at pharate adult stage.

Expressing sxc^Scer\UAS.cMa under the control of Scer\GAL4^tub.PU partially rescues the lethality of sxc¹/sxc⁶ transheterozygotes and although the majority of the surviving adults have normal wings, a significant proportion has wings with an ectopic vein; these surviving females have viable progeny.

Expressing either sxc^{H537A.Scer\UAS} or sxc^{H596F.Scer\UAS} under the control of Scer\GAL4^tub.PU partially rescues the lethality of sxc¹/sxc⁶ transheterozygotes but the majority of the surviving adults has wing defects which consist mostly of ectopic veins; the rest have normal wing morphology; these surviving females have viable progeny.

Expressing sxc^{D955A.Scer\UAS} under the control of Scer\GAL4^tub.PU partially rescue the lethality of sxc¹/sxc⁶ transheterozygotes but the majority of surviving adults show wing defects, including ectopic veins, notches and blistering; the progeny of sxc^{D955A.Scer\UAS}-rescued sxc¹/sxc⁶ females dies before reaching second larval instar (crossed with either sxc^{D955A.Scer\UAS}-rescued sxc¹/sxc⁶ males) or adulthood (crossed with wild-type males) due to maternal effect.

(Mariappa et al., 2015)

Embryos derived from sxc¹/sxc⁰²⁶³⁷ females expressing sxc^Scer\UAS.cSa under the control of Scer\GAL4^da.G32 show a dramatic reduction in the hatching rate compared to controls at 34[o]C.

(Radermacher et al., 2014)

Flies transheterozygous for sxc¹ and sxc⁶ or sxc⁷ develop into pharate adults showing a typical sxc mutant phenotype.

sxc²/sxc¹ flies are viable and fertile, but exhibit wing abnormalities suggestive of wing-to-haltere transformations.

(Gambetta et al., 2009)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Homozygous adults exhibit homeotic transformation of antenna to first leg, of second and third legs to first leg, of wing to haltere and of abdominal segments A1, A4 and A5 to A2, A5 and A6, respectively. Homozygotes derived from homozygous female germ line exhibit transformation of larval thoracic and abdominal segments toward A8.

(Lindsley and Zimm, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sxc[+]/sxc¹ is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

sxc[+]/sxc¹ is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

sxc[+]/sxc¹ is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

NOT Enhancer of

Statement

Reference

sxc¹ is a non-enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

NOT Suppressor of

Statement

Reference

sxc¹ is a non-suppressor of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

sxc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

sxc[+]/sxc¹, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

sxc[+]/sxc¹ is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

sxc[+]/sxc¹ is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Enhancer of

Statement

Reference

sxc¹ is a non-enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

NOT Suppressor of

Statement

Reference

sxc¹ is a non-suppressor of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Other

Statement

Reference

sxc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

sxc[+]/sxc¹, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

No significant modification of the number of sex combs is seen in sxc¹/+ corto⁴²⁰/+ double heterozygotes compared to sxc¹/+ single heterozygotes.

(Lopez et al., 2001)

Double heterozygotes with trx^B11 show T3 to T2 transformations.

(Gildea et al., 2000)

Has little or no effect on the phenotype of E2f^GMR.PD Dp^GMR.PD BacA\p35^GMR.PH flies.

(Staehling-Hampton et al., 1999)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Some enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of sxc¹.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sxc⁶

(Gambetta et al., 2009)

sxc⁷

(Gambetta et al., 2009)

Partially rescued by

sxc⁶/sxc¹ is partially rescued by Scer\GAL4^Tub.PU/sxc^UAS.cMa

(Mariappa et al., 2015)

sxc⁶/sxc¹ is partially rescued by Scer\GAL4^Tub.PU/sxc^H537A.UAS

(Mariappa et al., 2015)

sxc⁶/sxc¹ is partially rescued by sxc^H596F.UAS/Scer\GAL4^Tub.PU

(Mariappa et al., 2015)

sxc⁶/sxc¹ is partially rescued by sxc^D955A.UAS/Scer\GAL4^Tub.PU

(Mariappa et al., 2015)

Not rescued by

sxc⁶/sxc¹ is not rescued by Scer\GAL4^Tub.PU/sxc^K872M.UAS

(Mariappa et al., 2015)

sxc⁶/sxc¹ is not rescued by sxc^N948I.UAS/Scer\GAL4^Tub.PU

(Mariappa et al., 2015)

Comments

(Mariappa et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (3)

3058

106810

101559

sxc¹ bw¹ speck¹ / SM5

Notes on Origin

Discoverer

Ingham.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sxc¹

(Gildea et al., 2000)

sxc(Ogt)¹

(Radermacher et al., 2014)

sxc¹

(Akan et al., 2021, Pravata et al., 2019, Mariappa et al., 2018, Akan et al., 2016, Mariappa et al., 2015, Radermacher et al., 2014, Mariappa et al., 2011, Gambetta et al., 2009, Gambetta et al., 2009, Sinclair et al., 2009, Sinclair et al., 2009, Hirose et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (26)

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