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General Information
Symbol
Dmel\SxlM4
Species
D. melanogaster
Name
FlyBase ID
FBal0016710
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
SxlM#4
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a 1.4kb hopper element into the male specific exon 3 of Sxl. The insertion splits the exon into 135bp and 60bp segments. The direction of transcription of the hopper element with respect to Sxl is unknown.

2 kb insert near male-specific exon 3.

Insert stated as cause: undefined Insertion of 1.7kb DNA into Sxl, approximately 8-9kb distal to the site of P-element insertion in SxlfPb.

Insertion components
hopper{}SxlM4
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The SxlM alleles differ in their ability to bypass the X:A signal. SxlM4 is more effective than SxlM3, is more effective than SxlM1, at suppressing female-specific zygotic lethality of sisA and scsisB mutations.

SxlM4/X ; traunspecified/traunspecified larvae have gonads that are indistinguishable from XX ; traunspecified/traunspecified larvae. SxlM4/X ; traunspecified/traunspecified adult pseudomales often have degenerating cells in the testes. Germ cells in these flies can be either oogenic or spermatogenic (a single animal contains only oogenic or spermatogenic testes, not both).

XY germ cells carrying SxlM4 are spermatogenic in female host gonads.

Female sterility can be suppressed by SxlM4. Hemizygous male lethality is not suppressed by snf1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

SxlM4 has lethal | male phenotype, non-suppressible by bbflex-2

Suppressor of
Statement
Reference

SxlM4/SxlM4 is a suppressor of partially lethal - majority die | female | heat sensitive phenotype of Df(1)sc19/scsisB-2

SxlM4/SxlM4 is a suppressor of lethal | female | heat sensitive phenotype of Df(1)sc19/scsisB-3

SxlM4 is a suppressor of lethal | female phenotype of sisA1/Df(1)N71

SxlM4 is a suppressor of lethal | female phenotype of sisA2/sisA1

NOT Suppressor of
Statement
Reference

SxlM4 is a non-suppressor of lethal | recessive | female phenotype of sisA2

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/vir3

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/vir4

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/vir5

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/vir6

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/vir7

SxlM4 is a non-suppressor of lethal | female | larval stage phenotype of virunspecified/virts

Other
Statement
Reference
Phenotype Manifest In
NOT Suppressor of
Statement
Reference

SxlM4 is a non-suppressor of ovary phenotype of ovoD1rv23

SxlM4 is a non-suppressor of ovary phenotype of ovoD1rv22

Additional Comments
Genetic Interactions
Statement
Reference

SxlM4, dmP0/dmP0 females are fully viable. While a SxlM4/+ background rescues the female-specific lethality of dmP0, it does not rescue the dmP0 bristle or female sterility phenotypes. No SxlM4, dmP0/dmP0 males are recovered from the cross.

Viable SxlM4 bbflex-2 double mutant males have not been recovered.

87% of SxlM4 ; hhts2/hhAC ovarioles contain multi-chambered cysts.

FlyBase curator comment: subsequent publication (FBrf0134557) calls into question the validity of the genetic interaction between bbflex-2 and SxlM alleles (SxlM1 and SxlM4) stated in FBrf0111803. The suppression of the male lethality by bbflex-2 is slightly temperature dependent with fewer males surviving at 29oC than at 25oC. The resulting males are viable and fertile with no evidence of transformation.

Ovaries of ovoD1rv23/ovoD1rv22 females contain germline chambers in less than 20% of cases. The phenotype is not affected if the females are also carrying SxlM4.

The daughters of females with homozygous vir6 germ line clones are rescued if the daughters carry SxlM4; SxlM4/+ ; vir6/+ animals develop as normal females. SxlM4/+ ; vir6/vir2f animals derived from females carrying homozygous vir6 germ line clones mated to vir2f/+ males survive, but are sexually transformed. Does not rescue the lethality of embryos derived from females with homozygous vir3 or vir4 germ line clones mated to vir+ males.

The presence of SxlM4 failed to rescue female lethality in vir transheterozygotes. vir2f/vir- males are lethal in the presence of SxlM4.

Suppresses the dominant female lethality of Sxlf1 and SxlfP7B0 in embryos derived from snfe8H mothers.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Can partially suppress sexual transformation of germ cells in otu mutant ovaries.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (21)