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General Information
Symbol
Dmel\UbxC1
Species
D. melanogaster
Name
FlyBase ID
FBal0017451
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
C1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Caused by aberration
Cytology
Nature of the lesion
Statement
Reference

Internal deletion (Rowe, EMBO J. 7: 1107--1114). UbxC1 chromosome makes hybrid RNA, 5' exons of the abd-A transcription unit joined to the 3' exons of the Ubx transcription unit.

A deletion with breakpoints in introns of Ubx and abd-A producing a hybrid abd-A-Ubx product (Rowe, EMBO J. 7:1107--1114 , Casanova, EMBO J. 7:1097--1105 ).

Deletion of part of the Ubx and abd-A genes, resulting in a hybrid gene.

Encodes a fusion protein with its amino terminus derived from abd-A and its carboxyl terminus derived from Ubx, giving it weak activity of both genes.

A deletion of parts of the Ubx and abd-A genes, which results in a fusion gene formed by the remaining parts of Ubx and abd-A.

Deletion of approximately 100kb DNA within the Ubx and abd-A regions of the bithorax complex. The proximal breakpoint is within the Ubx transcription unit at -51kb within an intron (coordinates as in FBrf0040194 and FBrf0042053). This deletes the Ubx promoter, the major 5' coding region and one of the two microexons, but leaves the second microexon and the 3', homeobox-containing exon intact. The distal breakpoint is within a 20kb intron of abd-A, 2-2.5kb from the last exon of the 5' cluster. This deletes the 3' cluster of abd-A exons which encode the homeobox and carboxy-terminal regions of the abd-A protein.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Double mutants of UbxC1 and exd have an additive phenotype.

Homozygous larvae have transformed abdominal segments; A1 shows a thoracic pattern (which is probably metathoracic but is difficult to discriminate from mesothoracic) as indicated by the denticle size, the presence of ventral pits and fully developed Keilin's organs. A2-A8 show a mixture of thoracic and abdominal pattern elements, with a gradient from A2 (mostly thoracic) to A8 (mostly abdominal). Hemizygous larvae have a more extreme phenotype; A1 and A2 develop a complete thoracic pattern, and A3-A8 have more thoracic features than in homozygotes. Ventral pits and defective Keilin's organs are present down to A7 in both homo- and hemizygous larvae. Heterozygotes have slightly enlarged halteres and differentiate some bristles in the anterior margin, and frequently have a partial transformation of wing territory to haltere and partial transformation of A1 to a more posterior phenotype.

In homozygous embryos A1 is thoracic with Keilin's organs and ventral pits (resembling T2 more closely than T3 - contrasts with the results in FBrf0063361). A2 to A4 show clear abdominal characteristics, with the denticle morphology becoming progressively more like that of the normal A2/A4 type more posteriorly. Ventral pits are present on all abdominal segments from A1 to A7. A2 to A7 are more 'thoracic' in hemizygotes than in homozygotes.

In homozygotes the first and second abdominal segments show thoracic characteristics, and the ventral denticles of the more posterior abdominal segments resemble those of the first abdominal segment.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Ubx provides the carboxyl end of protein and homeobox. The product is now under the control of the Ubx regulatory elements.

Complementation and phenotypic analysis indicates that UbxC1 retains partial Ubx activity. The developmental properties of the UbxC1 appear to be a mixture of those of Ubx and abd-A. UbxC1 is derepressed in esc- embryos.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)