Ubx1/Ubx9.22 transheterozygous embryos show a significant increase in the proportion of mitotic neuroblast daughter cells, but not mitotic neuroblasts, only in the A1 ventral nerve cord segment, as compared to controls.
The anterior pair of Malpighian tubules do not migrate past the developing midgut in Ubx9.22 mutant embryos.
Homozygous Ubx9.22 mutant embryos fail to develop the 2-3 most anterior pairs of alary muscles.
Ubx9.22 clones within the haltere do not grow larger than their twin spots.
The P compartment of Ubxpbx-1/Ubx9.22 haltere discs is increased in size relative to the disc, such that the P:A size ration is 1.45. This effect is not seen in Ubx9.22/+ discs.
In stage-15 Ubx9.22 mutant embryos the lymph gland is expanded posteriorly into the abdominal segments.
Homozygous embryos frequently show a range of defects in dorsal vessel development, including incomplete dorsal migration of the cardiac precursors and minor morphological defects of the dorsal vessel, but there is still a clear distinction between the heart and the aorta in these animals.
The aorta does not differentiate normally, particularly in the anterior region, in mutant embryos. Pericardiac cells are also disorganised in several positions, particularly in the anterior segments.
When heterozygous with UbxHC71-1.HC166D.Dup.Rec.ry+ the notum reduction phenotype is much more penetrant and severe. These animals also show an enlargement of the haltere, with anterior bristles, characteristic of a weak bx transformation.
Haltere enlarged, average bristle number 0.9 (+-0.9 (SD); N=138).
No gross morphological defects are seen in the central nervous system of Ubx9.22 Abd-BM1 double mutant embryos.
Embryos lack the precursor for ventral muscle 26 in A1 and A2.
Transformation of capitellum to wing.
Elevated levels of ae transcript are found in parasegment 6.
Homozygous embryos have a set of extra leg discs, a rudimentary wing disc and two new sets of spiracles.
The phenotype of fu41 Ubx9.22 double mutants can be interpreted as an addition of the corresponding single mutant phenotypes.
Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.
A2-A4 denticle belts are transformed into thoracic belts, and A5-A8 denticle belts are modified, having much more marked thoracic features in hemizygous embryos.
Homozygotes complete embryogenesis and occasionally survive as third instar larvae. They have the characteristic Ubx phenotype of transformed denticle belts and three pairs of anterior spiracles. In Ubx61d/Ubxbxd-100 larvae A1 is transformed to T3, and a pair of presumptive leg neuromeres is formed in this transformed segment. In Ubx9.22/Ubxbxd-100 adults the commissures of the CNS in parasegment 6 are transformed to resemble those of parasegment 5.
The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubx9.22.