FB2025_01 , released February 20, 2025
Allele: Dmel\vg21
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General Information
Symbol
Dmel\vg21
Species
D. melanogaster
Name
FlyBase ID
FBal0017874
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
P{}vg21
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Silber et al., 1993)
Mutagen
PM hybrid dysgenesis
(Staveley et al., 1994, Williams et al., 1988)
P-element activity
(Williams and Bell, 1988)
Progenitor genotype
Associated Insertion(s)
P{}vg21
Cytology
Description

Insertion of a P-element which has a deletion of bases 382-2603 but is otherwise identical to a full P-element.

(Anderson et al., 2006)

A P-element is inserted in the first intron of the vg transcription unit, not 5' to the start of vg transcription as previously thought. The insertion site is 423bp downstream of the vg transcription start site and the P-element has an internal deletion of nucleotides 381-2601. Transcription of the P-element is in the same orientation as that of vg.

(Hodgetts and O'Keefe, 2001)

vg transcription unit is fused to the P-element insert transcript.

(Staveley and Bell, 1995)

Internally deleted P-element (5' breakpoint at nucleotide position 380 and 3' breakpoint at nucleotide position 2602) inserted in the 5' untranscribed region of vg.

(Staveley et al., 1995)

Insertion of a 687bp P-element just upstream of the putative transcription start site, the 3' end is 20bp upstream of the first exon, in the same orientation as Ddc transcription.

(Heslip and Hodgetts, 1994)

Internally deleted P-element inserted in the 5' untranscribed region of vg.

(Staveley et al., 1994)

Insertion of 7kb of unknown DNA at position 0 on the molecular map of the vg region (Williams, Mol. Gen. Genet. 221: 8).

(Silber et al., 1993)

0/7kb P-element insertion just upstream of the putative transcription start site.

(Heslip et al., 1992)

P-element insertion near the 5' end of the vg transcription unit.

(Williams et al., 1990)

650bp P element insert.

(Williams and Bell, 1988)

P-element insertion at coordinate 0.

(Williams et al., 1988)

insert hybridizing to P sequences at 0kb ; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990).

Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
S78364
S78366
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cryptic allele; homozygotes show no wing defect.

      vg21/Df(2R)vg-B animals show slight nicking of the wing.

      (Anderson et al., 2006)

      Mutant phenotype shows cytotype-dependent expression. Heterozygotes with vg2a33 show moderate wing nicking. Homozygotes: wild type wing phenotype. Heterozygotes with Df(2R)vg-B in M cytotype: moderate wing phenotype. Heterozygotes with Df(2R)vg-B in cytotype: wild type wing phenotype.

      (Hodgetts and O'Keefe, 2001)

      Homozygotes have a wild type phenotype but a strap wing phenotype when in combination with most strong alleles of vg and in hemizygotes, a cryptic phenotype.

      (Staveley et al., 1995)

      Homozygotes have a wild type phenotype and when heterozygous with a strong vg allele individuals have nicked or scalloped wings.

      (Staveley et al., 1994)

      Homozygotes display high resistance to aminopterin.

      (Silber et al., 1993)

      Homozygotes display complete wing margins or only slight nicks at the distal tip of one wing.

      (Heslip et al., 1992)

      "Wild type" phenotype, therefore a cryptic allele. vg1/vg21 heterozygotes exhibit a weak vg phenotype.

      (Williams and Bell, 1988)

      Homozygotes have a wild type phenotype, P-cytotype has no effect on the phenotype but the M-cytotype cause a moderate vg phenotype.

      (Williams et al., 1988)

      cytotype-dependent allele; homozygote normal; weak vg over vg1

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Df(2R)vg-B/vg21 has visible phenotype, suppressible | partially by P\TSal

      (Anderson et al., 2006)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(2R)vg-B/vg21 has wing phenotype, suppressible | partially by P\TSal

      (Anderson et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The presence of P\TSal partially suppresses the nicking of the wing that is seen in vg21/Df(2R)vg-B animals.

      (Anderson et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      ?, 1988.

      Comments
      Comments

      "of vg." was stated as revision.

      (Hodgetts and O'Keefe, 2001)

      Fusion of vg transcript to P-element transcript may be the reason for the cytotype dependence of the vg phenotype.

      (Staveley and Bell, 1995)

      Transposase induced revertants demonstrate that deletions in the 3' region of the P-element result in a strong vg phenotype and deletions in the 5' region result in a revertant phenotype.

      (Staveley et al., 1995)
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vg21
      (Anderson et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)