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General Information
Symbol
Dmel\wsp1
Species
D. melanogaster
Name
spotted
FlyBase ID
FBal0018302
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
wsp, sp-w
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a roo element into the 5' regulatory region.

roo insertion in 5' regulatory region.

roo insertion at nucleotide position +4922.

roo insertion into 5' regulatory region.

Insertion of a roo element in the 5' regulatory region.

Insertion of a roo element into the 5' cis-acting regulatory sequences of w.

Insertion of roo element at +4922.

roo insertion in 5' regulatory region.

roo insertion in the 5' cis regulatory region.

roo insertion at nucleotide position -1170.

Insertion of a 9.2 kb roo-element at map position +4.9 relative to the transcription start site of w.

roo insertion within the w locus.

The wsp1 region has been cloned (Zachar and Bingham, 1982) and sequenced (O'Hare, Murphy, Levis and Rubin, 1984); it is located 1.0-1.9 kb upstream from the 5' end of the start of w+ transcription (Zachar and Bingham, 1982; O'Hare, Levis and Rubin, 1983). wsp1 shows sequence homology and behavior analogous to enhancer sequences (Davison, Chapman, Wedeen and Bingham, 1985). The lesions responsible for wsp1, wsp2 and wsp4 have been analyzed by sequencing cloned portions of these alleles; the breakpoints of wsp3 and wsp81d have also been established by molecular methods. wsp1 carries roo; the other alleles are molecular deletions. Sensitivity to the effect of su(wsp) on eye pigmentation is deleted by wsp81d but not by wsp3 (Davison, Chapman, Wedeen and Bingham, 1985). 8.7 kb insertion map site (kb): +4.92; Origin = insertion of wa copia; '-' values to left (telomere) end; '+' values to right (centromere) end. In spite of the variegated pattern of spots in the eye in this mutant, the transcript is like that of w+ in size, structure and amount (Levis et al., 1984; Pirrotta and Brockl, 1984).

Insertion components
roo{}wsp1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eye pigmentation is reduced in pharate adults.

Homozygous males are darker than homozygous females. Triple X metafemale individuals homozygous for wsp1 exhibit a lighter eye colour than wsp1 homozygous XX females.

Eye colour: uniformly coloured as wsp1/we59; darker than either homozygous wsp1 or homozygous we59 females.

Testis colour: pigmentation enhanced.

Eye colour: relatively light, non-uniform distribution of eye colour.

Eye colour: homogenous brown, with w1. Eye colour: homogenous brown, with wch. Eye colour: homogenous brown, with wa.

Eye colour: white, as wa wsp1. Eye colour: pale yellow, as wch wsp1. Eye colour: like wsp1 when heterozygous with w-.

Eye colour: yellowish to brown; fine-grained mottling; male darker than female. Eye colour: yellow, in females with z1, and two synapsed copies of wsp1 in trans (or tandemly repeated). Malpighian tubule colour: wild-type. Affects that deposition of the eye pigments, resulting in a variegated phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

wsp1 has abnormal eye color phenotype, enhanceable by zv77h

wsp1 has abnormal eye color phenotype, enhanceable by z1

wsp1, zv77h has abnormal eye color phenotype, enhanceable by Taf91

wsp1, z1 has abnormal eye color phenotype, enhanceable by Taf91

wsp1, zv77h has abnormal eye color phenotype, enhanceable by e(y)21

wsp1, zv77h has abnormal eye color phenotype, enhanceable by e(y)34

wsp1, z1 has abnormal eye color phenotype, enhanceable by e(y)34

wsp1, zop6 has abnormal eye color phenotype, enhanceable by e(y)34

wsp1, zop6R1 has abnormal eye color phenotype, enhanceable by e(y)34

NOT Enhanced by
Statement
Reference

wsp1, z1 has abnormal eye color phenotype, non-enhanceable by e(y)21

Suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

wsp1 has phenotype, enhanceable by Ufo1

wsp1 has phenotype, enhanceable by Wowunspecified

wsp1 has phenotype, enhanceable by Wowunspecified/Low1

wsp1 has phenotype, enhanceable by Low1/Pcf11EMS2

wsp1 has phenotype, enhanceable by Wowunspecified/Ufo1

wsp1 has phenotype, enhanceable by Ufo1/MowEMS

wsp1 has phenotype, enhanceable by Wowunspecified/MowEMS/Pcf11EMS2

wsp1 has pigment cell phenotype, enhanceable by RpLP001544

wsp1 has phenotype, enhanceable by Wowγb

wsp1 has phenotype, enhanceable by Wowγe

wsp1 has phenotype, enhanceable by Wowems1

wsp1 has phenotype, enhanceable by Wowhd1

wsp1 has phenotype, enhanceable by Taf91

wsp1 has phenotype, enhanceable by e(y)34

wsp1 has pigment cell phenotype, enhanceable by zv77h

wsp1 has pigment cell phenotype, enhanceable by z1

wsp1, zv77h has pigment cell phenotype, enhanceable by Taf91

wsp1, z1 has pigment cell phenotype, enhanceable by Taf91

wsp1, zv77h has pigment cell phenotype, enhanceable by e(y)21

wsp1, zv77h has pigment cell phenotype, enhanceable by e(y)34

wsp1, z1 has pigment cell phenotype, enhanceable by e(y)34

wsp1, zop6 has pigment cell phenotype, enhanceable by e(y)34

wsp1, zop6R1 has pigment cell phenotype, enhanceable by e(y)34

wsp1 has phenotype, enhanceable by Dp(2;Y)J64

NOT Enhanced by
Statement
Reference

wsp1 has phenotype, non-enhanceable by Kr-h105208

wsp1 has phenotype, non-enhanceable by Pcf11EMS2

wsp1 has phenotype, non-enhanceable by Low1

wsp1 has phenotype, non-enhanceable by Wowunspecified/Pcf11EMS2

wsp1 has phenotype, non-enhanceable by MowEMS/Low1

wsp1 has phenotype, non-enhanceable by Wowunspecified/Low1/Pcf11EMS2

wsp1 has phenotype, non-enhanceable by MowEMS/Low1/Pcf11EMS2

wsp1 has phenotype, non-enhanceable by In(3)Msu1

wsp1 has phenotype, non-enhanceable by In(3)Msu2

wsp1 has phenotype, non-enhanceable by Rm62D

wsp1 has phenotype, non-enhanceable by Rm62Dem

wsp1 has phenotype, non-enhanceable by Rm62E

wsp1 has phenotype, non-enhanceable by Rm62F

wsp1 has phenotype, non-enhanceable by Rm62H

wsp1 has phenotype, non-enhanceable by Rm62K

wsp1, z1 has pigment cell phenotype, non-enhanceable by e(y)21

wsp1 has phenotype, non-enhanceable by Ts(YLt;3Lt)B141

wsp1 has phenotype, non-enhanceable by E(wa)1

Suppressed by
Statement
Reference

wsp1 has eye | pharate adult stage phenotype, suppressible by east1/east1

wsp1 has eye | pharate adult stage phenotype, suppressible | partially by su(w[sp])[+]/east1

wsp1 has eye | pharate adult stage phenotype, suppressible | partially by easthop-7/east[+]

wsp1 has phenotype, suppressible by MowEMS/Pcf11EMS2

wsp1 has phenotype, suppressible by Wowunspecified/MowEMS

wsp1 has phenotype, suppressible by Wowunspecified/MowEMS/Low1

wsp1 has phenotype, suppressible by MowEMS

wsp1 has pigment cell phenotype, suppressible by Rga[+]/Rga03834

wsp1 has pigment cell phenotype, suppressible by eastR63

wsp1 has phenotype, suppressible by Ufo1

wsp1 has phenotype, suppressible by Mowgamma

wsp1 has phenotype, suppressible by Ts(YLt;3Rt)R128

wsp1 has phenotype, suppressible by east1

NOT suppressed by
Statement
Reference

wsp1 has phenotype, non-suppressible by Kr-h105208

wsp1 has phenotype, non-suppressible by Pcf11EMS2

wsp1 has phenotype, non-suppressible by Low1

wsp1 has phenotype, non-suppressible by Wowunspecified/Pcf11EMS2

wsp1 has phenotype, non-suppressible by MowEMS/Low1

wsp1 has phenotype, non-suppressible by Wowunspecified/Low1/Pcf11EMS2

wsp1 has phenotype, non-suppressible by MowEMS/Low1/Pcf11EMS2

wsp1 has phenotype, non-suppressible by In(3)Msu1

wsp1 has phenotype, non-suppressible by In(3)Msu2

wsp1 has phenotype, non-suppressible by Rm62D

wsp1 has phenotype, non-suppressible by Rm62Dem

wsp1 has phenotype, non-suppressible by Rm62E

wsp1 has phenotype, non-suppressible by Rm62F

wsp1 has phenotype, non-suppressible by Rm62H

wsp1 has phenotype, non-suppressible by Rm62K

wsp1 has phenotype, non-suppressible by Ts(YSt;2Lt)B110+Ts(YSt;2Rt)R15

wsp1 has phenotype, non-suppressible by Ts(YSt;3Lt)G48+Ts(YSt;3Rt)R36

wsp1 has phenotype, non-suppressible by Ts(YSt;2Lt)D20+Ts(YSt;2Rt)L138

wsp1 has phenotype, non-suppressible by Ts(YSt;2Lt)L23+Ts(YSt;2Rt)R155

wsp1 has phenotype, non-suppressible by Ts(YLt;2Lt)R14+Ts(YSt;2Rt)L110

wsp1 has phenotype, non-suppressible by Ts(YSt;2Lt)H149+Ts(YSt;2Rt)R14

wsp1 has phenotype, non-suppressible by Ts(YSt;2Rt)L107+Ts(YSt;2Lt)P59

wsp1 has phenotype, non-suppressible by Ts(YLt;3Lt)B141

wsp1 has phenotype, non-suppressible by Ts(YLt;3Lt)A31+Ts(YLt;3Rt)G122

wsp1 has phenotype, non-suppressible by Pcf11γb

wsp1 has phenotype, non-suppressible by Pcf11γc

wsp1 has phenotype, non-suppressible by Pcf11γd

wsp1 has phenotype, non-suppressible by Pcf11EMS3

wsp1 has phenotype, non-suppressible by Pcf11EMS4

wsp1 has phenotype, non-suppressible by Pcf11EMS5

wsp1 has phenotype, non-suppressible by Pcf11hd1

wsp1 has phenotype, non-suppressible by Pcf11γsc

wsp1 has phenotype, non-suppressible by mw2

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Eye pigmentation of wsp1 animals is restored to almost wild type levels in east1 or easthop-7 homozygotes, or east1/easthop-7 transheterozygotes. wsp1 eye pigmentation is rescued to intermediate levels in east1 or easthop-7 heterozygotes.

Transheterozygotes with su(wsp)R63 have more red eye pigment than wsp1 flies.

No interaction with mutations of Rm62.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (2)
Stocks (4)
Notes on Origin
Discoverer

Showell, 1944.

Comments
Comments

Located proximal to wch and distal to wDZL.

Frequency of reversion of the 8.7kb roo insertion in both somatic tissue and the germline after larval exposure to three different alkylating agents, EMS, ENU and MMS, is analysed. The mutagens used did not induce excision of roo, the revertant phenotypes obtained are due to second site modifiers acting on w expression.

Shows hyper-dosage compensation.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (6)
References (54)