FlyBase Allele Report: Dmel\zip[1]

Mutant embryos show alterations in epithelial wound repair compared to wild type. An actomyosin purse string is not assembled at the leading edge of the wound. The edges of the wound are irregular, with actin accumulated in patches that extend over a few cells and particularly at cell-cell junctions, but never forming the thick continuous cable that encircles wounds in wild-type embryos. The wounds heal, but with a severe delay, especially in the contraction phase. Wound closure is achieved by actin-rich cellular protrusions, which are increased in number in the mutant embryos compared to wild type. The reduction of the wound area occurs in jumps, as protrusions pull the wound closed by capturing protrusions from adjacent or opposing cells.

(Abreu-Blanco et al., 2012)

The mitochondria in the neurons of heterozygous zip¹ adult brains are markedly elongated compared to controls.

(Duboff et al., 2012)

Zygotic mutants for zip¹ are embryonic lethal and display a prominent dorsal hole due to failed dorsal closure.

(David et al., 2010)

Expression of a single copy of zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E results in a wing vein expansion phenotype in 82% of wings. The penetrance of this phenotype is slightly decreased (to 72%) in a zip¹/+ background.

Expression of a single copy of zip^{DN.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E in a zip¹/+ background results in lethality.

Expression of a single copy of zip^{HMM.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E in a zip¹/+ background results in a wing vein expansion phenotype in 41% of wings.

Expression of a single copy of zip^Rod.Scer\UAS under the control of Scer\GAL4^en-e16E in a zip¹/+ background results in loss of posterior compartment tissue in 100% of wings.

Expression of a single copy of zip^{Rod.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E in a zip¹/+ background results in a more severe phenotype than expression in a wild-type background.

(Franke et al., 2010)

Mutant embryos show a reduced level of cell intercalation at the segment boundary during dorsal closure (in the abdominal segments of wild-type embryos at the end of dorsal closure, a mixer cell moves across the segment boundary from the anterior compartment to the posterior compartment and two cells from the ventral ectoderm intercalate into the leading edge, posterior to the mixer cell).

(Gettings et al., 2010)

zip³/zip¹ embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17.

zip⁴/zip¹ embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17.

zip²/zip¹ embryos show laterality defects in the proventriculus and anterior midgut. The laterality of the other parts of the embryonic gut, including the hindgut and the posterior part of the midgut is normal in these mutants. The proventriculus and the anterior midgut do not rotate (as in wild-type) in these mutants at stages 15 to 17.

(Okumura et al., 2010)

zip¹/zip² stage 16 embryos have longer dorsal trunks than normal.

(Chung et al., 2009)

Single cell clones of zip¹ exhibit an increased apical cell area. Adherens junctions in multiple cell clones are intact.

(Warner and Longmore, 2009)

zip¹ mutant embryos, neither myosin nor actin accumulates tightly around the invagination edge; instead they form aggregates. In zip¹ mutants, the small group of cells that initiate apical constriction is not observed, and tracheal cells form a large cavity during invagination.

(Brodu and Casanova, 2006)

The eye phenotype of rok^cat.GMR flies is suppressed in a zip¹/+ background.

zip¹/+ partially suppresses the wing phenotype of animals expressing rok^cat.Scer\UAS under the control of Scer\GAL4^en-e16E.

(Verdier et al., 2006)

zip¹ stage 15 larvae show a range of denticle phenotypes. In the mildest phenotype, larvae show cuticle shaping defects and have slightly misaligned denticle rows. The moderate phenotype, which has the highest penetrance, consists of a reduced denticle field that is ovoid in shape, misaligned denticle rows and shortened denticles. In the most severe phenotype, denticles are missing altogether.

The ventral epidermis of stage 15 zip¹ embryos show shaping defects of the actin protrusions that precede the formation of denticles. These protrusions are broad at the base, and are more elongated and wavy than those in wild-type embryos. Additionally, the protrusions are often not positioned at the posterior edge of denticle field primordium cells.

(Walters et al., 2006)

zip¹/zip² embryos show a dorsal closure phenotype with low penetrance. In transgenic mosaic embryos in which some cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^e22c in a zip¹/zip² background, leading-edge cells that do not express zip^{FL.Scer\UAS.T:Avic\GFP} cannot maintain tension and are stretched by neighbouring zip^{FL.Scer\UAS.T:Avic\GFP} expressing cells. The length of contiguous regions of Scer\GAL4^e22c>zip^{FL.Scer\UAS.T:Avic\GFP} expressing leading-edge cells along the supracellular purse string decrease in length over time, indicative of contraction. In contrast, non zip^{FL.Scer\UAS.T:Avic\GFP}-expressing contiguous regions fail to contract, increasing in length over time. In transgenic mosaic embryos in which some cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW in a zip¹/zip² background, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP} expressing leading-edge cells that contact Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP} expressing amnioserosa cells are severely contracted, and the scalloped morphology of the early leading edge is enhanced. In contrast, when non-expressing leading-edge cells contact non-expressing amnioserosa cells the leading edge cells fail to contract and become stretched. When non-expressing leading-edge cells contact Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing amnioserosa cells, leading-edge cells show some contraction. Finally, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing cells show some contraction when they contact non-expressing amnioserosa cells, although this is to a lesser extent than when both cell types express zip^{FL.Scer\UAS.T:Avic\GFP}. Nonexpressing leading-edge cells fail to incorporate into the canthus and cause inward progression of the canthus to stall. These nonexpressors never get fully incorporated into the seam - instead, a small gap is formed when zipping fails and closure bypasses the nonexpressing cells to initiate a new seam. In contrast, Scer\GAL4^sqh.PW>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing cells are incorporated into each canthus at a similar and nearly constant rate. In transgenic mosaic embryos in which some amnioserosa cells express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^c381 in a zip¹/zip² background, nonexpressing amnioserosa cells fail to contract apically and remain rounded. These cells do show an apical shape change at later stages but this may be due to forces generated by surrounding Scer\GAL4^c381>zip^{FL.Scer\UAS.T:Avic\GFP}-expressing amnioserosa cells and the approaching lateral-epidermis sheet. Embryos that express zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E in a zip¹/zip² background display stripe-alignment defects in 65% of cases. Expression of zip^{DN.Scer\UAS.T:Avic\GFP}, under the control of Scer\GAL4^en-e16E, in a zip¹/+ background causes stripe misalignments in 52% of embryos, while only 4% of zip¹/+ embryos show this phenotype without transgene expression.

(Franke et al., 2005)

Mutant embryos exhibit defects in germ band elongation.

(Bertet et al., 2004)

Unlike in wild-type, deep metameric furrow persist ventrally in zip¹ embryos until well into stage 15.

(Larsen et al., 2003)

zip¹ homozygous and zip¹/zip^IIX62 embryos exhibit dramatic defects in head involution. 8% of zip¹ homozygous embryos and 58% of zip¹/zip^IIX62 embryos have a clear dorsal hole. The remaining embryos complete dorsal closure, although they frequently show puckering or segment misalignments along the closed midline seam. During dorsal closure the leading edge in zip¹/zip^IIX62 embryos is very disporganized and extends a broader extent of lamellipodial and filopodial protrusions per unit length of leading edge than wild-type. The total protrusive area of leading edge cells in zip¹/zip¹ embryos is up to 300% greater than wild-type. Filopodia extended by these cells often coalesce into lamellipodia. The cytoskeletal architecture typical of the leading edge during dorsal clonsure in wild-type embryos is lost in zip¹ homozygotes.

(Jacinto et al., 2002)

zip¹/Df(2R)ES1 transheterozygous mutant embryos the muscle VA3 is missing from each segment and VA1 and VA2 are often both not present in each segment.

(Bloor and Kiehart, 2001)

Homozygous embryos do not complete head involution. The salivary glands appear wild-type. Malpighian tubules are abnormal, remaining coiled near their juncture with the hindgut rather than extending anteriorly as in the wild-type. The diameter of the Malpighian tubules is similar to wild-type. The hindgut appears normal and the midgut constrictions appear substantially similar to wild-type. Abnormalities in the peripheral nervous system cannot be detected.

(Blake et al., 1998)

Embryos exhibit defects in dorsal closure and head involution. Labial lobes fail to migrate or fuse ventrally. Labial sensory organs remain external and become ectopic external sensory organs.

(Pederson et al., 1996)

Embryos fail to complete dorsal closure as the mutant myosin fails to contribute sufficient myosin to drive dorsal closure to completion.

(Young et al., 1993)

The nervous system develops abnormally in homozygotes, with brain tissue located more anteriorly and being larger than normal in the fully developed embryo. It is partially surrounded by the cuticle which never encloses the brain completely. The lateral fascicles of different abdominal segments do not respect segment boundaries in a variable manner. Sensory neurons of the gnathal sensory organs remain in the position of the progenitor cells, and their axons fasiculate in a single, thick axon bundle. Homozygous embryos also have an abnormal cuticle pattern.

(Zhao et al., 1988)

strong allele showing severe cuticular and neurological defects

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

zip[+]/zip¹ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

zip[+]/zip¹ is an enhancer of abnormal neuroanatomy phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

zip[+]/zip¹ is an enhancer of visible phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

zip¹ is an enhancer of abnormal cytokinesis phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.UAS}

(Echard and O'Farrell, 2003)

zip¹ is an enhancer of abnormal cell polarity phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

zip[+]/zip¹ is an enhancer of visible | heat sensitive phenotype of fz^I.hs

(Winter et al., 2001)

zip[+]/zip¹ is an enhancer of visible | recessive phenotype of dsh¹

(Winter et al., 2001)

Suppressor of

Statement

Reference

zip¹/zip¹ is a suppressor | partially of visible | adult stage phenotype of Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Jun et al., 2023)

zip¹/zip¹ is a suppressor | partially of melanotic necrosis | adult stage phenotype of Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Jun et al., 2023)

zip[+]/zip¹ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip¹ is a suppressor | partially of decreased size | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip¹ is a suppressor of visible | adult stage phenotype of Scer\GAL4^lz-gal4, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip¹ is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^nub-AC-62, yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

zip[+]/zip¹ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^nub-AC-62, yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

zip[+]/zip¹ is a suppressor | partially of some die during embryonic stage phenotype of step^KG09493/step^k08110

(West et al., 2017)

zip[+]/zip¹ is a suppressor of abnormal cell migration phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

zip[+]/zip¹ is a suppressor of some die during pharate adult stage phenotype of aurA^IM, sqh^E20.E21

(Moon and Matsuzaki, 2013)

zip[+]/zip¹ is a suppressor | partially of abnormal cell polarity | recessive | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

zip[+]/zip¹ is a suppressor of visible phenotype of flw¹, puc^A251.1F3/puc[+]

(Kirchner et al., 2007)

zip¹ is a suppressor of lethal phenotype of Pp1α-96A^GS11179/Df(3R)crb87-5, flw¹

(Kirchner et al., 2007)

zip[+]/zip¹ is a suppressor of visible phenotype of Rok^cat.GMR

(Verdier et al., 2006)

zip¹ is a suppressor of visible phenotype of MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

zip¹ is a suppressor of lethal | male phenotype of flw⁶

(Vereshchagina et al., 2004)

zip¹ is a suppressor of lethal | male phenotype of flw^G0172

(Vereshchagina et al., 2004)

NOT Suppressor of

Statement

Reference

zip[+]/zip¹ is a non-suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub-AC-62, yki^{UAS.cXa.Tag:FLAG}

(Xu et al., 2018)

Other

Statement

Reference

Csk^GD9345, zip¹ has lethal phenotype

(Rudrapatna et al., 2014)

Dpse\l(2)gl^+t12.2, zip²/zip¹ has lethal | embryonic stage phenotype

(Franke et al., 2005)

E(br)121^Ebr121, zip[+]/zip¹ has visible | dominant phenotype

(Ward et al., 2003)

E(br)121^Ebr121/E(br)121[+], zip¹ has visible phenotype

(Ward et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

zip¹ has embryonic/first instar larval cuticle phenotype, enhanceable by aPKC^k06403

(David et al., 2010)

zip¹ has embryonic/first instar larval cuticle phenotype, enhanceable by par-6^Δ226

(David et al., 2010)

zip²/zip¹ has embryo | dorsal closure stage phenotype, enhanceable by Dpse\l(2)gl^+t12.2

(Franke et al., 2005)

NOT Enhanced by

Statement

Reference

aPKC^k06403, zip¹ has embryonic/first instar larval cuticle phenotype, non-enhanceable by par-6^Δ226

(David et al., 2010)

par-6^Δ226, zip¹ has embryonic/first instar larval cuticle phenotype, non-enhanceable by aPKC^k06403

(David et al., 2010)

Enhancer of

Statement

Reference

zip¹ is an enhancer of myoblast phenotype of kirre^rP298-G4

(Kim et al., 2015)

zip[+]/zip¹ is an enhancer of adult brain phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

zip[+]/zip¹ is an enhancer of mitochondrion phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Duboff et al., 2012)

zip[+]/zip¹ is an enhancer of embryonic/first instar larval cuticle phenotype of baz⁴

(David et al., 2010)

zip[+]/zip¹ is an enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

zip[+]/zip¹ is an enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Saja et al., 2010)

zip[+]/zip¹ is an enhancer of wing hair | increased number phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

zip¹ is an enhancer of wing phenotype of MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

zip¹ is an enhancer of wing hair | increased number phenotype of Scer\GAL4^Bx-MS1096, pbl^{ΔDH497-549.UAS}

(Echard and O'Farrell, 2003)

zip¹ is an enhancer of ommatidium phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

zip[+]/zip¹ is an enhancer of wing hair | increased number phenotype of fz^I.hs

(Winter et al., 2001)

zip[+]/zip¹ is an enhancer of wing hair | increased number phenotype of dsh¹

(Winter et al., 2001)

Suppressor of

Statement

Reference

zip¹/zip¹ is a suppressor | partially of eye phenotype of Hsap\CHMP2B^Intron5.UAS, Scer\GAL4^GMR.PF

(Jun et al., 2023)

zip[+]/zip¹ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip¹ is a suppressor | partially of wing phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

zip[+]/zip¹ is a suppressor | partially of wing phenotype of Scer\GAL4^nub-AC-62, yki^{UAS.Tag:FLAG,Tag:Myr(Src64B)}

(Xu et al., 2018)

zip[+]/zip¹ is a suppressor | partially of head | embryonic stage phenotype of step^KG09493/step^k08110

(West et al., 2017)

zip[+]/zip¹ is a suppressor | partially of embryonic epidermis phenotype of step^KG09493/step^k08110

(West et al., 2017)

zip[+]/zip¹ is a suppressor of wing disc phenotype of Csk^GD9345, Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

dia[+], zip[+], dia⁵, zip¹ is a suppressor of embryo | embryonic stage 5 phenotype of Scer\GAL4^{VP16.mat.αTub67C}, step^HMS00365

(Lee and Harris, 2013)

dia[+], zip[+], dia⁵, zip¹ is a suppressor of furrow canal phenotype of Scer\GAL4^{VP16.mat.αTub67C}, step^HMS00365

(Lee and Harris, 2013)

zip[+]/zip¹ is a suppressor | partially of eye phenotype of Scer\GAL4^arm.PS, aurA^IM, aurA^UAS.cWa

(Moon and Matsuzaki, 2013)

zip[+]/zip¹ is a suppressor of eye phenotype of Rok^UAS.cMa, Scer\GAL4^GMR.PU

(Moon and Matsuzaki, 2013)

zip[+]/zip¹ is a suppressor of eye phenotype of Rok^{S119A.S129A.S307A.UAS}, Scer\GAL4^GMR.PU

(Moon and Matsuzaki, 2013)

zip[+]/zip¹ is a suppressor of eye phenotype of Rok^{S753A.S908A.UAS}, Scer\GAL4^GMR.PU

(Moon and Matsuzaki, 2013)

zip[+]/zip¹ is a suppressor | partially of oocyte | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

zip[+]/zip¹ is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Fiehler and Wolff, 2008)

zip[+]/zip¹ is a suppressor of wing phenotype of flw¹, puc^A251.1F3/puc[+]

(Kirchner et al., 2007)

zip[+]/zip¹ is a suppressor of eye phenotype of Rok^cat.GMR

(Verdier et al., 2006)

zip[+]/zip¹ is a suppressor | partially of crossvein phenotype of Rok^cat.UAS.cVa, Scer\GAL4^en-e16E

(Verdier et al., 2006)

zip[+]/zip¹ is a suppressor of eye disc | somatic clone phenotype of Mbs^T541

(Lee and Treisman, 2004)

zip[+]/zip¹ is a suppressor of eye phenotype of Rac1^GMR.PN

(Tan et al., 2003)

zip[+]/zip¹ is a suppressor of mitotic domain 1 | embryonic cycle 14 phenotype of CycB^+t10

(Ji et al., 2002)

NOT Suppressor of

Statement

Reference

zip[+]/zip¹ is a non-suppressor of wing phenotype of Scer\GAL4^nub-AC-62, yki^{UAS.cXa.Tag:FLAG}

(Xu et al., 2018)

zip[+]/zip¹ is a non-suppressor of embryo | embryonic stage 5 phenotype of Scer\GAL4^{VP16.mat.αTub67C}, step^HMS00365

(Lee and Harris, 2013)

zip[+]/zip¹ is a non-suppressor of furrow canal phenotype of Scer\GAL4^{VP16.mat.αTub67C}, step^HMS00365

(Lee and Harris, 2013)

zip¹/zip¹ is a non-suppressor of embryonic epidermis phenotype of Scer\GAL4^en-e16E, dia^{CA.UAS.Tag:HA}

(Homem and Peifer, 2008)

zip¹/zip¹ is a non-suppressor of amnioserosa phenotype of Scer\GAL4^c381, dia^{CA.UAS.Tag:HA}

(Homem and Peifer, 2008)

zip[+]/zip¹ is a non-suppressor of aster | embryonic cycle 5 phenotype of CycB^+t10

(Ji et al., 2002)

zip[+]/zip¹ is a non-suppressor of aster | embryonic cycle 6 phenotype of CycB^+t10

(Ji et al., 2002)

zip[+]/zip¹ is a non-suppressor of aster | embryonic cycle 7 phenotype of CycB^+t10

(Ji et al., 2002)

zip[+]/zip¹ is a non-suppressor of mitotic domain 1 | embryonic cycle 10 phenotype of CycB^+t10

(Ji et al., 2002)

Other

Statement

Reference

ena^C14-06, zip[+]/zip¹ has gonad | embryonic stage phenotype

(Sano et al., 2012)

E(br)121^Ebr121, zip[+]/zip¹ has leg phenotype

(Ward et al., 2003)

E(br)121^Ebr121, zip¹ has leg phenotype

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for zip¹ partially suppresses the increased lethality, "head hole" phenotype and epidermal rosette-like structures during germband retraction, observed in step^KG09493/step^k08110 transheterozygous embryos.

(West et al., 2017)

zip¹ enhances the myoblast fusion defects seen in kirre^rP298 mutant embryos.

zip¹ enhances the myoblast fusion defects seen in kirre^rP298 mutant embryos. In contrast to the round and dense morphology seen in wild type, the F-actin enriched-structures between unfused fusion-competent myoblasts and miniature myotubes are irregularly shaped and exhibit abnormally long protrusions.

(Kim et al., 2015)

A zip¹ heterozygous mutant background suppresses the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing Csk^GD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4^ptc-559.1.

(Rudrapatna et al., 2014)

Maternal heterozygosity for zip¹ does not suppress the furrow canal expansion phenotype seen in embryos derived from mothers expressing step^HMS00365 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}.

Maternal heterozygosity for both dia⁵ and zip¹ suppresses the furrow canal expansion phenotype seen in embryos derived from mothers expressing step^HMS00365 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}.

(Lee and Harris, 2013)

A zip¹ heterozygous background suppresses the small, rough eye phenotype found upon expression of rok^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PU.

A zip¹ heterozygous background suppresses the small, rough eye phenotype found upon expression of rok^{S119A.S129A.S307A.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

A zip¹ heterozygous background suppresses the small, rough eye phenotype found upon expression of rok^{S753A.S908A.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Moon and Matsuzaki, 2013)

51.9% of gonads fail to compact properly in ena^C14-06/+, zip¹/+ transheterozygous embryos, compared to 33.3% in zip¹/+ single heterozygotes.

(Sano et al., 2012)

Expression of psidin^Scer\UAS.cKa under the control of Scer\GAL4^slbo.2.6 in a zip¹ heterozygous background has little or no effect on border cell migration.

(Kim et al., 2011)

One copy of zip¹ partially suppresses the oocyte polarity defects seen when the posterior follicle cells are mutant for flw^FP41.

(Sun et al., 2011)

aPKC^k06403, zip¹ double mutants display a prominent dorsal hoe merged with a large head hole indicating enhancement of the zip¹ embryonic phenotype. par-6^Δ226, zip¹, aPKC^k06403 triple mutants show similar enhancement.

par-6^Δ226, zip¹ double mutants display a prominent dorsal hoe merged with a large head hole indicating enhancement of the zip¹ embryonic phenotype. par-6^Δ226, zip¹, aPKC^k06403 triple mutants show similar enhancement.

zip¹/+ enhances the baz⁴ embryonic phenotype, generating merged dorsal head holes and ventral holes.

(David et al., 2010)

A zip¹/+ background enhances the visual system degeneration seen in Scer\GAL4^GMR.PF, Ppt1^Scer\UAS.cKa flies.

(Saja et al., 2010)

The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of zip¹.

(Chung et al., 2007)

The wing defects seen in flw¹/Y ; puc^A251.1F3/+ flies are suppressed to wild type by zip¹/+.

(Kirchner et al., 2007)

The mislocalization of photoreceptors in Mbs^T541 clones is suppressed when eye discs have a zip¹/+ background.

(Lee and Treisman, 2004)

The amount of blistering and crumpling of wings in flies expressing MYPT-75D^{F117A.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 is suppressed by zip¹.

(Vereshchagina et al., 2004)

S^48-5/zip¹ mutants show 19.34%+-7.06 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

The small, rough eye phenotype of Rac1^GMR.PN flies is partially suppressed by heterozygosity for zip¹.

(Tan et al., 2003)

The fraction of flies showing a malformed leg phenotype in at least one leg, for zip¹ in double heterozygous combination with one of the following alleles is - Sb^Ebr20 : 0%, Sb^Ebr48 : 0%, Sb^Ebr228 : 0%, Sb^Ebr448 : 1%, Sb^Ebr536 : 0%, Sb^Ebr623 : 0%, Rho1^Ebr233 : 2%, Rho1^Ebr246 : 6%, bs^Ebr292 : 0%, E(br)24^Ebr24 : 11%, E(br)65^Ebr65 : 2%, E(br)155^Ebr155 : 1%, E(br)165^Ebr165 : 6%, E(br)333^Ebr333 : 3%, E(br)72^Ebr72 : 1%, E(br)121^Ebr121 : 32%, E(br)160^Ebr160 : 1%, E(br)187^Ebr187 : 0%, E(br)420^Ebr420 : 2% and E(br)444^Ebr444 : 1%.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

One copy of zip¹ enhances the increase in mitochondria length seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^elav.PU.

(Duboff et al., 2012)

Expression of two copies of Dpse\l(2)gl^+t12.2 raises the penetrance of the zip¹/zip² failed dorsal closure phenotype to 100%. Ubiquitous overexpression of zip^{FL.Scer\UAS.T:Avic\GFP}, under the control of the Scer\GAL4^sqh.PW, rescues dorsal closure in more than 84% of zip¹/zip²; Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 embryos. 61% of these rescued flies survive to hatch as larvae, 41% survive to pupal stages and 2.8% eclose as adults. Expression of zip^{FL.Scer\UAS.T:Avic\GFP} in the epidermis and a few amnioserosa cells, driven by Scer\GAL4^e22c, rescues the zip¹/zip²; Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 dorsal closure phenotype in 88% of embryos. Rescued flies survive to larval stages in 60% of cases and to pupal stages in 21% of cases, although no flies eclose. Expression of zip^{FL.Scer\UAS.T:Avic\GFP} in the amnioserosa, driven by Scer\GAL4^c381, rescues the dorsal closure phenotype of Dpse\l(2)gl^+t12.2/Dpse\l(2)gl^+t12.2 mutants in 82% of embryos. However, none of the rescued embryos survive to larval stages. Similarly, when zip^{FL.Scer\UAS.T:Avic\GFP} expression is driven in the leading edge by Scer\GAL4^LE, dorsal closure is rescued in 87% of embryos, but only 1% of flies survive to larval stages. zip^{FL.Scer\UAS.T:Avic\GFP} expression in epidermal stripes, driven by Scer\GAL4^en-e16E, rescues dorsal closure in only half of embryos and does not rescue lethality.

(Franke et al., 2005)

Complementation and Rescue Data

Rescued by

zip²/zip¹ is rescued by zip^{SA2.Ubi-p63E.Tag:MYC}

(Su and Kiehart, 2001)

zip²/zip¹ is rescued by zip^{SD2.Ubi-p63E.Tag:MYC}

(Su and Kiehart, 2001)

Partially rescued by

zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^FL.UAS.GFP

(Franke et al., 2010)

zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^FL.UAS.GFP

(Franke et al., 2007)

zip²/zip¹ is partially rescued by zip^{R1171C.UAS.GFP}/Scer\GAL4^sqh.PW

(Franke et al., 2007)

zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^{D1430N.UAS.GFP}

(Franke et al., 2007)

zip²/zip¹ is partially rescued by zip^{D1847K.UAS.GFP}/Scer\GAL4^sqh.PW

(Franke et al., 2007)

zip²/zip¹ is partially rescued by Scer\GAL4^sqh.PW/zip^{R1939X.UAS.GFP}

(Franke et al., 2007)

zip¹ is partially rescued by zip^UAS.mGFP6/Scer\GAL4^{VP16.mat.αTub67C}

(Barros et al., 2003)

Not rescued by

zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^HMM.UAS.GFP

(Franke et al., 2010)

zip²/zip¹ is not rescued by zip^DN.UAS.GFP/Scer\GAL4^sqh.PW

(Franke et al., 2010)

zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^Rod.UAS

(Franke et al., 2010)

zip²/zip¹ is not rescued by Scer\GAL4^sqh.PW/zip^Rod.UAS.GFP

(Franke et al., 2010)

Comments

Expression of zip^{FL.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW rescues the embryonic lethality of zip¹/zip² animals. 86 +/- 2% of the rescued animals survive to the pupal stage, but only 6 +/- 7% eclose as adults.

Expression of zip^{R1171C.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW rescues the embryonic lethality of zip¹/zip² animals. 62 +/- 10% of the rescued animals survive to the pupal stage, but only 18 +/- 12% eclose as adults.

Expression of zip^{D1430N.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW rescues the embryonic lethality of zip¹/zip² animals. 72 +/- 5% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage.

Expression of zip^{D1847K.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW rescues the embryonic lethality of zip¹/zip² animals. 85 +/- 12% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage.

Expression of zip^{R1933X.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^sqh.PW rescues the embryonic lethality of zip¹/zip² animals. 85 +/- 4% of the rescued animals survive to the pupal stage, but no animals survive to the adult stage.

(Franke et al., 2007)

Expression of zip^{Scer\UAS.T:Avic\GFP}, driven by Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}, allows 34% of zip¹ mutants to hatch and undergo larval development, instead of dying as embryos.

(Barros et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4199

cn¹ bw¹ speck¹ zip¹/CyO

Kyoto

107626

cn¹ bw¹ speck¹ zip¹/CyO

Notes on Origin

Discoverer

Comments

zip¹ homozygous embryos show a more severe phenotype than zip² homozygous embryos.

(Zhao et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

ID16

(Young et al., 1993)

zip-1

(Gaengel and Mlodzik, 2003)

zip¹

(Jun et al., 2023, Hildebrand et al., 2021, Sechi et al., 2020, Thuveson et al., 2019, Xu et al., 2018, West et al., 2017, Schimizzi et al., 2016, Kim et al., 2015, Kitazawa et al., 2014, Nie et al., 2014, Rudrapatna et al., 2014, Lee and Harris, 2013, Moon and Matsuzaki, 2013, Abreu-Blanco et al., 2012, Duboff et al., 2012, Gault et al., 2012, Sano et al., 2012, Sun et al., 2011, David et al., 2010, Djiane and Mlodzik, 2010, Franke et al., 2010, Gettings et al., 2010, Monier et al., 2010, Okumura et al., 2010, Saja et al., 2010, Chung et al., 2009, Warner and Longmore, 2009, Christensen et al., 2008.9.3, Fiehler and Wolff, 2008, Homem and Peifer, 2008, Rodriguez-Diaz et al., 2008, Todi et al., 2008, Chung et al., 2007, Franke et al., 2007, Kirchner et al., 2007, Kirchner et al., 2007, Brodu and Casanova, 2006, Franke et al., 2006, Verdier et al., 2006, Walters et al., 2006)

zip^1D16

(Kim et al., 2011, Bloor and Kiehart, 2001, Su and Kiehart, 2001, Williams et al., 2001, Pederson et al., 1996)

zip^ID16

(Zhao et al., 1988)

zip^ID

(Tearle and Nusslein-Volhard, 1987)

zip[1]

(Guglielmi et al., 2015)

zpr^1D16

(Silver and Montell, 2001)

Name Synonyms

Secondary FlyBase IDs

References (68)

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