Heterozygous N264-39 flies show mild wing margin notching in the distal region in about half of the wings.
Females heterozygous for N264-39, compared with wild-type, show a reduction in germarium cap cells 7 days after eclosion .
Heterozygous N264-39 wings have a mild notched wing margin, bristle loss, and slight vein thickening near the wing blades.
Stage 13 mutant male embryos have a normal number of somatic gonadal precursor cells. However, the gonads of mutant first instar male larvae lack hub cells.
The number of corpora cardiaca (CC) cells is increased in mutant stage 17 embryos compared to wild type. The CC cell lineage does not develop precociously in the mutant embryos, but multiple gl-positive CC precursors are detectable in the mutant embryos at early stage 11 (in contrast to the pair of single precursor cells seen in wild-type embryos at this stage).
Heterozygotes have a notched wing phenotype.
Zygotic N264-39 mutant embryos display a massive expansion of neuronal cells in the entire ectodermal tissue.
Flies heterozygous for N264-39 have smaller eyes than wild-type flies, but their head capsule appears of normal size.
The number of cap cells and germline stem cells in the ovaries of 2 day old heterozygous females is significantly reduced compared to wild type.
Approximately 36.36% of heterozygous N264-39 flies exhibit a haploinsufficient phenotype of wing notching at the posterior margins.
Heterozygotes show notching of the wing margin at the anterior-posterior border.
Heterozygotes have a nicked wing margin phenotype.
Boundary cells of the hindgut fail to develop in mutant embryos.
The wing-notching phenotype of N264-39 heterozygotes is more severe in flies which also carry one or two copies of EgfrE3 or EgfrE1.
Cause a complex pleiotropic syndrome including perturbations of the chaetae pattern.
Mutation causes overproduction of glioblasts.
Homozygous clones in the eye have a severely disturbed ommatidial pattern, visible as a scar in the eye surface. Ommatidia are larger than wild-type and interommatidial bristles are missing. Each ommatidium contains more retinula cells and fewer pigment cells than wild-type. Each ommatidium contains more receptor cells than normal, and may contain up to 13 receptor cells. Homozygous clones in the cuticle lack all bristles. Homozygous mutant clones in the eye are smaller and less frequent than the corresponding control clones.
Extreme embryonic neurogenic phenotype.
Lethal in combination with Nl1N-ts1 or NAx-tsl at 29oC. Homozygous lethal at 29oC.