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General Information
Symbol
Dmel\RpS6air8
Species
D. melanogaster
Name
FlyBase ID
FBal0030173
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
air8
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P element in 5' untranslated region, 43 bases from the translation start site.

Insertion components
P{}RpS6air8
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryonic and larval development retarded, ring gland, salivary glands, gastric cecae and most imaginal discs fail to reach normal size before late larval lethal phase. Ventral ganglion fails to condense and the brain hemispheres are undersized, and at death, large melanotic tumours resulting from abnormalities in hematopoiesis are present in the body cavity. Source of the hemocytes is a hyperplastic lymph gland, which contain lamellocytes (normally not found in lymph gland) in process of abnormal self encapsulation.

Neoplastic growth and melanotic encapsulation of the lymph glands. Transplanted lymph glands cause melanotic tumour formation and premature host death.

Melanotic tumour formation and lethality are due to the same mutation. Mutations exhibit incomplete penetrance and expressivity of the melanotic tumour phenotype. Small and/or abnormally shaped brain. Garland cells found at the junction of the oesophagus and proventriculus are melanized. Hemizygous males exhibit hypertrophied lymph glands.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

RpS6air8/RpS6[+] is a suppressor of visible phenotype of CycEJP

Phenotype Manifest In
Suppressor of
Statement
Reference

RpS6air8/RpS6[+] is a suppressor of eye phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Dysgenesis-induced revertants of the mutant phenotype have lost the P element from the RpS6 locus.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)