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General Information
Symbol
Dmel\SerD
Species
D. melanogaster
Name
FlyBase ID
FBal0030220
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a 5.5kb Tirant element in the 3' untranslated region of the last exon 81bp downstream of the translational stop codon, resulting in truncation of the Ser RNA eliminating putative RNA degradation signals.

Insertion components
Tirant{}SerD
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes show slight scalloping of the wing blade along the tip and towards the posterior margin.

Heterozygotes exhibit loss of distal wing margin material, phenotype is enhanced in homozygotes. SerBd-3/SerD transheterozygotes exhibit loss of distal wing margin material, similar to SerD heterozygotes.

Heterozygotes show notching of the wing, in particular in between the second and fifth wing veins.

Homozygotes and heterozygotes exhibit scalloping of the wing margin due to cell death during pupal stages.

Hemizygotes and homozygotes are viable. Notches on wing tip between the third and fifth vein. Penetrance and expressivity of phenotype in heterzygotes is slightly affected by temperature: fully penetrant at 18oC and weaker at 28oC.

Heterozygotes have wing notches in the adult: dominant wing-nicking phenotype. SerD/Nnd-1 transheterozygotes display a synergistic phenotype: loss of anterior and posterior wing margins and loss of distal wing blade tissue. SerD/Dp(1;2)51bV76e flies have wild type wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

SerD has visible | dominant phenotype, enhanceable by sdSG29.1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

SerD has wing phenotype, enhanceable by ebiE4

SerD has wing phenotype, enhanceable by fz3unspecified

SerD has wing phenotype, enhanceable by sdSG29.1

SerD has wing phenotype, enhanceable by kuzk01405/kuz1405Rev4

SerD has wing phenotype, enhanceable by hrgP1

Enhancer of
Statement
Reference

SerD is an enhancer of wing phenotype of hrgP1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing notching phenotype seen in SerD/+ animals is enhanced by the addition of ebiE4.

Addition of fz3unspecified to SerD flies enhances the wing notching phenotype seen in these flies. A second copy of fz3unspecified enhances this phenotype further and results in additional posterior margin notching.

sdSG29.1/+ ; SerD/+ flies show an enhancement of wing scalloping with a total loss of sensory bristles along the posterior margin and the loss of some bristles along the anterior margin. Hemizygous sdSG29.1 in combination with SerD/+ results in a deeply scalloped posterior margin. Sensory bristles are completely lost from the posterior margin and there are very few bristles along the anterior margin.

The scalloping of the wing margin seen in SerD/+ heterozygotes is enhanced if the flies also carry kuz1405Rev4/kuzk01405.

hrgP1/hrgP1; SerD/+ flies show synergistic enhancement of the notched wing phenotype, with deeper wing notching than is seen in either hrgP1/hrgP1 or SerD/+ single mutant flies, and loss of most of the first wing vein. The notching is also not restricted to sites between the second and fifth wing vein. The 'delta' phenotype and wing confluence phenotype of Df(3R)Dl-FX3 flies is suppressed by SerD.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

SerD protein has increased stability.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
SerD
Name Synonyms
Secondary FlyBase IDs
    References (15)