FlyBase Allele Report: Dmel\Ser[RX82]

General Information

Symbol

Dmel\Ser^RX82

Species

D. melanogaster

Name

FlyBase ID

FBal0030223

Feature type

allele

Associated gene

Dmel\Ser

Associated Insertion(s)

Carried in Construct

Also Known As

Ser^VX82

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tomlinson and Struhl, 1999, Couso et al., 1995, Speicher et al., 1994, de Celis et al., 1993)

loss of function allele

(Dominguez et al., 2004, Micchelli et al., 1997, de Celis et al., 1996)

Mutagen

X ray

(Speicher et al., 1994, Thomas et al., 1991)

Progenitor genotype

Ser¹

(Speicher et al., 1994, Thomas et al., 1991)

Cytology

Polytene chromosomes normal.

(Speicher et al., 1994)

Description

Deletion of 0.5kb.

(Thomas et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^UAS.cHa, Delta^RevF10

(Zhan et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Walters et al., 2005)

lethal - all die before end of larval stage | recessive

(Speicher et al., 1994)

some die during larval stage | recessive

(Speicher et al., 1994)

visible | somatic clone

(de Celis et al., 1996)

Phenotype Manifest In

actin filament & larval salivary gland

(Haberman et al., 2003)

adult abdominal segment 4

(Walters et al., 2005)

adult abdominal segment 5

(Walters et al., 2005)

adult abdominal segment 6

(Walters et al., 2005)

adult abdominal segment 7

(Walters et al., 2005)

denticle row 3

(Walters et al., 2005)

denticle row 4

(Walters et al., 2005)

embryonic/larval anterior spiracle

(Speicher et al., 1994)

embryonic/larval crystal cell | larval stage (with Df(3R)D605)

(Duvic et al., 2002)

embryonic/larval salivary gland duct

(Haberman et al., 2003)

leg (with Ser^rev6-1)

(Le Borgne et al., 2005)

macrochaeta | ectopic (with Ser^rev6-1)

(Le Borgne et al., 2005)

mouth hook

(Speicher et al., 1994)

papilla of larval anterior spiracle

(Speicher et al., 1994)

procrystal cell | somatic clone

(Lebestky et al., 2003)

salivary gland imaginal ring

(Haberman et al., 2003)

wing

(Jonsson and Knust, 1996, Speicher et al., 1994)

wing (with Ser^rev6-1)

(Le Borgne et al., 2005)

wing blade dorsal compartment | somatic clone

(de Celis et al., 1996)

wing disc

(Speicher et al., 1994)

Detailed Description

Statement

Reference

The number of corpora cardiaca cells is normal in mutant embryos.

(Park et al., 2011)

Clones of cells doubly mutant for Dl^RevF10 and Ser^RX82 are found frequently in the wing disc at any stage of development and do not exhibit obvious phenotypic alterations.

Clones of cells doubly mutant for Dl^RevF10 and Ser^RX82 and also expressing arm^{S10.Scer\UAS.T:Hsap\MYC} via Scer\GAL4^αTub84B.PL (using the MARCM technique) remain integrated in the wing disc epithelium and do not exhibit growth defects.

(Sanders et al., 2009)

Mutants have unsegmented legs.

(Le Borgne et al., 2005)

Ser^RX82 mutants have only one denticle row at the region where rows 3 and 4 are normally present. The row that is present at this site has ambiguous polarity. Stage 14 Ser^RX82 embryos have the same total number of cells across each parasegment that form segments A4-7 as wild-type embryos, with one less row of denticle field cells and one more smooth cell row. This shows that the initial allocation of cells to the denticle field is defective in Ser^RX82 mutants.

(Walters et al., 2005)

In Ser^RX82 homozygous embryos the distal ends of thr salivary gland ducts are enlarged/splayed in the region where they contact the secretory cells. In the salivary glands of Ser^RX82 homozygous second instar larvae, the diploid imaginal ring nuclei are missing: all salivary gland nuclei are large and polytenized. These salivary glands also lack the actin rings that encircle wild-type glands.

(Haberman et al., 2003)

In Ser^RX82 clones in the lymph gland, very few crystal cell precursors are seen, and they are always at the edge of clones.

(Lebestky et al., 2003)

Decreased numbers of crystal cells are seen in Ser^RX82/Df(3R)D605 mutant larvae at late third instar, compared to wild-type.

(Duvic et al., 2002)

Homozygous clones in the eye generally appear wild type and only very rarely cause perturbations in ommatidial polarity.

(Tomlinson and Struhl, 1999)

The number of cells in the nau-expressing muscle precursor clusters is wild-type in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

(Rusconi and Corbin, 1998)

Homozygous clones in the adult scutum have normal bristle structures. Homozygous clones induced in the sensory organ lineage produce normal external bristle structures. Homozygous clones in the wing have no detectable phenotype.

(Zeng et al., 1998)

Ser^RX82/Df(3R)D605 hemizygotes fail to establish an organising centre at the dorsoventral boundary in the wing disc; wings are rudimentary. Scer\GAL4^h-540.3-mediated expression of Ser^Scer\UAS.cSa in second/early third larval instar partially restores wing formation (about half normal length but lack any marginal differentiation).

(Jonsson and Knust, 1996)

Homozygous clones abutting the wing margin in the dorsal wing compartment or induced before dorso-ventral lineage segregation cause extensive wing scalloping.

(de Celis et al., 1996)

Anterior spiracles do not develop knob-like structure typical of first and second larval instar, nor the retractable fingerlike structures characteristic of third instar larvae. The tracheal trunk terminates without opening to the exterior anteriorly, but the posterior spiracles look normal. Mouth hooks always exhibit features characteristic of first instar larvae. Some imaginal discs are smaller than wild type, particularly the dorsal mesothoracic discs. The size of the humeral disc appears normal. Pharate adult escapers are lacking wings and halteres, genital apparatus and anal plates are small or missing, tarsal segments are fused and eyes are rough and reduced. Clones induced in adults are normal in head, thorax legs and abdomen, but produce nicking and deletions in the wing.

(Speicher et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ser[+], Delta^RevF10, Dl[+], Ser^RX82 is an enhancer of abnormal cell number | adult stage phenotype of Pld^UAS.cRa, Scer\GAL4^pnr-MD237

(Medina-Yáñez et al., 2020)

Ser[+]/Ser^RX82 is an enhancer of visible | dominant phenotype of Bx¹

(Milan et al., 2004)

Ser^RX82 is an enhancer of visible phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

Suppressor of

Statement

Reference

Delta^RevF10/Ser^RX82 is a suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Zhan et al., 2013)

Other

Statement

Reference

Delta^RevF10, N^Mcd5, Ser^RX82 has visible | somatic clone phenotype

(Ramain et al., 2001)

Delta^RevF10, Ser^RX82 has visible | recessive phenotype

(Zeng et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Delta^RevF10, Ser[+]/Ser^RX82 has wing vein phenotype, enhanceable by Yif1^doc-16/Yif1[+]

(Kandasamy et al., 2021)

Delta^RevF10, Ser[+]/Ser^RX82 has wing vein phenotype, enhanceable by Yif1^doc-1/Yif1[+]

(Kandasamy et al., 2021)

Suppressed by

Statement

Reference

Ser^RX82 has denticle row 4 phenotype, suppressible by Scer\GAL4^ptc-559.1/rho^UAS.cGa

(Walters et al., 2005)

NOT suppressed by

Statement

Reference

Ser^RX82 has denticle row 3 phenotype, non-suppressible by fng⁸⁰

(Walters et al., 2005)

Ser^RX82 has denticle row 4 phenotype, non-suppressible by fng⁸⁰

(Walters et al., 2005)

Enhancer of

Statement

Reference

Ser[+], Delta^RevF10, Dl[+], Ser^RX82 is an enhancer of external sensory organ | adult stage phenotype of Pld^UAS.cRa, Scer\GAL4^pnr-MD237

(Medina-Yáñez et al., 2020)

Ser[+]/Ser^RX82 is an enhancer of wing margin phenotype of Bx¹

(Milan et al., 2004)

Ser^RX82 is an enhancer of wing margin phenotype of Nsf2^EQ.UAS, Scer\GAL4^bbg-C96

(Stewart et al., 2001)

NOT Enhancer of

Statement

Reference

Ser[+]/Ser^RX82 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, fng^UAS.cKa

(Dominguez et al., 2004)

Suppressor of

Statement

Reference

Ser^RX82 is a suppressor of denticle | ectopic phenotype of fng⁸⁰

(Walters et al., 2005)

Other

Statement

Reference

Delta^RevF10, Ser[+]/Ser^RX82 has wing vein phenotype

(Kandasamy et al., 2021)

Delta^RevF10/Dl[+], Ser[+]/Ser^RX82, cos^H29, hid^GMR.PG has eye phenotype

(Christiansen et al., 2013)

Delta^RevF10, Ser^RX82 has female germline stem cell | germline clone phenotype

(Ward et al., 2006)

Scer\GAL4^ptc-559.1, Ser^RX82, rho^UAS.cGa has denticle row 5 phenotype

(Walters et al., 2005)

Delta^RevF10/Dl[+], Ser^RX82, eyg^M3-12/eyg[+] has eye phenotype

(Chao et al., 2004)

Delta^RevF10/Dl[+], Ser[+]/Ser^RX82, eyg^M3-12 has eye phenotype

(Chao et al., 2004)

Delta^RevF10, Ser[+]/Ser^RX82, eyg^M3-12/eyg[+] has eye phenotype

(Chao et al., 2004)

Ser^RX82, frc^NP0297 has anterior scutellar bristle phenotype

(Goto et al., 2001)

Delta^RevF10, N^Mcd5, Ser^RX82 has microchaeta | somatic clone phenotype

(Ramain et al., 2001)

Delta^RevF10, Ser^RX82 has macrochaeta phenotype

(Zeng et al., 1998)

Delta^RevF10, Ser^RX82 has wing vein phenotype

(Zeng et al., 1998)

Delta^RevF10, Ser^RX82 has scutum & macrochaeta phenotype

(Zeng et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Dl^RevF10, Ser^RX82 double heterozygotes exhibit thickened veins and delta-like wing venation patterns.

(Kandasamy et al., 2021)

Dl^RevF10, Ser^RX82 double mutant clones spanning the A1 fold in larval eye-antennal discs exhibit a failure of epithelial folding of the A1 fold.

(Ku and Sun, 2017)

The suppression of the W^GMR.PG eye phenotype seen in eyes mosaic for cos^H29 (generated using the ey-FLP/FRT system) is abrogated by heterozygosity for both Dl^RevF10 and Ser^RX82.

(Christiansen et al., 2013)

Dl^RevF10, Ser^RX82 mutant germline stem cells differentiate and leave the niche, resulting in an empty germarium phenotype when both germline stem cells are mutant.

(Ward et al., 2006)

Ser^RX82, fng⁸⁰ double mutants show the same denticle row phenotype as Ser^RX82 single mutants, in which a denticle row is missing. Expression of rho^Scer\UAS.cGa, under the control of Scer\GAL4^ptc-559.1, in Ser^RX82 embryos raised at 18 or 22^oC rarely restores proper denticle row 4 polarity. However, raising embryos of the same genotype at 29^oC does restore row 4 polarity and causes an expansion of type 5 denticles posterior to the normal denticle field.

(Walters et al., 2005)

Dl^RevF10, Ser^RX82 transheterozygotes have normal sized eyes, but eyg^M3-12; Dl^RevF10, Ser^RX82 triple heterozygous flies have small eyes.

(Chao et al., 2004)

The small eye phenotype of flies in which fng^Scer\UAS.cKa is expressed under the control of Scer\GAL4^ey.PH is not enhanced in Ser^RX82 heterozygotes.

(Dominguez et al., 2004)

The severity of the Bx¹/+ wing scalloping phenotype is enhanced by one copy of Ser^RX82.

(Milan et al., 2004)

frc^NP0297 in double heterozygous combination with Ser^RX82 results in duplications of the anterior scutellar bristles.

(Goto et al., 2001)

Dl^RevF10,Ser^RX82 double mutant somatic clones in the follicle cells does not lead to any detectable phenotype.

(Lopez-Schier and St. Johnston, 2001)

N^Mcd5 Dl^RevF10 Ser^RX82 triple mutant clones do not develop microchaetae but produce epidermis.

(Ramain et al., 2001)

In Dl^RevF10,Ser^RX82 homozygous embryos derived from Dl^RevF10,Ser^RX82 homozygous female germ-line clones (lacking both maternal and zygotic function), the same MP2 neural phenotype as seen in other Dl alleles alone.

(Rusconi and Corbin, 1999)

Dl^RevF10 Ser^RX82 double mutant clones in the eye behave in the same way as Dl^RevF10 single mutant clones.

(Tomlinson and Struhl, 1999)

Dl^RevF10 Ser^RX82 double homozygous clones on the adult scutum produce epidermal cells but not external bristle structures. Dl^RevF10 Ser^RX82 double homozygous clones induced in the sensory organ lineage frequently have bristles with double shafts (approximately 44% of homozygous macrochaetae have double shafts). Loss of external sensory structures (balding) is also seen. Dl^RevF10 Ser^RX82 double homozygous clones in the wing produce larger and more frequent thickening of the veins compared to single mutant Dl^RevF10 homozygous clones.

(Zeng et al., 1998)

Scer\GAL4^h-540.3-mediated expression of wg^{l-12.Scer\UAS} in Ser^RX82/Df(3R)D605 hemizygous second/early third larval instar fails to rescue the rudimentary wing phenotype.

(Jonsson and Knust, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Ser^RX82/Df(3R)D605 is partially rescued by Scer\GAL4^hry-540.3/Ser^UAS.cSa

(Jonsson and Knust, 1996)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6300

Delta^RevF10 e^* Ser^RX82 P{neoFRT}82B/TM6B, Tb¹

Notes on Origin

Discoverer

Comments

See Thomas et al., 1991, Development 111:749--761 .

(de Celis et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Ser⁸²

(Shi et al., 2026)

Ser^Rx81

(Jonsson and Knust, 1996)

Ser^Rx82

(Schnute et al., 2022, Couturier et al., 2019, Corson et al., 2017, Langridge and Struhl, 2017, Sanders et al., 2009, Walters et al., 2005, Lebestky et al., 2003, Zeng et al., 1998, Speicher et al., 1994)

Ser^VX82

(Babaoglan et al., 2009, Klein, 2003)

Ser^rx82

(Johannes and Preiss, 2002)

ser^Rx82

(Thomas and van Meyel, 2007)

Name Synonyms

Secondary FlyBase IDs

References (56)

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