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General Information
D. melanogaster
FlyBase ID
Feature type
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Key Links
Nature of the Allele
Mutations Mapped to the Genome
Additional Notes
Associated Sequence Data
DNA sequence
Protein sequence

Polytene chromosomes normal.

Nature of the lesion

Deletion of 0.5kb.

Expression Data
Reporter Expression
Additional Information
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
Disease-implicated variant(s)
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description

The number of corpora cardiaca cells is normal in mutant embryos.

Clones of cells doubly mutant for DlRevF10 and SerRX82 are found frequently in the wing disc at any stage of development and do not exhibit obvious phenotypic alterations.

Clones of cells doubly mutant for DlRevF10 and SerRX82 and also expressing armS10.Scer\UAS.T:Hsap\MYC via Scer\GAL4αTub84B.PL (using the MARCM technique) remain integrated in the wing disc epithelium and do not exhibit growth defects.

Mutants have unsegmented legs.

SerRX82 mutants have only one denticle row at the region where rows 3 and 4 are normally present. The row that is present at this site has ambiguous polarity. Stage 14 SerRX82 embryos have the same total number of cells across each parasegment that form segments A4-7 as wild-type embryos, with one less row of denticle field cells and one more smooth cell row. This shows that the initial allocation of cells to the denticle field is defective in SerRX82 mutants.

In SerRX82 homozygous embryos the distal ends of thr salivary gland ducts are enlarged/splayed in the region where they contact the secretory cells. In the salivary glands of SerRX82 homozygous second instar larvae, the diploid imaginal ring nuclei are missing: all salivary gland nuclei are large and polytenized. These salivary glands also lack the actin rings that encircle wild-type glands.

In SerRX82 clones in the lymph gland, very few crystal cell precursors are seen, and they are always at the edge of clones.

Decreased numbers of crystal cells are seen in SerRX82/Df(3R)D605 mutant larvae at late third instar, compared to wild-type.

Homozygous clones in the eye generally appear wild type and only very rarely cause perturbations in ommatidial polarity.

The number of cells in the nau-expressing muscle precursor clusters is wild-type in homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic function).

Homozygous clones in the adult scutum have normal bristle structures. Homozygous clones induced in the sensory organ lineage produce normal external bristle structures. Homozygous clones in the wing have no detectable phenotype.

SerRX82/Df(3R)D605 hemizygotes fail to establish an organising centre at the dorsoventral boundary in the wing disc; wings are rudimentary. Scer\GAL4h-540.3-mediated expression of SerScer\UAS.cSa in second/early third larval instar partially restores wing formation (about half normal length but lack any marginal differentiation).

Homozygous clones abutting the wing margin in the dorsal wing compartment or induced before dorso-ventral lineage segregation cause extensive wing scalloping.

Anterior spiracles do not develop knob-like structure typical of first and second larval instar, nor the retractable fingerlike structures characteristic of third instar larvae. The tracheal trunk terminates without opening to the exterior anteriorly, but the posterior spiracles look normal. Mouth hooks always exhibit features characteristic of first instar larvae. Some imaginal discs are smaller than wild type, particularly the dorsal mesothoracic discs. The size of the humeral disc appears normal. Pharate adult escapers are lacking wings and halteres, genital apparatus and anal plates are small or missing, tarsal segments are fused and eyes are rough and reduced. Clones induced in adults are normal in head, thorax legs and abdomen, but produce nicking and deletions in the wing.

External Data
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of

Ser[+]/SerRX82 is an enhancer of visible | dominant phenotype of Bx1

Suppressor of
Phenotype Manifest In
Suppressed by
NOT suppressed by

SerRX82 has denticle row 3 phenotype, non-suppressible by fng80

SerRX82 has denticle row 4 phenotype, non-suppressible by fng80

Enhancer of

Ser[+]/SerRX82 is an enhancer of wing margin phenotype of Bx1

NOT Enhancer of

Ser[+]/SerRX82 is a non-enhancer of eye phenotype of Scer\GAL4ey.PH, fngUAS.cKa

Suppressor of

SerRX82 is a suppressor of denticle | ectopic phenotype of fng80

Additional Comments
Genetic Interactions

DlRevF10, SerRX82 double mutant clones spanning the A1 fold in larval eye-antennal discs exhibit a failure of epithelial folding of the A1 fold.

The suppression of the WGMR.PG eye phenotype seen in eyes mosaic for cosH29 (generated using the ey-FLP/FRT system) is abrogated by heterozygosity for both DlRevF10 and SerRX82.

DlRevF10, SerRX82 mutant germline stem cells differentiate and leave the niche, resulting in an empty germarium phenotype when both germline stem cells are mutant.

SerRX82, fng80 double mutants show the same denticle row phenotype as SerRX82 single mutants, in which a denticle row is missing. Expression of rhoScer\UAS.cGa, under the control of Scer\GAL4ptc-559.1, in SerRX82 embryos raised at 18 or 22oC rarely restores proper denticle row 4 polarity. However, raising embryos of the same genotype at 29oC does restore row 4 polarity and causes an expansion of type 5 denticles posterior to the normal denticle field.

DlRevF10, SerRX82 transheterozygotes have normal sized eyes, but eygM3-12; DlRevF10, SerRX82 triple heterozygous flies have small eyes.

The small eye phenotype of flies in which fngScer\UAS.cKa is expressed under the control of Scer\GAL4ey.PH is not enhanced in SerRX82 heterozygotes.

The severity of the Bx1/+ wing scalloping phenotype is enhanced by one copy of SerRX82.

frcNP0297 in double heterozygous combination with SerRX82 results in duplications of the anterior scutellar bristles.

DlRevF10,SerRX82 double mutant somatic clones in the follicle cells does not lead to any detectable phenotype.

NMcd5 DlRevF10 SerRX82 triple mutant clones do not develop microchaetae but produce epidermis.

In DlRevF10,SerRX82 homozygous embryos derived from DlRevF10,SerRX82 homozygous female germ-line clones (lacking both maternal and zygotic function), the same MP2 neural phenotype as seen in other Dl alleles alone.

DlRevF10 SerRX82 double mutant clones in the eye behave in the same way as DlRevF10 single mutant clones.

DlRevF10 SerRX82 double homozygous clones on the adult scutum produce epidermal cells but not external bristle structures. DlRevF10 SerRX82 double homozygous clones induced in the sensory organ lineage frequently have bristles with double shafts (approximately 44% of homozygous macrochaetae have double shafts). Loss of external sensory structures (balding) is also seen. DlRevF10 SerRX82 double homozygous clones in the wing produce larger and more frequent thickening of the veins compared to single mutant DlRevF10 homozygous clones.

Scer\GAL4h-540.3-mediated expression of wgl-12.Scer\UAS in SerRX82/Df(3R)D605 hemizygous second/early third larval instar fails to rescue the rudimentary wing phenotype.

Xenogenetic Interactions
Complementation and Rescue Data
Partially rescued by
Images (0)
Stocks (1)
Notes on Origin

See Thomas et al., 1991, Development 111:749--761 .

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (50)