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General Information
Symbol
Dmel\aubQC42
Species
D. melanogaster
Name
FlyBase ID
FBal0030533
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
aubQC
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T11000606R

Amino acid change:

Y94term | aub-PA; Y23term | aub-PC

Reported amino acid change:

Y94term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Y94term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  brain cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos from aubHN2/aubQC42 mothers are completely lethal and frequently display fusion of dorsal appendages.

aubQC42/aubHN2 and aubQC42/aubsting-1 transheterozygotes exhibit crystalline aggregates (of Stellate protein) in spermatocytes, which are absent in aubQC42 single heterozygotes and wild-type controls; aubQC42/aubHN2 transheterozygotes do not display significant changes in the length of third instar larval neuromuscular junctions, as compared to controls.

aubHN2/aubQC42 mutant females exhibit a modest decrease in egg laying capacity (75% of wild type).

aubQC42/+ embryos display the normal number of pole cells.

aubQC42 heterozygotes relieve w silencing in the In(1)wm4 line.

Eggs laid by aubHN2/aubQC42 females have dorsal appendage defects; 52.4% have fused dorsal appendages, 24.5% lack dorsal appendages and 23.1% have wild-type dorsal appendages.

No embryos derived from aubN11/aubQC42 females produce a cuticle.

Eggs laid by aubQC42/aubHN females show a variable ventralised phenotype.

aubHN/aubQC42 eggs show fused dorsal appendages in 40% of cases, no appendages in 12% of cases and the wild-type number of appendages in 48% of cases.

The frequency of P-element excisions (in the M cytotype background) is increased by the presence of aubQC42 in the mother's genotype, compared to controls.

aubQC42 flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

Suppressor of repeat-induced silencing, as seen at heterochromatic tandem arrays of insertions of the P{lacW} transposon.

Perinuclear nuage appears smoother than normal in aubHN/aubQC42 nurse cells, but nuage particles are unaffected.

2% of eggs from homozygous mothers are fertilized and embryos lack abdominal segments and pole cells, i.e. show a classic posterior group mutant phenotype.

Most extreme eggs are spindle shaped without dorsal appendages. Other eggs have fused dorsal appendages or of normal morphology but remain unfertilized.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

aub[+]/aubQC42 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAPSd

aub[+]/aubQC42 is an enhancer of suppressor of variegation phenotype of Atf-2c06407

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

aubQC42 is a suppressor of neoplasia phenotype of l(3)mbtts1

NOT Suppressor of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Enhancer of
Statement
Reference

aub[+]/aubQC42 is an enhancer of abdominal segment phenotype of rump1

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

aubQC42 heterozygosity does not suppress the crystalline aggregates (of Stellate protein) observed in the spermatocytes of Fmr1Δ113M heterozygotes.

CycJnull/Df(3L)Exel6095 (expressing armi+t6.3 to restore armi[+] function) enhances the fertility defects seen in aubHN2/aubQC42 mutant females. The resulting flies lay no eggs and oocyte development is arrested, with egg chambers rarely advancing beyond stage 7-8. Compound egg chambers (multiple cysts in a single follicular epithelium) are seen, and these often include a disorganised layer of follicle cells almost separating two fully developed cysts. This phenotype can be fully suppressed by expression of CycJ+t4.

The segregation distortion seen in males carrying either the SD-5star, SD-LosArenos, SD-72 or SD-Mad-ltcn Dp(2;2)RanGAPSD chromosome variant (in a sensitive Rsp background) is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aubQC42.

The survival of roX1ex33A Df(1)roX2Δ adult males is not significantly altered if they are also heterozygous for aubQC42.

nosBN,nos+1+3.T:MS2\MCP.BS/nosBN embryos carrying a aubQC42/+ mutation display a reduction in abdominal segmentation, forming an average of 2-3 abdominal segments. Mutant embryos display the normal number of pole cells.

rump1 mutant embryos carrying a aubQC42/+ mutation display an increase in the number of embryos that develop less than 8 abdominal segments.

rump1 mutant embryos carrying an aubQC42/+ mutation, and the mutation nosBN, nos+1+3.T:MS2\MCP.BS/nosBN , display an increase in the number of embryos that develop less than 8 abdominal segments.

When Atf-2c06407/+ is combined with aubQC42/+, an additive effect on the derepression of w in In(1)wm4 flies is observed.

The frequency with which l(3)mbtts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is markedly reduced if the transplanted tissue is also homozygous for aubQC42.

The dorsal appendage defects seen in eggs laid by aubHN2/aubQC42 females are suppressed if the females are also homozygous for lokp6; 99.2% of the eggs have wild-type dorsal appendages.

The ventralised phenotype seen in eggs derived from aubQC42/aubHN females is partially suppressed by lokunspecified.

The fused dorsal appendage phenotype of aubHN/aubQC42 eggs is suppressed in lokp6; aubHN/aubQC42 eggs with 98% of double mutants showing wild-type appendage morphology.

The mei-41D3 mutation suppresses the fused dorsal appendage phenotype of aubHN/aubQC42 eggs; 85% of mei-41D3; aubHN/aubQC42 eggs show wild-type appendage morphology.

aubQC42/+ abolishes repression of P-element excision by the P cytotype. This disruption appears to involve a maternal effect, as cytotype-mediated repression of P-element excisions does not occur in offspring whose mothers were heterozygous for aubQC42, even when the offspring do not inherit the aubQC42 mutation themselves. Paternally inherited aubQC42 has no effect on th cytotype system of P-element repression. The aubQC42 mutation only impairs cytotype regulation in the short term as once the mutation has been removed from a line, P-cytotype is quickly reestablished.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

The maternal effect embryonic lethality and dorsal appendages fusion phenotypes characteristic for embryos from aubHN2/aubQC42 mothers are partially rescued by expression of aubScer\UAS.P\T.T:Avic\GFP-m6 but not aubAA.Scer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in the embryos.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (62)