CycJnull/Df(3L)Exel6095 (expressing armi+t6.3 to restore armi[+] function) enhances the fertility defects seen in aubHN2/aubQC42 mutant females. The resulting flies lay no eggs and oocyte development is arrested, with egg chambers rarely advancing beyond stage 7-8. Compound egg chambers (multiple cysts in a single follicular epithelium) are seen, and these often include a disorganised layer of follicle cells almost separating two fully developed cysts. This phenotype can be fully suppressed by expression of CycJ+t4.
The segregation distortion seen in males carrying either the SD-5star, SD-LosArenos, SD-72 or SD-Mad-ltcn Dp(2;2)RanGAPSD chromosome variant (in a sensitive Rsp background) is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aubQC42.
nosBN,nos+1+3.T:MS2\MCP.BS/nosBN embryos carrying a aubQC42/+ mutation display a reduction in abdominal segmentation, forming an average of 2-3 abdominal segments. Mutant embryos display the normal number of pole cells.
The frequency with which l(3)mbtts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is markedly reduced if the transplanted tissue is also homozygous for aubQC42.
aubQC42/+ abolishes repression of P-element excision by the P cytotype. This disruption appears to involve a maternal effect, as cytotype-mediated repression of P-element excisions does not occur in offspring whose mothers were heterozygous for aubQC42, even when the offspring do not inherit the aubQC42 mutation themselves. Paternally inherited aubQC42 has no effect on th cytotype system of P-element repression. The aubQC42 mutation only impairs cytotype regulation in the short term as once the mutation has been removed from a line, P-cytotype is quickly reestablished.
The maternal effect embryonic lethality and dorsal appendages fusion phenotypes characteristic for embryos from aubHN2/aubQC42 mothers are partially rescued by expression of aubScer\UAS.P\T.T:Avic\GFP-m6 but not aubAA.Scer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in the embryos.