T11000606R
Y94term | aub-PA; Y23term | aub-PC
Y94term
Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.
Amino acid replacement: Y94term.
egg chorion (with aubHN2)
aubQC42/aubHN2 and aubQC42/aubsting-1 transheterozygotes exhibit crystalline aggregates (of Stellate protein) in spermatocytes, which are absent in aubQC42 single heterozygotes and wild-type controls; aubQC42/aubHN2 transheterozygotes do not display significant changes in the length of third instar larval neuromuscular junctions, as compared to controls.
aubQC42/+ embryos display the normal number of pole cells.
aubQC42 flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.
Suppressor of repeat-induced silencing, as seen at heterochromatic tandem arrays of insertions of the P{lacW} transposon.
2% of eggs from homozygous mothers are fertilized and embryos lack abdominal segments and pole cells, i.e. show a classic posterior group mutant phenotype.
Most extreme eggs are spindle shaped without dorsal appendages. Other eggs have fused dorsal appendages or of normal morphology but remain unfertilized.
Df(3L)Exel6095/CycJnull, armi+t6.3, aubHN2/aubQC42 has female sterile phenotype, suppressible | partially by CycJ+t4
aubHN2/aubQC42 has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by lokp6/lokp6
aub[+]/aubQC42 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAPSd
aub[+]/aubQC42 is an enhancer of suppressor of variegation phenotype of Atf-2c06407
aub[+]/aubQC42 is a non-enhancer of partially lethal - majority die | male phenotype of Df(1)roX2Δ, lncRNA:roX1ex33A
aubQC42 is a suppressor of neoplasia phenotype of l(3)mbtts1
aubHN2/aubQC42 is a non-suppressor of increased cell death | oogenesis | oogenesis phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of increased cell number | oogenesis | oogenesis phenotype of l(3)mbtGM76/Df(3R)ED10966
aub[+]/aubQC42 is a non-suppressor of partially lethal - majority die | male phenotype of Df(1)roX2Δ, lncRNA:roX1ex33A
Df(3L)Exel6095/CycJnull, armi+t6.3, aubHN2/aubQC42 has female sterile phenotype
aub[+]/aubQC42, rump1 has abdominal segment phenotype, enhanceable by nosBN/nos+1+3.Tag:MS2
Df(3L)Exel6095/CycJnull, armi+t6.3, aubHN2/aubQC42 has egg chamber phenotype, suppressible by CycJ+t4
aubHN2/aubQC42 has dorsal appendage phenotype, suppressible by lokp6/lokp6
aubHN2/aubQC42 has egg chorion phenotype, suppressible | partially by lokunspecified
aubHN2/aubQC42 has dorsal appendage phenotype, suppressible by mei-41D3/mei-41D3
aub[+]/aubQC42 is an enhancer of abdominal segment phenotype of nos+1+3.Tag:MS2, nosBN
aub[+]/aubQC42 is an enhancer of abdominal segment phenotype of rump1
aubQC42 is a suppressor of phenotype of oskbcd.3UTR.Tag:polyHis
aubHN2/aubQC42 is a non-suppressor of ovary phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of ovariole phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of egg chamber phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of female germline cell | increased number phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of nurse cell | increased number phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of oocyte | increased number phenotype of l(3)mbtGM76/Df(3R)ED10966
aubHN2/aubQC42 is a non-suppressor of follicle cell phenotype of l(3)mbtGM76/Df(3R)ED10966
aub[+]/aubQC42 is a non-suppressor of spermatocyte | spermatogenesis phenotype of Fmr1Δ113M
Df(3L)Exel6095/CycJnull, armi+t6.3, aubHN2/aubQC42 has egg chamber phenotype
CycJnull/Df(3L)Exel6095 (expressing armi+t6.3 to restore armi[+] function) enhances the fertility defects seen in aubHN2/aubQC42 mutant females. The resulting flies lay no eggs and oocyte development is arrested, with egg chambers rarely advancing beyond stage 7-8. Compound egg chambers (multiple cysts in a single follicular epithelium) are seen, and these often include a disorganised layer of follicle cells almost separating two fully developed cysts. This phenotype can be fully suppressed by expression of CycJ+t4.
The segregation distortion seen in males carrying either the SD-5star, SD-LosArenos, SD-72 or SD-Mad-ltcn Dp(2;2)RanGAPSD chromosome variant (in a sensitive Rsp background) is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aubQC42.
The survival of roX1ex33A Df(1)roX2Δ adult males is not significantly altered if they are also heterozygous for aubQC42.
nosBN,nos+1+3.T:MS2\MCP.BS/nosBN embryos carrying a aubQC42/+ mutation display a reduction in abdominal segmentation, forming an average of 2-3 abdominal segments. Mutant embryos display the normal number of pole cells.
rump1 mutant embryos carrying a aubQC42/+ mutation display an increase in the number of embryos that develop less than 8 abdominal segments.
rump1 mutant embryos carrying an aubQC42/+ mutation, and the mutation nosBN, nos+1+3.T:MS2\MCP.BS/nosBN , display an increase in the number of embryos that develop less than 8 abdominal segments.
When Atf-2c06407/+ is combined with aubQC42/+, an additive effect on the derepression of w in In(1)wm4 flies is observed.
The frequency with which l(3)mbtts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is markedly reduced if the transplanted tissue is also homozygous for aubQC42.
The ventralised phenotype seen in eggs derived from aubQC42/aubHN females is partially suppressed by lokunspecified.
The fused dorsal appendage phenotype of aubHN/aubQC42 eggs is suppressed in lokp6; aubHN/aubQC42 eggs with 98% of double mutants showing wild-type appendage morphology.
The mei-41D3 mutation suppresses the fused dorsal appendage phenotype of aubHN/aubQC42 eggs; 85% of mei-41D3; aubHN/aubQC42 eggs show wild-type appendage morphology.
aubQC42/+ abolishes repression of P-element excision by the P cytotype. This disruption appears to involve a maternal effect, as cytotype-mediated repression of P-element excisions does not occur in offspring whose mothers were heterozygous for aubQC42, even when the offspring do not inherit the aubQC42 mutation themselves. Paternally inherited aubQC42 has no effect on th cytotype system of P-element repression. The aubQC42 mutation only impairs cytotype regulation in the short term as once the mutation has been removed from a line, P-cytotype is quickly reestablished.
aubHN2/aubQC42 is partially rescued by Scer\GAL4VP16.nos.UTR/aubUASp.mGFP6
aubHN2/aubQC42 is not rescued by Scer\GAL4VP16.nos.UTR/aubAA.UASp.mGFP6
The maternal effect embryonic lethality and dorsal appendages fusion phenotypes characteristic for embryos from aubHN2/aubQC42 mothers are partially rescued by expression of aubScer\UAS.P\T.T:Avic\GFP-m6 but not aubAA.Scer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in the embryos.