FlyBase Allele Report: Dmel\aub[QC42]

General Information

Symbol

Dmel\aub^QC42

Species

D. melanogaster

Name

FlyBase ID

FBal0030533

Feature type

allele

Associated gene

Dmel\aub

Associated Insertion(s)

Carried in Construct

Also Known As

aub^QC

Key Links

Genomic Maps

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Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schupbach and Wieschaus, 1991)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

point_mutation

2L:11,000,606..11,000,606 [-]

Nucleotide change:

T11000606R

Amino acid change:

Y94term | aub-PA; Y23term | aub-PC

Reported amino acid change:

Y94term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Sahin et al., 2016)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Amino acid replacement: Y94term.

(Sahin et al., 2016)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by caz^VDRC.cUa

(Wakisaka et al., 2019)

ameliorates brain cancer

modeled by l(3)mbt^ts1

(Janic et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-fertile (with aub^HN2)

(Atikukke et al., 2014)

female sterile

(Chen et al., 2007, Schupbach and Wieschaus, 1991)

lethal | maternal effect | recessive

(Wilson et al., 1996)

lethal - all die during embryonic stage | maternal effect (with aub^HN2)

(Barckmann et al., 2015, Orsi et al., 2010)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76

(Wang et al., 2014)

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-66

(Wang et al., 2014)

non-suppressor of variegation | dominant, with P{w⁺(-1360)}1250

(Wang et al., 2014)

suppressor of variegation

(Seong et al., 2011, Pal-Bhadra et al., 2004)

suppressor of variegation, with P{T1(-FRT)}T190-177

(Haynes et al., 2006)

suppressor of variegation, with P{T1}T190-177

(Haynes et al., 2006)

suppressor of variegation | dominant, with P{w⁺(FRT.attP.1360)}1250

(Wang et al., 2014)

Phenotype Manifest In

dorsal appendage (with aub^HN2)

(Orsi et al., 2010, Klattenhoff et al., 2007)

dorsal appendage | maternal effect (with aub^HN2)

(Barckmann et al., 2015)

egg chorion (with aub^HN2)

(Chen et al., 2007)

embryo | maternal effect | posterior

(Wilson et al., 1996)

embryonic/larval cuticle | embryonic stage (with aub^N11)

(Rouget et al., 2010)

spermatocyte | spermatogenesis (with aub^HN2)

(Bozzetti et al., 2015)

spermatocyte | spermatogenesis (with aub^sting-1)

(Bozzetti et al., 2015)

Detailed Description

Statement

Reference

Embryos from aub^HN2/aub^QC42 mothers are completely lethal and frequently display fusion of dorsal appendages.

(Barckmann et al., 2015)

aub^QC42/aub^HN2 and aub^QC42/aub^sting-1 transheterozygotes exhibit crystalline aggregates (of Stellate protein) in spermatocytes, which are absent in aub^QC42 single heterozygotes and wild-type controls; aub^QC42/aub^HN2 transheterozygotes do not display significant changes in the length of third instar larval neuromuscular junctions, as compared to controls.

(Bozzetti et al., 2015)

aub^HN2/aub^QC42 mutant females exhibit a modest decrease in egg laying capacity (75% of wild type).

(Atikukke et al., 2014)

Newly eclosed aub^HN2/aub^QC42 transheterozygous females do not show any obvious changes in the number of germ line stem cells in the germarium, as compared to controls.

(Ma et al., 2014)

aub^QC42/+ embryos display the normal number of pole cells.

(Becalska et al., 2011)

aub^QC42 heterozygotes relieve w silencing in the In(1)w^m4 line.

(Seong et al., 2011)

Eggs laid by aub^HN2/aub^QC42 females have dorsal appendage defects; 52.4% have fused dorsal appendages, 24.5% lack dorsal appendages and 23.1% have wild-type dorsal appendages.

(Orsi et al., 2010)

No embryos derived from aub^N11/aub^QC42 females produce a cuticle.

(Rouget et al., 2010)

Eggs laid by aub^QC42/aub^HN females show a variable ventralised phenotype.

(Chen et al., 2007)

aub^HN/aub^QC42 eggs show fused dorsal appendages in 40% of cases, no appendages in 12% of cases and the wild-type number of appendages in 48% of cases.

(Klattenhoff et al., 2007)

The frequency of P-element excisions (in the M cytotype background) is increased by the presence of aub^QC42 in the mother's genotype, compared to controls.

(Simmons et al., 2007)

aub^QC42 flies show a disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

(Haynes et al., 2006)

Suppressor of repeat-induced silencing, as seen at heterochromatic tandem arrays of insertions of the P{lacW} transposon.

(Pal-Bhadra et al., 2004)

Perinuclear nuage appears smoother than normal in aub^HN/aub^QC42 nurse cells, but nuage particles are unaffected.

(Snee and Macdonald, 2004)

2% of eggs from homozygous mothers are fertilized and embryos lack abdominal segments and pole cells, i.e. show a classic posterior group mutant phenotype.

(Wilson et al., 1996)

Most extreme eggs are spindle shaped without dorsal appendages. Other eggs have fused dorsal appendages or of normal morphology but remain unfertilized.

(Schupbach and Wieschaus, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(3L)Exel6095/CycJ^null, armi^+t6.3, aub^HN2/aub^QC42 has female sterile phenotype, suppressible | partially by CycJ^+t4

(Atikukke et al., 2014)

NOT suppressed by

Statement

Reference

aub^HN2/aub^QC42 has lethal - all die during embryonic stage | maternal effect phenotype, non-suppressible by lok^p6/lok^p6

(Orsi et al., 2010)

Enhancer of

Statement

Reference

aub[+]/aub^QC42 is an enhancer of abnormal meiotic cell cycle phenotype of RanGAP^Sd

(Gell and Reenan, 2013)

aub[+]/aub^QC42 is an enhancer of suppressor of variegation phenotype of Atf-2^c06407

(Seong et al., 2011)

NOT Enhancer of

Statement

Reference

aub[+]/aub^QC42 is a non-enhancer of partially lethal - majority die | male phenotype of Df(1)roX2Δ, lncRNA:roX1^ex33A

(Menon and Meller, 2012)

Suppressor of

Statement

Reference

aub^QC42 is a suppressor of neoplasia phenotype of l(3)mbt^ts1

(Janic et al., 2010)

NOT Suppressor of

Statement

Reference

aub^HN2/aub^QC42 is a non-suppressor of increased cell death | oogenesis | oogenesis phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of increased cell number | oogenesis | oogenesis phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub[+]/aub^QC42 is a non-suppressor of partially lethal - majority die | male phenotype of Df(1)roX2Δ, lncRNA:roX1^ex33A

(Menon and Meller, 2012)

Other

Statement

Reference

Df(3L)Exel6095/CycJ^null, armi^+t6.3, aub^HN2/aub^QC42 has female sterile phenotype

(Atikukke et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

aub[+]/aub^QC42, rump¹ has abdominal segment phenotype, enhanceable by nos^BN/nos^+1+3.Tag:MS2

(Becalska et al., 2011)

Suppressed by

Statement

Reference

Df(3L)Exel6095/CycJ^null, armi^+t6.3, aub^HN2/aub^QC42 has egg chamber phenotype, suppressible by CycJ^+t4

(Atikukke et al., 2014)

aub^HN2/aub^QC42 has dorsal appendage phenotype, suppressible by lok^p6/lok^p6

(Orsi et al., 2010)

aub^HN2/aub^QC42 has egg chorion phenotype, suppressible | partially by lok^unspecified

(Chen et al., 2007)

aub^HN2/aub^QC42 has dorsal appendage phenotype, suppressible by lok^p6/lok^p6/lok^p6/lok^p6

(Klattenhoff et al., 2007)

aub^HN2/aub^QC42 has dorsal appendage phenotype, suppressible by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2007)

Enhancer of

Statement

Reference

aub[+]/aub^QC42 is an enhancer of abdominal segment phenotype of nos^+1+3.Tag:MS2, nos^BN

(Becalska et al., 2011)

aub[+]/aub^QC42 is an enhancer of abdominal segment phenotype of rump¹

(Becalska et al., 2011)

Suppressor of

Statement

Reference

aub^QC42 is a suppressor of phenotype of osk^{bcd.3UTR.Tag:polyHis}

(Wilson et al., 1996, Wilson et al., 1996)

NOT Suppressor of

Statement

Reference

aub^HN2/aub^QC42 is a non-suppressor of ovary phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of ovariole phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of egg chamber phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of female germline cell | increased number phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of nurse cell | increased number phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of oocyte | increased number phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub^HN2/aub^QC42 is a non-suppressor of follicle cell phenotype of l(3)mbt^GM76/Df(3R)ED10966

(Coux et al., 2018)

aub[+]/aub^QC42 is a non-suppressor of spermatocyte | spermatogenesis phenotype of Fmr1^Δ113M

(Bozzetti et al., 2015)

Other

Statement

Reference

Df(3L)Exel6095/CycJ^null, armi^+t6.3, aub^HN2/aub^QC42 has egg chamber phenotype

(Atikukke et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

aub^QC42 heterozygosity does not suppress the crystalline aggregates (of Stellate protein) observed in the spermatocytes of Fmr1^Δ113M heterozygotes.

(Bozzetti et al., 2015)

CycJ^null/Df(3L)Exel6095 (expressing armi^+t6.3 to restore armi[+] function) enhances the fertility defects seen in aub^HN2/aub^QC42 mutant females. The resulting flies lay no eggs and oocyte development is arrested, with egg chambers rarely advancing beyond stage 7-8. Compound egg chambers (multiple cysts in a single follicular epithelium) are seen, and these often include a disorganised layer of follicle cells almost separating two fully developed cysts. This phenotype can be fully suppressed by expression of CycJ^+t4.

(Atikukke et al., 2014)

The segregation distortion seen in males carrying either the SD-5star, SD-LosArenos, SD-72 or SD-Mad-ltcn Dp(2;2)RanGAP^SD chromosome variant (in a sensitive Rsp background) is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAP^SD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aub^QC42.

(Gell and Reenan, 2013)

The survival of roX1^ex33A Df(1)roX2Δ adult males is not significantly altered if they are also heterozygous for aub^QC42.

(Menon and Meller, 2012)

nos^BN,nos^{+1+3.T:MS2\MCP.BS}/nos^BN embryos carrying a aub^QC42/+ mutation display a reduction in abdominal segmentation, forming an average of 2-3 abdominal segments. Mutant embryos display the normal number of pole cells.

rump¹ mutant embryos carrying a aub^QC42/+ mutation display an increase in the number of embryos that develop less than 8 abdominal segments.

rump¹ mutant embryos carrying an aub^QC42/+ mutation, and the mutation nos^BN, nos^{+1+3.T:MS2\MCP.BS}/nos^BN , display an increase in the number of embryos that develop less than 8 abdominal segments.

(Becalska et al., 2011)

When Atf-2^c06407/+ is combined with aub^QC42/+, an additive effect on the derepression of w in In(1)w^m4 flies is observed.

(Seong et al., 2011)

The frequency with which l(3)mbt^ts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is markedly reduced if the transplanted tissue is also homozygous for aub^QC42.

(Janic et al., 2010)

The dorsal appendage defects seen in eggs laid by aub^HN2/aub^QC42 females are suppressed if the females are also homozygous for lok^p6; 99.2% of the eggs have wild-type dorsal appendages.

(Orsi et al., 2010)

The ventralised phenotype seen in eggs derived from aub^QC42/aub^HN females is partially suppressed by lok^unspecified.

(Chen et al., 2007)

The fused dorsal appendage phenotype of aub^HN/aub^QC42 eggs is suppressed in lok^p6; aub^HN/aub^QC42 eggs with 98% of double mutants showing wild-type appendage morphology.

The mei-41^D3 mutation suppresses the fused dorsal appendage phenotype of aub^HN/aub^QC42 eggs; 85% of mei-41^D3; aub^HN/aub^QC42 eggs show wild-type appendage morphology.

(Klattenhoff et al., 2007)

aub^QC42/+ abolishes repression of P-element excision by the P cytotype. This disruption appears to involve a maternal effect, as cytotype-mediated repression of P-element excisions does not occur in offspring whose mothers were heterozygous for aub^QC42, even when the offspring do not inherit the aub^QC42 mutation themselves. Paternally inherited aub^QC42 has no effect on th cytotype system of P-element repression. The aub^QC42 mutation only impairs cytotype regulation in the short term as once the mutation has been removed from a line, P-cytotype is quickly reestablished.

(Simmons et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

aub^HN2/aub^QC42 is partially rescued by Scer\GAL4^VP16.nos.UTR/aub^UASp.mGFP6

(Barckmann et al., 2015)

Not rescued by

aub^HN2/aub^QC42 is not rescued by Scer\GAL4^VP16.nos.UTR/aub^{AA.UASp.mGFP6}

(Barckmann et al., 2015)

Comments

The maternal effect embryonic lethality and dorsal appendages fusion phenotypes characteristic for embryos from aub^HN2/aub^QC42 mothers are partially rescued by expression of aub^{Scer\UAS.P\T.T:Avic\GFP-m6} but not aub^{AA.Scer\UAS.P\T.T:Avic\GFP-m6} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in the embryos.

(Barckmann et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4968

w¹¹¹⁸; aub^QC42 cn¹ bw¹/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Aub^QC42

(Wakisaka et al., 2019, Yang et al., 2015)

Aub^QC

(Huang et al., 2021)

aub^QC42

(Lim et al., 2022, Chen et al., 2021, Gebert et al., 2021, Huang et al., 2021, Vrettos et al., 2021, Ramat et al., 2020, Stolyarenko, 2020, Kotov et al., 2019, Coux et al., 2018, Ma et al., 2017, Teixeira et al., 2017, Lo et al., 2016, Sahin et al., 2016, Barckmann et al., 2015, Bozzetti et al., 2015, Molla-Herman et al., 2015, Atikukke et al., 2014, Ma et al., 2014, Wang et al., 2014, Perrat et al., 2013, Menon and Meller, 2012, Pöyhönen et al., 2012, Simmons et al., 2012, Becalska et al., 2011, Kibanov et al., 2011, Pane et al., 2011, Seong et al., 2011, Shpiz et al., 2011, Zamparini et al., 2011, Zhang et al., 2011, Janic et al., 2010, Nagao et al., 2010, Orsi et al., 2010, Rouget et al., 2010, Simmons et al., 2010, Li et al., 2009, Shpiz et al., 2009, Klattenhoff et al., 2007, Pelisson et al., 2007, Simmons et al., 2007, Usakin et al., 2007, Ashraf et al., 2006, Grimaud et al., 2006, Haynes et al., 2006, Vagin et al., 2006, Snee and Macdonald, 2004)

aub^QC

(Eichler et al., 2020, Kina et al., 2019, Ma et al., 2017, Wylie et al., 2014, Gell and Reenan, 2013, Chen et al., 2007, Chen et al., 2007)

aubQC42

(Brennecke et al., 2007)

aubergine^QC

(Huynh et al., 2004)

Name Synonyms

aubergine

(Seong et al., 2011)

Secondary FlyBase IDs

References (67)

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