A small deletion derived from imprecise excision of a P-element removes part of the second exon including the initiator codon for translation and creates an additional exon from the P-element. An upstream portion of the second exon is spliced out upstream of codon 69. The ATG at position 145 is the first possible initiator resulting in an N-terminally truncated protein lacking the first 144 amino acids.
Eggs laid by cactE10/+ females are wild type.
Causes a dorsalised phenotype.
Females homozygous for this allele or heterozygous for this allele and a deficiency for cact generate strongly dorsalized or dorsolateralized embryos. Females transheterozygous for this allele and a loss of function allele result in embryos in which ventral structures are progressively lost at the expense of dorsal structures as the strength of the loss of function allele increases.
cactE10 has lethal | maternal effect phenotype, enhanceable by fus1/fus[+]
cactE10 is a suppressor of abnormal immune response phenotype of lwr5/lwr4-3
cactE8/cactE10 is a suppressor | partially of melanotic mass phenotype | larval stage phenotype of lwr5/lwr4-3
cactE10, lwr5/lwr4-3 has lethal | wandering third instar larval stage phenotype
cactE10, dl[-]/+ has female sterile phenotype
cactE10 has embryonic epidermis phenotype, enhanceable by fus1/fus[+]
cactE10 has embryonic epidermis phenotype, enhanceable by Egfr[+]/fus[+]/Egfrfus/fus2
cactE10 has embryonic epidermis phenotype, enhanceable by dl[+]/dl1
cactE10 has embryonic epidermis phenotype, enhanceable by ea1/ea[+]
cactE10 has embryonic epidermis phenotype, enhanceable by grk3/grk3/grk[+]
cactE10 has embryonic epidermis phenotype, enhanceable by grk6/grk6/grk[+]
cactE10 has embryonic epidermis phenotype, enhanceable by spz[+]/spz4
cactE10, fus[+]/fus2 has embryonic epidermis phenotype, enhanceable by Egfrfus
cactE10 has embryonic epidermis phenotype, enhanceable by fus2
cactE10 has embryonic epidermis phenotype, enhanceable by fus1
cactE10 has embryonic epidermis phenotype, non-enhanceable by fus[+]/fus2
cactE10 has embryonic epidermis phenotype, non-enhanceable by Egfr[+]/Egfrt1
cactE10 has embryonic epidermis phenotype, non-enhanceable by sqdunspecified/sqd[+]
cactE10 is a suppressor of embryonic/larval fat body phenotype of lwr5/lwr4-3
cactE10 is a suppressor of embryonic/larval hemocoel phenotype of lwr5/lwr4-3
cactE8/cactE10 is a non-suppressor of lamellocyte | increased number phenotype of lwr5/lwr4-3
Embryos laid by cactE10/+, dl1/+ females are weakly dorsalized, 90% of embryos produced by cactE10/+, spz4/+ are weakly dorsalized and 50% of embryos produced by cactE10/+, ea1/+ are weakly dorsalized. More than 80% of embryos produced by cactE10/+, fus1/+ are distinctly dorsalized, and the Egfrfus,fus2 chromosome has a similar but stronger effect. Fewer than 10% of embryos produced by cactE10/+, fus1/+ females hatch and 80-90% show the twisted body and head defects characteristic of a loss of mesoderm. Mesodermal cell types are lost.
cactBQ/cactE10 is partially rescued by cactΔ51.αTub67C.lacZ
cactBQ/cactE10 is partially rescued by cactΔ76.αTub67C.lacZ
cactBQ/cactE10 is partially rescued by cactαTub67C.lacZ
cactBQ/cactE10 is partially rescued by cactΔ101.αTub67C.lacZ
cactBQ/cactE10 is partially rescued by cactS74A.S78A.αTub67C.lacZ
cactBQ/cactE10 is partially rescued by cactS74A.S78A.S82A.S83A.αTub67C.lacZ
cactBQ/cactE10 is not rescued by cactΔ100.S116A.αTub67C.lacZ
cactBQ/cactE10 is not rescued by cactΔ125.αTub67C.lacZ
cactBQ/cactE10 is not rescued by cactΔ100.S104A.S116A.αTub67C.lacZ
In trans to dl amorphic alleles, this allele results in dorsalized embryos.