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General Information
Symbol
Dmel\cactE8
Species
D. melanogaster
Name
FlyBase ID
FBal0030706
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The mean circulating hemocyte number of cactE10/cactE8 mutants is not statistically different from that of controls.

The number of circulating hemocytes is increased in cactE8/cact9 third instar larvae compared to wild-type.

The ability of cactE8/cact3 larvae to encapsulate L.boulardi eggs is significantly increased compared to that of control larvae.

cactE8/cact3 larvae are viable at 24 and 48 hours after fertilisation. By 72 hours after fertilisation there is some lethality and delay in the rate of development compared to control siblings. Only 40% of the larvae survive to 120 hours after fertilisation, and only 4% of the larvae make white prepupae. Over 90% of larvae have melanotic capsules. cactE8/cact9 larvae are viable at 24 and 48 hours after fertilisation. More than 80% of the larvae survive to 120 hours after fertilisation and progress into pupal stages. Less than 1% of these animals eclose, the majority dying as pupae. Approximately 40% of larvae have melanotic capsules. cactE10/cactE8 larvae and adults do not have melanotic capsules. Hemocyte density in cactE8/cact3 hemolymph is more than 10-fold higher than in the hemolymph of control or heterozygous larvae. There are an increased number of lamellocytes in the hemolymph compared to control larvae. The lymph glands of 5 to 8 day old animals are abnormally large and there are many more hemocytes per lobe. Hemocyte density in cactE8/cactE10 hemolymph is not significantly different than in the hemolymph of control larvae.

Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

cactE8/cactE10 is a non-suppressor of lamellocyte | increased number phenotype of lwr5/lwr4-3

Additional Comments
Genetic Interactions
Statement
Reference

The melanotic tumour penetrance is reduced in lwr4-3 cactE8/lwr5 cactE10 double mutants compared to lwr4-3/lwr5 single mutants and by day 8, the amount of circulating hemocytes is reduced in the double mutants. In contrast, the amount of lamellocytes remains as high as in the single mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)