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General Information
Symbol
Dmel\dac1
Species
D. melanogaster
Name
FlyBase ID
FBal0031014
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C16484070T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q225term | dac-PA; Q225term | dac-PB; Q225term | dac-PC; Q225term | dac-PD; Q225term | dac-PF; Q225term | dac-PG

    Reported amino acid change:

    Q225term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Nucleotide substitution: C?T.

    Amino acid replacement: Q225term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Although dac1 lamina precursor cells are able to undergo mitosis and are integrated into columns, they fail to express a late neuronal differentiation marker.

    Mutant animals have almost no eye tissue, and small fused legs.

    The mushroom bodies of dac1/dac3 or dac1/Df(2L)dac-4 adults show a number of defects. The α lobes are reduced in size (this phenotype is completely penetrant). Aberrant projections are often seen emanating from the calyx along the peduncle and in the direction of the tips of the α lobes. The medial (β, β' and γ) lobes appear grossly disorganised (this phenotype is completely penetrant). Aberrant projections are often seen emanating from the γ lobe and projections from the heel are occasionally seen in dac1/dac3 adults. The ellipsoid body is severely disorganised in dac1/dac3 adults. Only 3.2% of dac1/dac3 and 8.9% of dac1/Df(2L)dac-4 third instar larvae show a marked reduction in size of the α-type lobe and the defect is frequently unilateral. No aberrant projections are evident from the β-type lobe, the peduncle or the calyx.

    Homozygous adults exhibit severely reduced or no eyes due to failure of the morphogenetic furrow to initiate.

    Eyes of homozygotes are severely reduced and roughened, or absent. Ommatidia have either too many or too few photoreceptors, and the ommatidial array is disrupted. Morphogenetic furrow movement does not occur in about half mutant eye discs, and is dramatically reduced in the rest. Mutants have short, little legs. Femur, tibia and proximal three tarsi are severely condensed. Cell death is increased in mutant leg discs.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    dac1; eyD1Da and dac1; eyJD double heterozygotes have normal mushroom bodies and eyes.

    Modifies the EgfrE3 mutant eye phenotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    dac7C1.Scer\UAS expressed under the control of Scer\GAL4OK107 rescues the mushroom body defects of dac1/dac3 or dac1/Df(2L)dac-4 animals to very close to wild type; the γ lobe shows minor disorganisation. The rescue is temperature dependent (greater rescue at 25oC compared to 18oC). dac21.Scer\UAS expressed under the control of Scer\GAL4OK107 rescues the mushroom body defects of dac1/Df(2L)dac-4 animals to very close to wild type; the γ lobe shows minor disorganisation. The rescue is temperature dependent (greater rescue at 25oC compared to 18oC). The ellipsoid body defects are not rescued.

    Scer\GAL4dpp.blk1 mediated expression of dacScer\UAS.cSa rescues eye development (fully rescues the morphogenetic furrow initiation defect) but the ommatidial array is disorganised.

    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (13)